Shubhangi Bichewar, Sujit Pillai, Rampal Singh Mandloi, Nikhlesh Birla, Sanket Jain
Shubhangi Bichewar*, Dr. Sujit Pillai, Rampal Singh Mandloi, Nikhlesh Birla, Sanket Jain
GRY Institute of Pharmacy, Borawan (Distt. Khargone) 451228 MP.
Volume - 13,
Issue - 12,
Year - 2020
Chronotherapeutic delivery system is required to be formulated to suit drug release conditions in various diseases like cardiovascular diseases, asthma etc. Asthma is disease of lung airways (bronchi) characterized by hyper active responsiveness to a variety of stimuli. Nocturnal asthma is condition where an exacerbation of the asthma is observed during the night times, such that worsening the functioning of the lung with increased airway response. Usually, asthma attacks are more predominant in early mornings so it is annoying for a patient to take medicine at late night, hence in this condition there is a demand for pulsatile drug delivery system which release the drug at required time at proper site with efficient therapeutic action. The main advantage of releasing the drug in required time in required quantity with satisfactory lag time. In the present study the doxofylline tablet was prepared by direct compression method and tablets were coated by dip coating method by using Sodium Starch Glycolate, Microcrystalline cellulose, Eudragit S100, Ethanol, Isopropyl alcohol, Dibutylpthalate. The tablets prepared were evaluated for various parameters like density parameters, thickness, hardness, friability, disintegration time, dissolution time. All parameters were found to be within limits. It was concluded that Formulation F6 was the ideal formulation with lag time of 6 hrs followed by burst release of drug.
Cite this article:
Shubhangi Bichewar, Sujit Pillai, Rampal Singh Mandloi, Nikhlesh Birla, Sanket Jain. Formulation and Evaluation of Chronomodulated drug delivery system of Doxofylline for treatment of Nocturnal Asthma. Research J. Pharm. and Tech. 2020; 13(12):6170-6175. doi: 10.5958/0974-360X.2020.01076.8
1. Gokhle AB, Saraf MN. Recent Development in asthama therapy. Indian Drugs. 2002; 39(3): pg no. 121
2. Moore R.Y. Circadian rhythms: basic neurobiology and clinical applications. Ann. Rev. Med. 1997; 48: 253-256.
3. Moore R.Y. Entertainment pathways and the functional organization of the circadian system. Brain Res.1996;111: 103-119.
4. Montplaisir J., Walsh J., J.L. Malo. Nocturnal asthma: features of attacks, sleep and breathing patterns. Am. Rev. Respir. Dis. 1982; 125: 18-22.
5. Pappenheimber J.R., Koski G, Fencyl V., Karnovsky M.L., and Krueger J.M. Extractions of sleep-promoting factors from cerebrospinal fluid and from brains of sleep-deprived animals. J. Neurophysiol. 1975; 38: 1299-1311.
6. Richard J. Martin and Susan Banks-Schlegeld. Chronobiology of Asthma. Am. J. Respir. Crit. Care Med., 1998; 158(3): 1002-1007.
7. Hetzel MR, Clark TJ. Comparison of normal and asthmatic circadian rhythms in peak expiratory flow rate. Thorax. 1980; 35: 1002-1007.
8. Kraft M, Pak J, Martin RJ. Serum cortisol in asthma: marker of nocturnal worsening of symptoms and lung function? Chronobiollnt.1980;15: 85-92.
9. Ballard RD, Saathoff MC, Patel DK. et al. Effect of sleep on nocturnal bronchoconstriction and ventilator patterns in asthmatics. J ApplPhysiol 67(1), 1989, 243-249.
10. Philip E Silkoff. and Richard J Martin. Pathophysiology of nocturnal asthma. Annals Of Allergy, Asthma and Immunology. 1998;81: 378-387.
11. Anamika Singh et al. Pulsatile Drug Delivery System: an Approach of Medication according to Circadian Rhythm. Journal Of Applied Pharmaceutical Science. 2012; 02 (03): 166-176.
12. G. Sree Lakshmi, Gowthamy Priya, kumar Sravan et al. Formulation and evaluation of chrono modulated pulsatile drug delivery system of doxofylline. Int. J. of Pharmacy and Analytical Research. 2017; Vol-6(3): 526-531.
13. Arora Shweta, Ali. J, Ahuja Alka, Baboota Sanjula and Qureshi J. Pulsatile Drug Delivery Systems: An Approach for Pulsatile Drug Delivery Systems: An Approach for Controlled Drug Delivery. Indian Journal of Pharmaceutical Sciences. 2006;68(3): 295-300
14. Patil Ajit, Payghan Santosh, disouza John. Formulation and evaluation of Enteric Coated tablets of Azithromycin dehydrate. International Journal of Chem Tech Research. 2011; 3(3): 1479-1484.
15. Mehta Rohit, Chawla Anuj, Sharma Pooja, Pawar Pravin. Formulation and evaluation of Eudragit S-100 coated naproxen matrix tablets for colon – targeted drug delivery system. J. Adv. Pharm. Tech. Res. 2019;4(1): 31-41.
16. Lachman L, Liberman H A, Kanig J L, the Theory And Practice of Industrial Pharmacy, Varghese Publishing House, Mumbai, 3rd edition, 1990; 296-302.
17. Indian Pharmacopoeia, published by controller of publication and Ministry of Health, Volume II, 2007, 2010; 459-463.
18. United States Pharmacopoeia, The National Formulary, 20th Edition, United State Pharmacopoeial Convention INC, Washington, 2002; 711, 2011.