Author(s): Baida Rihan Ali

Email(s): bydaali@yahoo.com

DOI: 10.5958/0974-360X.2020.01056.2   

Address: Baida Rihan Ali
Department of Pathological Analysis, College of Science, University of Thi-Qar, Iraq.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
The current study was intended to explore some biochemical and hormonal modifications in females with Polycystic Ovary Syndrome in Nasiriyah City. A (90) blood samples were collected from adult females and split into three groups (n = 30), the first group (control), the second group (hypertestosteronemia) and the third group (diabetic).” “The results of table (1) showed a significant increase (P = 0. 0 5) of in testosterone, L H, prolactin, B. S, T G and T S H in the third group compared to the second and control groups. While the results showed a substantial rise in the second group of testosterone, L H, prolactin, B. S, T G and T S H compared to the control group. There is also non-significant F S H (Pentry 0.05) in three groups. While the results showed a substantial reduction relative to the control group in H D L, T 3 and T 4 in the first and second groups (P = 0. 0 5).” “The results of table (2) showed a significant increase (P = 0. 0 5) of in Testosterone, L H, prolactin, B. S, T G and T S H in the third group compared to the second and control groups. While the results indicated a significant increase in the second group of Testosterone, L H, Prolactin, B. S, T G and TSH compared to the control group. So, there is non-significant F S H (P =0 .05) in three groups. While the findings showed a significant decrease (P =0.05) in H D L, T 3 and T 4 in the third and second groups compared to the control group, the findings showed a substantial decline in HDL, T3 and T4 in the third group compared to the second group.”


Cite this article:
Baida Rihan Ali. Effecting of Male Hormone (Hypertestosteronemia) and Diabetes on Some Biochemical and Hormonal Parameters in Women with Polycystic Ovary Syndrome in Nasiriyah city. Research J. Pharm. and Tech. 2020; 13(12):6061-6065. doi: 10.5958/0974-360X.2020.01056.2


REFERENCES:
1.    Atis G, Dalkilinc A, Altuntas Y, Atis A, Caskurlu T, Ergenekon E. Sexual dysfunction in women with clinical hypothyroidism and subclinical hypothyroidism. J Sex Med; 2010,7:2583–90. [PubMed] [Google Scholar].
2.    Baptiste CG, Battista M-C, Trottier A, Baillargeon J-P. Insulin and hyperandrogenism in women with polycystic ovary syndrome. J Steroid Biochem Mol Biol; 2010,122: 42-52.
3.    Beaker, K. L. Principle and practice of endocrinology and metabolism, 3th edition, Lippincott Williams and Wilkins, Philadelphia;2001, 918-1015.
4.    Carmina E, Guastella E, Longo RA. Advances in the diagnosis and treatment of PCOS. Curr Pharmaceut Des;2016, 22: 5508-5514.
5.    Goldzieher, J.W. Polycystic ovarian disease. Fertil Steril;1989,35: 371-394.
6.    Eagleson Ch. A, Gingrich MB, Pastor CL, et al. Polycystic ovarian syndrome: Evidence that flutamide restors sensitivity of the Gonadotropin – Releasing Hormone pulse Generator to inhibition by estradiol and progesterone. J Clin Endocrinol Metab;2000, 85(11): 4047-4052.
7.    Eibl NL, Koop HP, Nowak HR, et al. Hypomagnesemia and type II diabetes. Diabetes Car;1995,18:188-192.
8.    Hapon MB, Gamarra-Luques C, Jahn GA. Short term hypothyroidism affects ovarian function in the cycling rat. Reprod Biol Endocrinol;2010,8:14. [PMC free article] [PubMed] [Google Scholar].
9.    Hage M, Zantout MSM, Azar ST. Tyroid disorders and diabetes mellitus. J Thyroid Res ;2011,439463. [PMC free article] [PubMed] [Google Scholar].
10.    Ibrahim. W, Abdel Salam. KEA. Levels of FSH, LH, SHBG, Total Testosterone, and LH/FSH ratio in Sudanese patients with polycystic ovary syndrome in relation to body mass index. International Journal of Current Research;2015, 7(1):11919-22.
11.    Imani B, Eijkemans MJ, de-Jong FH, et al. Free androgen index and leptin are the most prominent endocrine Predictors of ovarian response during clomphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility. J Clin Endocrinol Metab;2000, 85 (2) :676-682.
12.    J. Feely and T. E. Isles. “Screening for thyroid dysfunction in diabetics,” British Medical Journal;1979, vol. 1, no. 6179, p. 1678.
13.    J. Rezzonico, M. Rezzonico, E. Pusiol, F. Pitoia, and H. Niepomniszcze, “Introducing the thyroid gland as another victim of the insulin resistance syndrome,” Thyroid; 2008, vol. 18, no. 4, pp. 461–464.
14.    Kahn SM, Hryb DJ, Nakhla A.M. et al. Sex hormone binding globulin (SHBG) is Synthesized in target cells. Clinc Endocrinol;2003, 175(1) :113-120.
15.    Keramat, A. Masoomi, S.Z. Mousavi, S.A. Poorolajal, J. Shobeiri, F. et al. Quality of life and its related factors in infertile couples. J Res Health Sci;2014, 14: 57-63.
16.    Mirella Hage, Mira S. Zantout, and Sami T. Azar. Thyroid Disorders and Diabetes Mellitus. Journal of Thyroid Research, Article ID 439463,2011; 7 pages.
17.    Monga M, Alexandrescu B, Katz SE, Stein M, Ganiats T. Impact of infertility on quality of life, marital adjustment and sexual function. Urology;2004, 63: 126-130.
18.    Nestler, J.E. Jakubowicz, D.J. Falcon, A.et al. Insulin stimulate testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositologly can mediators as the signal transduction system. J Clin Endocrinol Metab;1998, 83: 2001-2005.
19.    Pasquali Al-Rarama, Gambineri, A. Biscotti, D. et al. Effect of long term treatment with Metformin added to hypocaloric diet on body composition, fat, distribution and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome. J Clin Endocrinol Metab;2000, 85(8):2767-2774.
20.    Porterfield, S.P. The thyroid gland. In Endocrine Physiology. St. Louis, Mo., Mosby;1997, p.57 –81. (Google Scholar).
21.    Roe AH, Dokras A. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Reviews in Obstetrics and Gynecology;2011, 4(2):45-51.
22.    R. S. Gray; W. J. Irvine, and B. F. Clarke. “Screening for thyroid dysfunction in diabetics,” British medical journal;1979, vol. 2, no. 6202, p. 1439.
23.    Sanjay. S, Bharti. S, Rajeev. P, Kumar. S, Sureshrao. A, Puspalata. A, and Pankaj, A. Effect of hypothyroidism on female reproductive hormones. Indian J Endocrinol Metab. Jan-Feb;2016, 20(1): 108–113.
24.    S. Ayturk, A. Gursoy, A. Kut, C. Anil, A. Nar, and N. B. Tutuncu, “Metabolic syndrome and its components are associated with increased thyroid volume and nodule prevalence in a mild-to-moderate iodine-deficient area,” European Journal of Endocrinology;2009, vol. 161, no. 4, pp. 599–605.
25.    Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN, Pal SK. Thyroid disorders in polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectional study from Eastern India. Indian Journal of Endocrinology and Metabolism;2013, 17(2):304-9.
26.    Teede H, Deeks A, Moran L. Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan. BMC Med;2010, 8: 41.
27.    V. Coiro, R. Volpi, C. Marchesi et al. “Influence of residual C-peptide secretion on nocturnal serum TSH peak in well controlled diabetic patients,” Clinical Endocrinology;1997, vol. 47, no. 3, pp. 305–310.
28.    Willet K, Baron S, Marceau G et al. Emerging roles for LXRs and LRH-1 in female reproduction. Mol. Cell. Endocrinol;1996, doi:10.1016/j.mce.2012.06.009.
29.    Yen, S.S. the polycystic ovary syndrome. Clin Endocrinol; 1980,12: 177-208.
30.    Yildis, B.O, Yarali, H, Oguz, H. Glucose intolerance, Insulin resistance, and Hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome. J Clin Endocrinol Metab;2003,88(5):2031-2036.
31.    Yildiz BO, Bolour S, Woods K, Moore A, Azziz R. Visually scoring hirsutism. Human Reprod Update 2010; 16: 51-64.

Recomonded Articles:

Author(s): Hasan Qader Sofihussein, Abdulqader Azeez Al-Naqshabandi, Hawri Fatih Sami, Mudhafar Mohamed M. Saeed

DOI: 10.5958/0974-360X.2020.00728.3         Access: Closed Access Read More

Author(s): Dania E. Ibrahim, Wisam Kadhum H. Alhashemi, Sajid Ibrahim Alhussaini

DOI: 10.5958/0974-360X.2020.00064.5         Access: Closed Access Read More

Author(s): Kalmath K. V., Swamy H. K. S., Inamdar S. S.

DOI:         Access: Open Access Read More

Author(s): Doaa Mahdi Omran, Saad Merza Alaraji, Ali Hussein Albayati, Wathiq Essam

DOI: 10.5958/0974-360X.2018.00052.5         Access: Open Access Read More

Author(s): Areej Atiyah Hussein, Basim Mohammed Khashman

DOI: 10.5958/0974-360X.2019.00766.2         Access: Open Access Read More

Author(s): Suwarna Dangore Khasbage, Neha Agrawal, Rahul Bhowate

DOI: 10.5958/0974-360X.2020.00737.4         Access: Closed Access Read More

Author(s): Muhammed A. H. Aldabagh, Sahar S. Karieb, Ali N. Yassen, Saddam H. Jaber, Mohammed S. Abbas, Ali M. Jawad

DOI: 10.5958/0974-360X.2019.00319.6         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags