Author(s): Satuluri Vineela, Santh Rani Thakur

Email(s): vineela.cology@gmail.com

DOI: 10.5958/0974-360X.2020.01048.3   

Address: Satuluri Vineela1*, Santh Rani Thakur2
1Assistant Professor, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India- 522019.
2Division of Pharmacology, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India- 517 502.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
Aim and Objective: In this study, we examined the possible protective effect of sinapic acid (SA) on acrylamide (ACR) induced neurotoxicity in both in-vitro and in-vivo models. Methods: U87MG cells were exposed to different concentrations of sinapic acid. After 24 hours, ACR was added to the cells and cell viability was measured through MTT assay. In in-vivo study, acrylamide administration (50 mg/kg bw, i.p. 3 times/ week) for 4 weeks produced typical symptoms of neuropathy in rats. Rats were subjected to behavioral tests each week. Finally, after assessing behavior rats were sacrificed under light ether anesthesia and the excised SN was processed for biochemical analysis. Results: SA (30 mg/kg, for 4 weeks) significantly improved in neurological score and responses in a battery of behavioral tests. Sinapic acid markedly attenuated ACR-induced markers of oxidative stress viz., malondialdehyde (MDA) and improved the reduced glutathione (GSH) and superoxide dismutase (SOD) in sciatic nerve (SN). ACR reduced the cell viability in a concentration-dependent manner. Sinapic acid reversed ACR induced cytotoxicity. Conclusion: Our ?ndings suggest the propensity of SA to attenuate ACR-induced neuropathy by attenuating oxidative stress.


Cite this article:
Satuluri Vineela, Santh Rani Thakur. Sinapic acid ameliorates Acrylamide induced Neurotoxicity through inhibition of oxidative stress in rats. Research J. Pharm. and Tech. 2020; 13(12):6009-6016. doi: 10.5958/0974-360X.2020.01048.3


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