MM Riyaniarti Estri W, Nashi Widodo, Edi Widjajanto, Yoga Dwi Jatmiko, Muhaimin Rifa’i
MM Riyaniarti Estri W1,2, Nashi Widodo1, Edi Widjajanto3, Yoga Dwi Jatmiko1, Muhaimin Rifa’i1*
1Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, Indonesia.
2Department of Biology, Faculty of Sciences, Technology and Analitycal, Institut Ilmu Kesehatan Bhakti Wiyata Kediri, Indonesia.
3Departement of Medicine, Faculity of Medicine, Brawijaya University, Malang Indonesia.
Volume - 13,
Issue - 12,
Year - 2020
Oxidative stress can occur due to an imbalance between increased free radical production and a decrease in antioxidant capacity. Reactive Oxygen Species (ROS) excess will react with biological macromolecules either proteins or DNA and potentially damage hepatocytes. Nrf- 2 activations can trigger the expression of anti-oxidative enzymes, such as HO-1 and SOD-2, which have important role in preventing inflammation. The purpose of this study was to look at the expressions of Nrf-2, HO-1, SOD-2, and histopathological features of Balb/C mice injected with Salmonella typhi after fermented extract administration of red Moringa oleifera. Data were analyzed by SPSS 22.0 ANOVA (p < 0.05) and followed by Duncan’s Multiple Range Test. The results showed that fermented extract of red Moringa oleifera leaves could act as an immunomodulatory agent characterized by increased expressions of Nrf-2, HO-1, and SOD-2. Here, we also showed the histology improvement in Salmonella- injected mice after received fermented extract of red Moringa oleifera.
Cite this article:
MM Riyaniarti Estri W, Nashi Widodo, Edi Widjajanto, Yoga Dwi Jatmiko, Muhaimin Rifa’i. Red Moringa oleifera leaf fermentation extract protecting Hepatotoxicity in Balb/C mice injected with Salmonella typhi through Nrf-2, HO-1, and SOD-2 signaling pathways. Research J. Pharm. and Tech. 2020; 13(12):5947-5952. doi: 10.5958/0974-360X.2020.01038.0
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