Author(s): Mohammad Akthar Sulthana, Mangulal Kethavath, Fazil Ahmad, Abeer Mohammed Al-Subaie

Email(s): aktharsulthana95@gmail.com

DOI: 10.5958/0974-360X.2020.01031.8   

Address: Mohammad Akthar Sulthana1, Dr. Mangulal Kethavath2, Dr. Fazil Ahmad3, Dr. Abeer Mohammed Al-Subaie4
1Department of Pharmaceutics, SLC College of Pharmacy. Address, Piglipur (V) Near Ramoji Film City, Hayathnagar (Dist)- 501512, Telangana, India.
2Assistant Professor, Department of Pharmaceutics, SLC College of Pharmacy. Address, Piglipur (V) Near Ramoji Film City, Hayathnagar (Dist)- 501512, Telangana, India.
3Assistant Professor, Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, P.O. Box 4030, Jubail, Saudi Arabia.
4Assistant Professor of Haematology, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam, Saudi Arabia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
The aim of the present study is to formulate Sustained release tablets of elvitegravir solid dispersions. The enhancement of oral bioavailability of poorly water soluble drugs like Elvitegravir could be improved by enhancing aqueous solubility. Among numerous ways of enhancing drug dissolution, solid dispersions and inclusion complexation are promising techniques to enhance the dissolution of poorly water soluble drugs. The calibration curve of Elvitegravir was obtained in the range of 2-10µg at the wavelength of 313 nm. It has shown good linearity with a regression coefficient of 0.999 (r2 value). This result exhibit a direct relationship between concentration of polymers and drug release. Among the various formulations tablets of batch E2 prepared with 40mg Guar gum showed complete release of drug within 24 hrs.


Cite this article:
Mohammad Akthar Sulthana, Mangulal Kethavath, Fazil Ahmad, Abeer Mohammed Al-Subaie. Formulation Development and invitro evaluation of Elvitegravir sustained release using solid Dispersions. Research J. Pharm. and Tech. 2020; 13(12):5909-5913. doi: 10.5958/0974-360X.2020.01031.8


REFERENCES:
1.    Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm. 2000;50:47-60.
2.    Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J. Pharm Sci. 1971;60(9):1281-1302.
3.    Corrigan OI, Stanley T. Mechanisms of dissolution of fast release solid dispersions. Drug Dev Ind Pharm. 1985;11:697-724.
4.    Vasconcelos TF, Sarmento B and Costa P. Solid dispersions as strategies to improve the oral bioavailability of poorly water soluble drugs. Drug Discovery Today.2007;12:23-24.
5.    Sheu MT, Yeh CM, Sokoloski TD. Characterization and dissolution of fenofibrate solid dispersion systems. Int J Pharm. 1994;103:137-146.
6.    Duncan QMC. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int J Pharm. 2002; 231:131-144.
7.    Kuchekar BS, Bhise SB, Armugam V. Design of fast dissolving tablets. Indian J. Pharm Edu. 2001;35(4):50-53.
8.    Mosher G. Complexation and cyclodextrin In: Swarbrick J, Boylan JC, editors. Encyclopaedia of Pharmaceutical Technology.: Marcel Dekker Inc.; 2002;531-558.
9.    Martin A. Complexation and protein binding. Physical pharmacy, 4th Edition, 1993; Waverly International, 428 St. Preston street, Maryland, USA, 258-260.
10.    Mishra PR, Mishra M, Namdeo A, Jain NK. Review article: Pharmaceutical potential of cyclodextrin. Indian J Pharm Sci. 1999;61:193-198.
11.    Rajewski RA, Stella VJ. Pharmaceutical applications of cyclodextrin. II. In vivo drug delivery. J Pharm Sci. 1996; 85: 1142-1169.
12.    Uekama K, Fujinaga T, Hirayama F, Otagiri M, Yamasaki M, Seo H . Improvement of the oral bioavailability of digitalis glycosides by cyclodextrin complexation. J. Pharm Sci. 1983; 72: 1338-1341.
13.    Sastry S, Nyshdham J, Fix J. Recent technological advances in oral drug delivery: A review. AAPS Pharm Sci Tech. 2000; 13:138-44.
14.    Reddy LH, Ghosh B, Rajneesh. Fast dissolving drug delivery systems: A review. Indian J. Pharm Sci. 2002;7:331-36.
15.    Sameer Singh et al (2(9): Sep., 2011)., Solid dispersions improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): M. Sunitha Reddy, Ch. Surekha, G. Anusha, S. Mallikarjun Reddy, K. Manasa, G. Sowmya

DOI: Not Available         Access: Open Access Read More

Author(s): Barokar A.A., Wagh R.D., Baviskar D.T., Shaikh T.J.

DOI: Not Available         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Saumya Mishra, Dulal Krishna Tripathi

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Kuldeep Malodia, Sunil Kumar, Pankaj Rakha, SK Singh, DN Mishra

DOI: Not Available         Access: Open Access Read More

Author(s): Samiksha Warke, Prashant Warke, M.K. Kale, Vipin Saini

DOI: Not Available         Access: Open Access Read More

Author(s): Mythili. L, GNK. Ganesh, C. Monisha, Kayalvizhi. R

DOI: 10.5958/0974-360X.2019.00426.8         Access: Open Access Read More

Author(s): Gupta Khemchand, Singhvi I., Ashawat M.S., Gupta Santosh Kumar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags