Author(s): Y. H. Momin, V. C. Yeligar

Email(s): ,

DOI: 10.5958/0974-360X.2020.01027.6   

Address: Y. H. Momin1*, V. C. Yeligar2
1Department of Pharmaceutical Chemistry, Annasaheb Dange College of B. Pharmacy, Ashta 416301, India.
2Department of Pharmaceutical Chemistry, Oxford College of Pharmacy, Bangalore, 560078, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020

Background: Gas chromatography-Mass spectroscopy is comprehensive techniques for identification of bioactive components present in medicinal plants. Objective: Objective of present study was analysis of chloroform extract of stem part of Coccinia grandis Voigt plant belonging to Cucurbitaceae by Gas chromatography- Mass spectroscopy (GC-MS). Material and Methods: After Successive extraction with petroleum ether, chloroform and ethyl acetate for selected plant, further Chloroform stem extract was analyzed for different bioactive compounds by GC-MS method. Result and Discussion: The GC –MS data of chloroform extract of stem part of Coccinia grandis Voigt plant showed 24 bioactive phytoconstituents such as Spiro [4.5] dec-6-en-8-one, Hexadecanoic acid methyl ester, Cyclononasiloxane octadecamethyl, 9-Heptadecanone, 2, 4-Di-tertbutylphenol, 1, 7-dimethyl-4-(1-methylethyl), 7, 9-Di-tert-butyl-1-oxaspiro (4, 5) deca-6, 9-diene-2, 8 dione. Hexadecanoic acid and 2, 4-Di-tert-butylphenol are an antioxidant agents and Spiro [4.5] dec-6-en-8-one 1, 7- dimethyl-4-(1-methylethyl), 9 heptadecanone, Hexadecanoic acid methyl ester shown antimicrobial property. Conclusion: Present study concluded that development of potential bioactive compounds identified from GC MS analysis could serve better approach for treatment of various diseases such as microbial infection, fungal infection, inflammation, diabetes mellitus.

Cite this article:
Y. H. Momin, V. C. Yeligar. Gas Chromatography-Mass Spectrometry Analysis of Chloroform Extract of Coccinia grandis Voigt. Research J. Pharm. and Tech. 2020; 13(12):5889-5892. doi: 10.5958/0974-360X.2020.01027.6

1.    Dulf FV, Vodnar DC, Dulf EH, Pintea A. Phenolic compounds, flavonoids, lipids and antioxidant potential of apricot (Prunus armeniaca L.) pomace fermented by two filamentous fungal strains in solid state system. Chem. Cent. 2017; 11: 92.
2.    Tamilselvan N, Thirumalai T, Elumalai E, Balaji R, and David E. Pharmacognosy of Coccinia grandis: a review. Asian. Pac. J. Trop. Biomed 2011; S299-S302.
3.    Packirisamy M, Ayyakkanuu P, and Sivaprakasam M. Antioxidant, antiglycation and insulinotrophic properties of Coccinia grandis (L.) in vitro: Possible role in prevention of diabetic complications J. Trad and Compl. Med., 2017, 7, 54-64.
4.    Krishnamoorthy K and Subramanian P. Phytochemical Profiling of Leaf, Stem, and Tuber Parts of Solena amplexicaulis (Lam.) Gandhi Using GC-MS. Int. Sch. Res. Notices 2014; 1-13.
5.    Robertson DG. Metabonomics in Toxicology: A Review. Toxicological Sciences 2005; 85(2): 809–822.
6.    Kell DB, Brown M, Davey HM, Dunn WB, Spasic I, and Oliver SG. Metabolic foot printing and systems biology: the medium is the message. Nature Reviews Microbiology 2005; 3(7): 557–565.
7.    Pandian RS, Noora AT. GC-MS analysis of phytochemical compounds present in the leaves of Citrus medica. L. Research J Pharmacy Technology 2019; 12 (4):1823-1826.
8.    Prabha N and Bushra JR. Gas Chromatography Mass Spectrometry analysis of Andrographis paniculata. Asian J Research Chemistry 2019; 12 (1): 01-06.
9.    Kokate CK: Pharmacognosy. Nirali Prakashan.2001; Sixteenth Edition.
10.    Sharma H K, and Alagarsamy V. In-Vitro antimicrobial activity of various extracts of Dyschoriste littoralis Nees Int. J. Phytopharmacol 2013; 4(3): 212-216.
11.    Harborne JB: Phytochemical methods. A guide to modern technique of plant analysis. Chapman and Hall co, New York.1998; Third Edition 1–302.
12.    Eswaraiah G, Peele KA, Krupanidhi S, Indira M, Bharath Kumar R, and Venkateswarulu TC. GC–MS analysis for compound identification in leaf extract of Lumnitzera racemosa and evaluation of its in vitro anticancer effect against MCF7 and HeLa cell lines. J King Saud.Uni. In Press.
13.    Anandan A, Eswaran R, Doss A, Sangeetha G, and Anand SP. Investigation for bioactive compounds of Aerva lanata (L.) Juss. ex Schultes. Asian J Research Chemistry 2012; 5 (4): 469-471.
14.    Hussein JH, Imad HH, and Mohammed YH. Using Gas Chromatography-Mass Spectrometry (GC-MS) technique for analysis of bioactive compounds of methanolic leaves extract of Lepidium sativum. Research J Pharmacy Technology 2017; 10 (11): 3981-3989.
15.    Patel J, Reddy V, Kumar GS, Satyasai D, and Bajari B. Gas chromatography and mass spectroscopy analysis of bioactive components on the leaf extract of Terminalia coriacea: A potential folklore medicinal plant. Int J Green Pharm 2017; 11(1): 140-3.
16.    Kontham KV, Leena D, Ganesan S, Sulochana P, Pandey A, Kesavan MN. 2, 4-Di-tert-butyl phenol as the antifungal, antioxidant bioactive purified from a newly isolated Lactococcus sp. Int. J. Food Microbiology 2015; 211: 44-50.
17.    Krishnamoorthy K and Subramaniam P. Phytochemical profiling of leaf, stem, and tuber parts of Solena amplexicaulis (Lam.) Gandhi Using GC-MS. Int Sch Res Notices 2014; 1-13.

Recomonded Articles:

Author(s): Koushika Das, Pranit Krishna, Avipsha Sarkar, Shanmuga Sundari Ilangovan, Shampa Sen

DOI: 10.5958/0974-360X.2017.00267.0         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Rekha Rajendran, R Hemachander, T Ezhilarasan, C Keerthana, DL Saroja, KV Saichand, Mohamed Gasim Abdullah

DOI: Not Available         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Dhanalekshmi UnniKrishnan Nair, MP Saraswathy, Narra Kishore, Neelakanta Reddy Pully

DOI: Not Available         Access: Open Access Read More

Author(s): A. Julius, Ramachandran Vedasendiyar, Archana Devakannan, Sujatha Rajaraman, Balamurugan Rangasamy, V. Saravanan

DOI: 10.5958/0974-360X.2017.00062.2         Access: Open Access Read More

Author(s): T. Arunkumar, Ann Feba Ebby, G. Narendrakumar

DOI: 10.5958/0974-360X.2017.00441.3         Access: Open Access Read More

Author(s): Shrivastava Alankar, Jain R., Agrawal R.K., Ahirwar D.

DOI:         Access: Open Access Read More

Author(s): Josephin Nerling Rashida G., T. Venkatarathnakumar, R. Gowri, Ajithadhas Aruna

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): Mahanthesh M.C., Girendra Gautam, Jalalpure S.S.

DOI: 10.5958/0974-360X.2017.00250.5         Access: Open Access Read More

Author(s): Rupesh Pandey, Priyanka Upadhayay, Shiv Shankar Shukla

DOI:         Access: Open Access Read More

Author(s): Anket Sharma, Vinod Kumar, Parminder Kaur, Ashwani Kumar Thukral, Renu Bhardwaj

DOI: 10.5958/0974-360X.2015.00299.1         Access: Open Access Read More

Author(s): Md Kamal Hossain, Kamrun Nahar, Parisa Shokryazdan, Norhani Abdullah, Kaiser Hamid, Mohammed Faseleh Jahromi

DOI: 10.5958/0974-360X.2017.00530.3         Access: Open Access Read More

Author(s): Manisha N. Trivedi, Archana Khemani, Urmila D. Vachhani, Charmi P. Shah, D.D. Santani

DOI: Not Available         Access: Open Access Read More

Author(s): Aravind R., Bindu A.R., Bindu K., Alexeyena V.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles