Author(s): Y.E. Matiichuk, M.I. Sulyma, T.I. Chaban, V.V. Ogurtsov, V. S. Matiychuk

Email(s): chabantaras@ukr.net

DOI: 10.5958/0974-360X.2020.01017.3   

Address: Y.E. Matiichuk1, M.I. Sulyma1, T.I. Chaban1*, V.V. Ogurtsov1, V. S. Matiychuk2
1Department of General, Bioinorganic, Physical and Colloidal Chemistry, Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv, 79010, Ukraine.
2Department of Organic Chemistry, Ivan Franko National University of Lviv, 6 Kyryla and Mefodia, Lviv, 79005, Ukraine.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
By the reaction of furan-2-carboxylic acids with diazonium salts 1a-e the arylfuran-2-carboxylic acids 3a-e were synthesized. Acids 3a-e were transformed into appropriated acylchlorides 4a-e and were used for preparation of N-(R1-phenyl)-5-(R-phenyl)-2-furamides 6a-k. The structures of target compounds 6a-k were confirmed by using 1H NMR spectroscopy and elemental analysis. The compounds 6d-f with high antimicrobial activity against C. Neoformans ATCC 208821 were identified. It also have been found that compound 6i to be high active and against PC-3 Prostate Cancer cell lines (GP = 34.42) and 6f SR Leukemia cell lines (GP = 59.81).


Cite this article:
Y.E. Matiichuk, M.I. Sulyma, T.I. Chaban, V.V. Ogurtsov, V. S. Matiychuk. Synthesis and Biological evolution N-(R1-phenyl)-5-(R-phenyl)-2-furamides. Research J. Pharm. and Tech. 2020; 13(12):5837-5843. doi: 10.5958/0974-360X.2020.01017.3


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