Author(s): Kholida Yunusova, Sevara Ravshanova

Email(s): sravshanova@gmail.com

DOI: 10.5958/0974-360X.2020.01001.X   

Address: Kholida Yunusova, Sevara Ravshanova*
Department of Industrial Technology of Medicines, Tashkent Pharmaceutical Institute, Aybek 45, 100015, Tashkent, Uzbekistan.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
This study aimed to develop a method for the quantitative determination of active medicinal substances that are part of a combined analgesic tablet under the code name "Analfenon". We previously developed technology obtaining combined ternary tablets with a potential analgesic effect which contains metamizole sodium, drotoverin hydrochloride, diphenhydramine hydrochloride. The amount of metamizole sodium, drotaverine hydrochloride, diphenhydramine hydrochloride was analyzed by methods spectrophotometry and titrimetry. Using the developed technique, the content of metamizole sodium, drotoverin hydrochloride, diphenhydramine hydrochloride in 5 samples was determined. The results of the quantitative analysis were evaluated using the metrological analysis. The results showed that the active drugs contained in the tablet are within the limits specified in the normative technical document. The proposed methods for the analysis of analgesic combined tablets provide reliable and well reproducible results. The developed methods formed the basis of regulatory documentation for a new analgesic drug - Analfenon tablets.


Cite this article:
Kholida Yunusova, Sevara Ravshanova. Quantitative Analysis of Combined Analgetic Tablets. Research J. Pharm. and Tech. 2020; 13(12):5749-5753. doi: 10.5958/0974-360X.2020.01001.X


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