Author(s): Supriya Shinde, Vishal Yadav, Prakash Jadhav, Apoorva Jadhav

Email(s): supi.pawar89@gmail.com

DOI: 10.5958/0974-360X.2020.00997.X   

Address: Supriya Shinde1*, Vishal Yadav2, Prakash Jadhav2, Apoorva Jadhav2
1Sawkar Pharmacy College, Jaitapur- 415004, Satara, Maharashtra, India.
2Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur- 415004, Satara, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
The objective of this study was to develop an oral microemulsion formulation of the antihypertensive drug to enhance its bioavailability. The microemulsions were formulated by using Tween 20 as a surfactant, PEG 400 as co-surfactant and peppermint oil. Excipient ratio i.e. surfactant: co-surfactant ratio was kept 2:1, 3:1, 5:1. Microemulsions were characterized by particle size analysis and viscosity, after applying an experimental design. The formulation containing less surfactant: co-surfactant and less oil possessed less particle size and less viscosity. On the basis of appropriate parameters, formulation F7 was selected as an optimized batch optimized batch F7 was analyze for in vitro drug release study, zeta potential, physical stability. Batch F7 shows negative zeta potential which assures a good physical stability of the formulation. Dissolution study was carried out in 0.1 N HCl pH 1.2, and phosphate buffer pH 7.4% Drug release at 24 h for microemulsion formulation in the 0.1 N HCl pH 1.2, and phosphate buffer pH 7.4 was found to be 91.32% and 92.44% respectively, i.e. almost 90% release at all pH conditions within 24 h. So it was concluded that pure drug require maximum time for compete drug release than Microemulsion. Physical stability study of optimized batch F7 was carried out for 1 month. It was concluded that no change in formulation was observed after 1 month and observed for the change in Physical appearance, pH, average Particle size, and Zeta potential. It was observed that there was no change in the physical appearance Furthermore, there was no significant change observed.


Cite this article:
Supriya Shinde, Vishal Yadav, Prakash Jadhav, Apoorva Jadhav. Formulation and Evaluation of Microemulsion containing Anti-Hypertensive Drug. Research J. Pharm. and Tech. 2020; 13(12):5726-5732. doi: 10.5958/0974-360X.2020.00997.X


REFERENCES:
1.    Muzaffar F. et al. presented Review on Microemulsion as Futuristic Drug Delivery International Journal of Pharmacy and Pharmaceutical Sciences, 2013; 5 (3): 39-53.
2.    Badawi A A et al. presented a research work on preparation and Evaluation of Microemulsion Systems Containing Salicylic Acid AAPS Pharm Sci Tech, 2009; 10(4).
3.    Moghimipour E et al. Salimi A, Eftekhari S. Design and characterization of microemulsion systems for naproxen. Advanced Pharmaceutical Bulletin, 2013, 3(1), 63-71.
4.    Ding Qu et al. presented preparation and in vivo evaluation, Triterpene-loaded microemulsion using Coix lacryma-jobi seed extract as oil phase for enhanced antitumor efficacy, International Journal of Nanomedicine,2013;20:109-119
5.    Patel D et al. Sawant KK. Presented Self micro-emulsifying drug delivery system: formulation development and biopharmaceutical evaluation of lipophilic drugs. Curr Drug Delivery. 2009; 6(4):419-24.
6.    Baek K M et al. presented preparation and evaluation of Self-microemulsifying drug-delivery system for improved oral bioavailability of pranlukast hemihydrates, International Journal of Nanomedicine 2013:8 167–176.
7.    Moghimipour E, et al. Salimi A, Leis F Preparation and Evaluation of Tretinoin Microemulsion Based on Pseudo-Ternary Phase Diagram Advanced Pharmaceutical Bulletin, 2012, 2(2), 141-147.
8.    Dhruti P. Mehta1*, et al. presented A Review on Microemulsion Based Gel: A Recent Approach for Topical Drug Delivery System Research J. Pharm. and Tech.8 (2): February 2015, 118-126.
9.    Chopade V, et al. Self-Emulsifying Drug Delivery System: A Review. International Journal of Chemistry and Pharmaceutical Sciences. 2 (1); 2013: 34-44.
10.    Madhav. S and Gupta. D et al. A review on microemulsion based system. International Journal of Pharmaceutical Sciences and Research 2011; 2 (8): 1888.
11.    Kumar. K. Senthil et al. Microemulsions as Carrier for Novel Drug Delivery: A Review. International Journal of Pharmaceutical Sciences Review and Research 2011; 10: 37-45.
12.    Jaiswal P, et al. Development of self-microemulsifying drug delivery system and solid-self-microemulsifying drug delivery system of telmisartan Int J Pharm Investig. 2014; 4(4): 195–206.
13.    Padia N, et al. Development and Characterization of Telmisartan Self-microemulsifying drug delivery system for Bioavailability Enhancement. Journal of Scientific and Innovative Research 2015; 4(3): 153-164.
14.    Sarkhejiya Naimish A et al. Emerging Trend of Microemulsion in Formulation and Research. International Bulletin of Drug Research. 2000; 1 (1): 54-83.

Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Leelavathi D Acharya, N R Rau, N Udupa, Surulivel Rajan M, Vijayanarayana K

DOI: 10.5958/0974-360X.2016.00162.1         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Mohd Yousuf Ali, Md Shamim Qureshi, Md Hamed, Byasabhusan Das and K Purushotham Rao

DOI: Not Available         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags