Author(s): Farah Hamad Farah

Email(s): f.hamad@ajman.ac.ae

DOI: 10.5958/0974-360X.2020.00995.6   

Address: Farah Hamad Farah
Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman P O Box 346, United Arab Emirates.
*Corresponding Author

Published In:   Volume - 13,      Issue - 12,     Year - 2020


ABSTRACT:
This study investigates the influence of wide range of concentrations of the model cationic, surface-active drug chlorpromazine hydrochloride (CPZ-HCl) partitioning into dimyrstoylphosphatidylcholine (DMPC) liposomes in phosphate buffer (pH 6.0) as a function of temperature, both below and above the phase transition temperature (Tc) of DMPC, pertinent to calculate various thermodynamic parameters using the Van’t Hoff equation. The partitioning of CPZ-HCl into DMPC liposomes was found to be concentration dependent at temperature both below and above the phase transition temperature (Tc). The temperature dependence of the equilibrium partition coefficient (K) over the temperature range 5o-40oC permitted the calculation of free energy (?G (W/L)), enthalpy (?H (W/L)) and entropy (?S (W/L)) of partitioning using the Van’t Hoff equation. ?G (W/L) values for all concentrations studied were negative indicating that the partitioning of CPZ-HCl into DMPC liposomes over the temperature range of 5-40oC is predominantly entropically controlled. A linear relationship was observed between ?S (W/L) and ?H (W/L) both below and above the Tc. However a relatively poor correlations were observed between ?G (W/L) and ?H(W/L) as well as between ?G(W/L) and ?S(W/L). ?G (W/L) values for all CPZ-HCl concentrations studied were negative indicating that the partitioning of CPZ-HCl into DMPC liposomes over the temperature range of 5o-40oC is predominantly entropically controlled. Log K values were observed to increase linearly as a function of log molar CPZ-HCl at concentrations known to cause anesthesia, reflecting a possible relationship between the drug anesthetic potency in-vivo and its ability to partition into phospholipid bilayers.


Cite this article:
Farah Hamad Farah. The Thermodynamic parameters of Chlorpromazine hydrochloride partitioning into Dimyrstoylphosphatidylcholine liposomes. Research J. Pharm. and Tech. 2020; 13(12):5716-5720. doi: 10.5958/0974-360X.2020.00995.6


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