Ranjit V. Gadhave, Bhanudas S. Kuchekar
Ranjit V. Gadhave1,2*, Bhanudas S. Kuchekar1,2
1Department of Pharmaceutical Chemistry, MAEER’s Maharashtra Institute of Pharmacy, Kothrud, Pune - 411038, Maharashtra, India.
2School of Pharmacy, MIT World Peace University, Kothrud, Pune - 411 038, Maharashtra, India.
Volume - 13,
Issue - 12,
Year - 2020
The present work describes biological evaluation of target molecules designed by molecular docking with 4h1j protein using Autodock Vina docker. Designed novel benzothiazole and coumarin based 6-(3, 5-dimethylpyrazol-1-yl) pyridazin-3-one derivatives were synthesized by condensation of substituted 6-(3,5-dimethylpyrazol-1-yl)pyridazin-3(2H)-one with substituted 2-amino benzothiazoles, substituted 2-oxo-2H-chromene-3-carbonyl chloride or 4-(bromomethyl)-2H-chromen-2-one. Synthesized compounds were characterized by spectral analysis and screened for antioxidant activity using 1, 1-diphenyl-2-picrylhyrazyl radical scavenging, Hydrogen peroxide scavenging and ferric reducing antioxidant power method. The compounds 5c and 9b showed more antioxidant potential and other compounds showed moderate to less activity as compared to standard Ascorbic acid and Butylated hydroxyl toluene.
Cite this article:
Ranjit V. Gadhave, Bhanudas S. Kuchekar. Design, Synthesis, Characterization and Antioxidant activity of Novel Benzothiazole and Coumarin based 6-(3, 5-dimethylpyrazol-1-yl) pyridazin-3-one Derivatives. Research J. Pharm. and Tech. 2020; 13(12):5661-5667. doi: 10.5958/0974-360X.2020.00986.5
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