Extensive research on natural medicine provides substantial evidence on safety of phytochemical thus it has been accepted worldwide to use natural product in management of chronic diseases. Flame of forest (Butea monosperma) belonging to family fabaceae, is rich in valuable secondary metabolites. Flavonoids are among the important key ingredient found in almost all medicinal plant and have tremendous effect in many diseases and thus are used in traditional system of medicine like Arurveda since many years. Butin, Butrin, isobutrin and butein are most important flavonoids found in abundance in flower and bark of B. monosperma. In this review we have focused on the four flavonoids and their biological importance. They are primarily used as anti-cancerous agent, apoptotic factor, anti-inflammatory agent, sensitizer, antibacterial, protein synthesis inducer, immuno-modulatory agent and a potent signal transducer.
Cite this article:
Shweta Singh Chauhan, Pramod Kumar Mahish. Flavonoids of the flame of forest- Butea monosperma. Research J. Pharm. and Tech. 2020; 13(11):5647-5653. doi: 10.5958/0974-360X.2020.00984.1
Shweta Singh Chauhan, Pramod Kumar Mahish. Flavonoids of the flame of forest- Butea monosperma. Research J. Pharm. and Tech. 2020; 13(11):5647-5653. doi: 10.5958/0974-360X.2020.00984.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-11-99
1. Shrama AK and Deshwal N. An overview: On Phytochemicals and Pharmaceutical Studies of Butea monosperma. International Journal of Pharma Tech Research. 2011; 3(3): 864-871
2. Fageria D. and Rao DV. A Review on Butea monosperma (Lam) kuntze: A Great Therapeutic valuable Leguminous Plants. International Journal of Science and Research Publications. (2015); 5(6): 1-9.
3. Madhavi A. An overview of Butea monosperma (Flame of forest). World Journal of Pharmacy and Pharmaceutical Science. 2013, 3(1): 307- 319
4. Mishra A, Verma S and Mishra AP. A plant review: Butea monosperma (Lam.) Kuntze. Research Journal of Pharmaceutical, Biological and Chemical Science. 2012; 3(1): 700-714.
5. More S, Jadav VM and Kadam VJ. A Comprehensive review on Butea Monosperma: A Valuable traditional plant. International Journal of Botany Study. 2018; 3(2): 65-71.
6. Reddy CS, Murthy EN, Reddy KN and Raju V. Butea monosperma (Lam.) Var. Lutea (Witt.): A Little Known Taxon of India Needs Immediate conservation. 2014; 12: 292-294.
7. Hitesh RP and Patel RS. Butea monosperma (Lam.) var. lutea (Witt) (Fabaceae): A news species record from Gujarat state, India. International Journal of Current Microbiology and Applied Science. 2015; 4(6): 867-869.
8. Shrirao AV, Kochar NI and Chandewar AV. Butea monosperma: An ornamental plant to precious herb. International Journal of Pharmaceutical and Biological Archive.2017; 8(5): 1-9.
9. Rai G, Rajak P, Sandhu N, Vasudeva N and Jindal S. Butea monosperma (Lam.) Kunze: A Review. International Research Journal of Pharmacy. 2011;2(7): 98-108.
10. Sarkar B. et al. Invitro free radical scavenging activity of Butea monosperma leaf extract. Journal of Advanced Pharmacy Education and Research. 2015; 5(3): 103-106.
11. Tuppad D S and Shishupala S. (2013). Endophytic microbiota of medicinal plant Butea monosprma. International Journal of Current Microbiology and Applied Science.2013; 2(12): 615-627.
12. BurliDA and Khade AB. A comprehensive review on Butea monosperma (Lam) Kuntze. Pharmacological review.2007; 1(2): 94-99.
13. Muthuswami R and Senthamarai R. Anatomical investigation of flower of Butea moosperma. Ancient Science of Life. 2014; 34(2): 73-79.
14. Sehrawat A and Kumar V. Butein impart free radical scavenging activity, antioxidant and proapoptotic properties in the flower extract of Butea monosperma. Bio Cell. 2012; 36(2): 63-71.
15. Mohammad T. et al. Evaluation of antibacterial and antioxidant activity of ethanolic extract of Butea monosperma. World Journal of Pharmaceutical Research. 2018; 7(3): 730-740.
16. Sindhia V R, and Bairrwa R. Plant Review: Butea monosperma. International Journal of Pharmaceutical and Clinical Research. 2010; 2(2).90-94.
17. Suguna L, Miriyala S and Panchatcharam M. Efficacy of Butea monosperma on dermal wound healing in rats. International Journal of Biochemistry Cell Biology. 2005; 37(3): 566-73.
18. Mazumdar PM, Das MK and Das S. Butea monosperma (LAM). Kumtze-A Comprehensive review. International Journal of Pharmaceutical Science and Nanotechnology.2011; 4(2): 1390-139.
19. Tiwari P, Jena S, Sahu PK. Butea monosperma: Phytochemistry and Pharmacology. Acta Scietific Pharmaceutical Science.2019; 3(4): 19-26.
20. Lavhale MS and Mishra SH. Evaluation of free radical scavenging activity of Butea monosperma Lam. Indian Journal Exp Biol. 2007; 45(4): 376-384.
21. Sharma N and Shukla S. Hepatoprotective potential of aqueous extract of Butea monosperma against CCl4 induced damage in rats. Exp Toxicol Pathol. 2011; 63(7): 671-676.
22. Iqbal Z, Lateef M, Jabbar A, Gayur MN, Gillani AH. In vivo anthelmintic activity of Butea monosperma againt Trichostrongylid nematode in sheep. Fitoterapia.2006; 77(2): 137-140.
23. Gurav SS, Gulkari VD, Duragkar NJ and Patil AT. Antimicrobial action of Butea monosperma Lam. Gum. Iranian Journal of Pharmacology and Therapeutics. 2008; 7: 21-24.
24. Szliszka E et al. Chalcones Enhances TRAIL- Induced Apoptosis in prostate Cancer Cells. International Journal of Molecular Science. 2011; 11(1): 1-13.
25. Gupta SR, Ravindranath B, Seshadri TR. 1970. Phytochemistry. 9, 2231-2235.
26. Wagner H. et al. Isobutrin and Butrin, the Antihepatotoxic principal of Butea monosperma flower. Planta Medica. (1986); 77-79.
27. Agarkar S A. et al. Isobutrin from Butea monosperma (flame of forest): A promising new sensitizer belonging to chalconeclass. Applied Material and Interfaces.2011;18(1): 2440-2444.
28. Rasheed Z, Akhtar N, Khan A, Khan KA, and Haqqi TM. Butrin, Isobutrin, and Butein from Medicinal Plant Butea monosperma Selectively Inhibit Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Nuclear Factor-κB in Activated Human Mast Cells: Suppression of Tumor Necrosis Factor-α, Interleukin (IL)-6, and IL-8. The Journal of Pharmacology and Experimental Therapeutics. 2010; 333(2): 354-362.
29. Bhargava SK. Estrogenic and post coitalanticonceptive activity in rats of butin isolated from Butea monosperma. Journal of Ethanopharmalogy.1986; 18(1): 95-101.
30. Liao W, Liu J, Zhang D, Huang W and Chen R. Butein inhibited in Vitro Hexokinase -2 mediated tumor glycolysis in hepatocrcinoma by blocking epidermal growth factor receptor. Medical Science. 2018; 24: 3283-3292.
31. Yang EB et al. Inhibition of epidermal growth factor tyrosine kinase by chalcone derivatives. Biochemistry Biophysics Acta- Protein Structure and Molecular Biology. 2001; 1550(2): 144-152.
32. Wang Y, Chan FL, Chen S and Leung LK. The plnat polyphenol butein inhibits testosterone induced proliferation in breast cancer cell expressing aromatase. Life Science. 2005;77(1): 39-50
33. Fiander H and Schneider H. Dietary ortho phenol that induces glutathione S transferase and increase the resistant of cells to hydrogen peroxide are potential cancer chemo preventives that act by two mechanism that alleviation of oxidative stress and the detoxification of mutagenic xenobiotics. Cancer Letter. 2000; 156: 117-224.
34. Sehrawat A and Sultana S. Chemoprevention by Butea monosperma of hepatic carcinogenesis and oxidative damage in male wistar rats. Asian Pacific Journal of Cancer Prev.2006; 7(1):140-148.
35. Subramaniyam B. et al. Effect of sodium salt of Butrin, a novel compound from Butea monosperma flower on suppressing the expression of SIRT 1 and Aurora B kinase mediated apoptosis in colorectal cancer cells. Biomedicine and Pharmacotherapy. 2017; 90: 402-413.
36. Zang R, Chae S, Lee J H and Hyun J W. Cytoprotective effect of butin against oxidative stress is mediated by the upregulation of manganese superoxide dismutase expression through p13K/ Akt/ Nrf 2 dependent pathway. Journal of Cellular Biochemistry.2012; 113: 1987-1997.
37. Duan J. et al. Protective effect of butin against ischemia/ reperfusion induced myocardial injury in diabetic mice: involvement of the AMPK/ GSK-3 beta/ Nrf 2 signaling pathway. Scientific Report 7. 2017; 41491. 1-13.
38. Zhang R, Chae S, Kang KA, Piao MJ. Protective effect of butin against hydrogen peroxide induced apoptosis by scavenging reactive oxygen species and activating antioxidant enzymes. Molecular and Cellular Biochemistry. 2008; 1(2): 33-42.
39. Na-Young Kim, Hyun-OckPae, Gi-Su Oh, Tae-Hyun Kang, Youn-Chul Kim, Hyun-Yul Rhew. Butein, a Plant Polyphenol, Induces Apoptosis Concomitant with Increased Caspase-3 Activity, Decreased Bcl-2. Expression and Increased Bax Expression in HL-60 Cells. Pharmacology and Toxicology.2001; 88: 261–266.
40. Zhang R, Chae S, Lee J H, and Hyun J W. Cytoprotective effect of butin against oxidative stress is mediated by the upregulation of manganese superoxide dismutase expression through p13K/ Akt/ Nrf 2 dependent pathway. Journal of Cellular Biochemistry. 2012; 113: 1987-1997.
41. Chung CH.etal.Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Hindawi Publishing Corporation. 2013; 1-11.
42. Brown AK, Papaemmouil A, Bhowruth V, Bhatt A, Dover LG and Besra GS. 2007. Flavonoids inhibitor as novel antimycobacterial agent targeting Rv0636, a putative dehydrogenase enzyme in Mycobacterium tuberculosis fatty acid synthesis.
43. Moon DO, Kim MO, Chori YH, Huyan JW, Change YH, and Kim GY. Butein induces G2/M phase arrest and apoptosis in human hepatoma cancer cell through ROS generation. Cancer Letter. 2010288, 204-213.
44. Huo SX, Wang Q, Liu XM, Ge CH, Gao L, Peng XM and Yan M. The effect of butin in vitilligo mouse model induced by Hydroquinone. Phytochemistry Research. 2017; 31(5): 740-746.