Author(s): Anamika Gautam, Harmeet Kaur, Arvinder Kaur, Pankaj Kumar Prashar, Ankita Sood, Sachin Kumar Singh, Monica Gulati, Narendra Kumar Pandey, Bimlesh Kumar

Email(s): bimlesh1Pharm@gmail.com , bimlesh.12474@lpu.co.in.

DOI: 10.5958/0974-360X.2020.00980.4   

Address: Anamika Gautam, Harmeet Kaur, Arvinder Kaur, Pankaj Kumar Prashar, Ankita Sood, Sachin Kumar Singh, Monica Gulati, Narendra Kumar Pandey, Bimlesh Kumar*
School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Tinospora Cordifolia (TC) (family: Menispermaceae) is a medicinal plant with multi health benefits. This plant is reported to possess anti-diabetic, anti-periodic, anti-spasmodic, anti-inflammatory, anti-arthritic, anti-oxidant, anti-allergic, anti-stress, anti-leprotic, anti-malarial, hepato-protective, immunomodulatory and anti-neoplastic effects. Each part of this plant and its various species are effective in the treatment of various disorders. Alpha-D-glucan of this plant causes activation of immune system through activation of macrophage that occur by TLR6 signaling, NF kappa B translocation and cytokine production. Its extract is antagonizing the effect of Histamine, 5-HT, bradykinin, PGE1 in smooth muscle of rat. Scientific reports stablished that, LD50 value was higher than 1 g/kg in case of oral administration in experimental animal apart from that no abnormalities were detected in liver and renal function of rats received 100mg/kg for 12 weeks. 3g/kg of its administration did not show any adverse effects or animal death in Wistar albino rats undergone acute toxicity studies. TC reported safe in a phase I study. Clinically it was reported that its aqueous extract decreases the toxic effects of alcohol and help to modulate testosterone and cholesterol biosynthesis. Hence present review focus on preclinical and clinical importance of TC and its bioactive compounds.


Cite this article:
Anamika Gautam, Harmeet Kaur, Arvinder Kaur, Pankaj Kumar Prashar, Ankita Sood, Sachin Kumar Singh, Monica Gulati, Narendra Kumar Pandey, Bimlesh Kumar. Tinospora cordifolia: A Successful Story from Botanical background to Pharmaceutical Product. Research J. Pharm. and Tech. 2020; 13(11):5620-5630. doi: 10.5958/0974-360X.2020.00980.4


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