Poornima D Adpekar, Annamalai Rama, Usha Rani, Anup Naha
Poornima D Adpekar1, Annamalai Rama1, Usha Rani2, Anup Naha1*
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences.
2Department of Health Innovation, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal – 576104, Karnataka, India.
Volume - 13,
Issue - 11,
Year - 2020
Recent research in biomedical science specifically in the area of electrospinning nanofibers have been documented to have a great value addition in terms of its various applications. The basic principle of fabricating the nanofibers involves the use of electric force to draw charged threads to convert it into nanoparticles. BCS class II drug molecules having the solubility issues, affects the bioavailability of the formulation, is a big challenge in recent years. The use of electrospinning nanofiber technology can be used as an effective platform to enhance their bioavailability and to achieve a controlled release of drug in an effective manner. The various biomedical applications of these nanofibers involve specifically in the area of drug delivery, tissue engineering and enzyme immobilization. This article aims to summarize the importance of electrospun nanofibers with its fabrication techniques, processing parameters and various applications in the field of biomedical sciences.
Cite this article:
Poornima D Adpekar, Annamalai Rama, Usha Rani, Anup Naha. Electrospun Nanofibres and Their Biomedical Applications. Research J. Pharm. and Tech. 2020; 13(11):5569-5575. doi: 10.5958/0974-360X.2020.00972.5
Poornima D Adpekar, Annamalai Rama, Usha Rani, Anup Naha. Electrospun Nanofibres and Their Biomedical Applications. Research J. Pharm. and Tech. 2020; 13(11):5569-5575. doi: 10.5958/0974-360X.2020.00972.5 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-11-87
1. Karakas H. Electrospinning of Nanofibers and Their Applications. Istanbul Tech Univ Text Technol Des Fac. 2015;(August):1–35.
2. Huang ZM, Zhang YZ, Kotaki M, Ramakrishna S. A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol. 2003;63(15):2223–53.
3. Bhattarai RS, Bachu RD, Boddu SHS, Bhaduri S. Biomedical applications of electrospun nanofibers: Drug and nanoparticle delivery. Pharmaceutics. 2019;11(1).
4. Nayak R, Padhye R, Kyratzis IL, Truong YB, Arnold L. Recent advances in nanofibSre fabrication techniques. Text Res J. 2012;82(2):129–47.
5. Yu D-G, Zhu L-M, White K, Branford-White C. Electrospun nanofiber-based drug delivery systems. Health (Irvine Calif). 2009;01(02):67–75.
6. Vlachou M, Siamidi A KS. Electrospinning and drug delivery. Available from: https://www.intechopen.com/books/advanced-biometric-technologies/liveness-detection-in-biometrics
7. Bera B. Literature Review on Electrospinning Process (A Fascinating Fiber Fabrication Technique). Imp J Interdiscip Res (IJIR. 201;2(8):972–84.
8. Wang X, Kim YG, Drew C, Ku BC, Kumar J, Samuelson LA. Electrostatic Assembly of Conjugated Polymer Thin Layers on Electrospun Nanofibrous Membranes for Biosensors. Nano Lett. 2004;4(2):331–4.
9. Akhgari A, Shakib Z, Sanati S. A review on electrospun nanofibers for oral drug delivery. Nanomedicine J. 2017;4(4):197–207.
10. Haider A, Haider S, Kang IK. A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology. Arab J Chem. 2018;11(8):1165–88.
11. Singh S. World Journal of Pharmaceutical Research. Age (Omaha). 2015;20(8):60yrs.
12. Bhardwaj N, Kundu SC. Electrospinning: A fascinating fiber fabrication technique. Biotechnol Adv. 2010;28(3):325–47.
13. Pillay V, Dott C, Choonara YE, Tyagi C, Tomar L, Kumar P, et al. A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. J Nanomater. 2012;2013(1)-1-22
14. Sukigara S, Gandhi M, Ayutsede J, Micklus M, Ko F. Regeneration of Bombyx mori silk by electrospinning - Part 1: Processing parameters and geometric properties. Polymer (Guildf). 2003;44(19):5721–7.
15. Baumgarten PK. Electrostatic spinning of acrylic microfibers. J Colloid Interface Sci. 1971;36(1):71–9.
16. Koski A, Yim K, Shivkumar S. Effect of molecular weight on fibrous PVA produced by electrospinning. Mater Lett. 2004;58(3–4):493–7.
17. Lin Weng JX. Smart Electrospun Nanofibers for Controlled Drug Release: Recent Advances and New Perspectives. 2017;371(14):1280–3.
18. Yang Q, Zhenyu LI, Hong Y, Zhao Y, Qiu S, Wang CE, et al. Influence of solvents on the formation of ultrathin uniform poly (vinyl pyrrolidone) nanofibers with electrospinning. J Polym Sci Part B Polym Phys. 2004;42(20):3721–6.
19. Megelski S, Stephens JS, Bruce Chase D, Rabolt JF. Micro- and nanostructured surface morphology on electrospun polymer fibers. Macromolecules. 2002;35(22):8456–66.
20. Valencia Jacobs, Rajesh D. Anandjiwala MM. The Influence of Electrospinning Parameters on the Structural Morphology and Diameter of Electrospun Nanofibers. J Appl Polym Sci. 2010;116(5):2658–67.
21. Fang J, Niu HT, Lin T, Wang XG. Applications of electrospun nanofibers. Chinese Sci Bull. 2008;53(15):2265–86.
22. Gao Y, Truong YB, Zhu Y, Louis Kyratzis I. Electrospun antibacterial nanofibers: Production, activity, and in vivo applications. J Appl Polym Sci. 2014;131(18):9041–53.
23. Daniel J Smith, Darrell H Reneker, Albert T McManus, Heidi L Schreuder-GIbson, Charlene Mello MSS. Electrospun Fibers and an apparatus therefor. Vol. US00675345. 2004.
24. Khil MS, Cha D Il, Kim HY, Kim IS, Bhattarai N. Electrospun Nanofibrous Polyurethane Membrane as Wound Dressing. J Biomed Mater Res - Part B Appl Biomater. 2003;67(2):675–9.
25. Spadaro JA, Berger TJ, Barranco SD, Chapin SE, Becker RO. Antibacterial effects of silver electrodes with weak direct current. Antimicrob Agents Chemother. 1974;6(5):637–42.
26. Jeong EH, Yang J, Youk JH. Preparation of polyurethane cationomer nanofiber mats for use in antimicrobial nanofilter applications. Mater Lett. 2007;61(18):3991–4.
27. Rani K, Paliwal S. A Review on Targeted Drug Delivery: its Entire Focus on Advanced Therapeutics and Diagnostics. Sch J Appl Med Sci. 2014;2(1):328–31.
28. Chen Z, Mo X, Qing F. Electrospinning of collagen-chitosan complex. Mater Lett. 2007;61(16):3490–4.
29. Ji Y, Ghosh K, Li B, Sokolov JC, Clark RAF, Rafailovich MH. Dual-syringe reactive electrospinning of cross-linked hyaluronic acid hydrogel nanofibers for tissue engineering applications. Macromol Biosci. 2006;6(10):811–7.
30. Kenawy ER, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH, et al. Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly (lactic acid), and a blend. J Control Release. 2002;81(1–2):57–64.
31. Ramasamy SK. Structure and Functions of Blood Vessels and Vascular Niches in Bone. Stem Cells Int. 2017;2017(Figure 1).
32. Sivaraj KK, Adams RH. Blood vessel formation and function in bone. Dev. 2016;143(15):2706–15.
33. Vaz CM, van Tuijl S, Bouten CVC, Baaijens FPT. Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique. Acta Biomater. 2005;1(5):575–82.
34. Telemeco TA, Ayres C, Bowlin GL, Wnek GE, Boland ED, Cohen N, et al. Regulation of cellular infiltration into tissue engineering scaffolds composed of submicron diameter fibrils produced by electrospinning. Acta Biomater. 2005;1(4):377–85.
35. Amini AR, Laurencin CT, Nukavarapu SP. Bone tissue engineering: Recent advances and challenges. Crit Rev Biomed Eng. 2012;40(5):363–408.
36. Wong HM, Chu PK, Leung FKL, Cheung KMC, Luk KDK, Yeung KWK. Engineered polycaprolactone-magnesium hybrid biodegradable porous scaffold for bone tissue engineering. Prog Nat Sci Mater Int. 2014;24(5):561–7.
37. Sun Y, Cheng S, Lu W, Wang Y, Zhang P, Yao Q. Electrospun fibers and their application in drug controlled release, biological dressings, tissue repair, and enzyme immobilization. RSC Adv. 2019;9(44):25712–29.