Gul-e-Saba Chaudhry, Muhammad Naveed Zafar, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad
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Gul-e-Saba Chaudhry1*, Muhammad Naveed Zafar2, Yeong Yik Sung1, Tengku Sifzizul Tengku Muhammad1
1Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Malaysia.
2Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Volume - 13,
Issue - 11,
Year - 2020
Natural products play an important role in the treatment of a variety of diseases. Several medicinal plants were screened to study phytochemistry and biological activity against various diseases. Amongst the coastal medicinal plants, Vitex rotundifolia (beach vitex) possessed potential phytochemical constituents. Chemical constituents of Vitex rotundifolia include phenolics, flavonoids, and terpenoids as major compounds present. Various flavonoids such as Vitexicarpin, 4-hydroxybenzoic acid methyl ester, vanillic acid methyl ester, 4-hydroxy benzaldehyde, luteolin, and artemetin were isolated from the leaves of Vitex rotundifolia. Similarly, different types of terpenoids that have been isolated from Vitex rotundifolia include Eurostoside, Iridolactone, Viteoid I, Viteoid II, Iridoid compounds such as 10-O-vanilloylaucubin, 10-O-p hydroxybenzoylaucubin and aucubin, Vitexifolin A, Vitexifolin B, Viterotulin A, and Viterotulin B have been isolated from Vitex rotundifolia. The pharmacological importance of Vitex rotundifolia is due to various biological activities such as anti-cancer, anti-inflammatory, anti-proliferative, anti-bacterial and anti-oxidant activities. Therefore, plant species Vitex rotundifolia, from genus Vitex was selected to discuss the phytochemicals present and its biological activity. However, remarkable anticancer activities of several compounds isolated from Vitex rotundifolia enriches its cancer therapeutics potential and demands for further exploration of mode and mechanism of cell death as part of preclinical trials.
Cite this article:
Gul-e-Saba Chaudhry, Muhammad Naveed Zafar, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad. Phytochemistry and Biological activity of Vitex rotundifolia L. Research J. Pharm. and Tech. 2020; 13(11):5534-5538. doi: 10.5958/0974-360X.2020.00966.X
1. Koehn FE and Carter GT The evolving role of natural products in drug discovery. Nat Rev Drug Discov 2005; 4: 206–220.
2. Monks NR, Lerner C, Henriques AT, Fabiane M, Farias FM, Schapoval EES, Suyenaga ES, da-Rocha AB, Schwartsmann G and Mothes B Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil. Exp Mar Bio Ecol 2002; 281: 1-12.
3. Boopathy NS and Kathiresan K Anticancer drugs from marine flora: An overview. J Oncol 2010; 214186:18.
4. Garbi MI, Osman EE, Kabbashi AS., Saleh MS., Yuosof YS et al Cytotoxicity of Vitex trifolia leaf extracts on MCF-7 and Vero cell lines. JSIR 2015; 4: 89-93.
5. Meena AK, Niranjan US, Rao MM, Padhi MM and Babu R A review of the important chemical constituents and medicinal uses of Vitex genus. AJTM 2011, 6, 54-60.
6. Santhosh SB, Chandrasekar MJN, Kaviarasan L, Deepak P, Silambarasan T, Gayathri B, Natarajan D. Chemical Composition, Antibacterial, Anti-oxidant and Cytotoxic properties of Green Synthesized Silver Nanoparticles from Annona muricata L. (Annonaceae). Research J. Pharm. and Tech. 2020; 13(1):33-39.
7. Pinnamaneni R. Cell Viability Studies and Anti-cancerous activity Evaluation of Pomegranate (Punica granatum L) extract . Research J. Pharm. and Tech. 2020; 13(1): 303-307.
8. Mohanty S, Pal A, Chandra SS. Flavonoid as Nutraceuticals: A Therapeutic approach to Rheumatoid Arthritis. Research J. Pharm. and Tech 2020; 13(2):991-998.
9. Vinubharathi B, Mahalakshmi V, Muthukumar NJ, Suresh R, Banumathi V. Screening of In vitro Antioxidant Activity of Methanolic extract of Maruthampattai kudineer- A Siddha Polyherbal Preparation. Research J. Pharm. and Tech 2019; 12(1): 219-222.
10. Karpagam T, Jannathul F, Revathy, Priya S, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad. Anti-Cancer Activity of Aloe Vera Ethanolic Leaves Extract against In vitro Cancer Cells. Research J. Pharm. and Tech. 2019; 12(5):2167-2170.
11. Geetha S, Rajeswari S. A Preliminary Study on Phytochemical Screening, Proximate Analysis and Anti-Bacterial Activities of Andrographis paniculata Seed Extract. Research J. Pharm. and Tech. 2019; 12(5):2083-2088.
12. Deeparani U, Jayakumari S. In vitro Anti-Cancer Study of Vitis viniferae, Ixora coccinea and Piper longum Extract on Human Prostate Carcinoma Cells. Research J. Pharm. and Tech 2019; 12(9):4485-4488.
13. Fadilah A, Wiyono L, Edina BC, Rahmawati RA, Erlina L, Tedjo A, Paramita RI. In Silico Study and In Vitro test of Extract Kaempferia pandurata Roxb. as Anti ER (+) Breast Cancer Cell Line MCF-7. Research J. Pharm. and Tech. 2019; 12(5):2391-2395.
14. Bakka C, Smara O, Hadjadj M, Dendougui H, Mahdjar S, Benzid A. In vitro Anti-inflammatory activity of Pistacia atlantica Desf. extracts. Asian J. Research Chem. 2019; 12(6):322-325.
15. Kumar AS, Ramaswamy NM. Anti-Inflammatory activity of Sesbania grandiflora (Fabaceae). Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 214-215.
16. Gul-e-Saba, Murni Ismail, Noraznawati Ismail, Habsah, TST Muhammad Induction of Apoptosis by Aaptos sp., fractions in human breast cancer. Int J Res Pharm Sci 2018; 9(2): 328-237.
17. Hudaya T, Gul-e-Saba, Taib, M Ismail N, Mohammad TST. Methanol extract of four selected marine sponges induces apoptosis in human breast cancer cell line, MCF-7. Int J Res Pharm Sci 2017; 8(3): 667-675.
18. Chaudhry GS, Murni NIK, Zafar MN, Habsah M, Andriani Y, Ismail N, TST Muhammad and Sung YY. Induction of apoptosis by Stichopus chloronotus and Holothuria nobilis fractions in the human cervical cancer cell line, HeLa. Int J Res Pharm Sci 2020; 11: 1 (Feb. 2020), 1238-1247. DOI:https://doi.org/10.26452/ijrps.v11i1.1964.
19. Chaudhry GS, Nur Khairina Ahmed Sohimi, Habsah Mohamad, Muhammad Naveed Zafar, Aziz Ahmed, Noor Azlina Kamaruding, Yeong Yik Sung, Tengku Sifzizul Tengku Muhammad. Induction of apoptosis by selected Xylocarpus sp., fractions in the human cervical cancer cell line, HeLa Int J Res Pharm Sci 2020 (accepted) In press
20. Chavan SS, Damale MG, Shamkuwar PB and Pawar DP Traditional medicinal plants for anticancer activity. Int J Curr Pharm Res 2013; 5: 50-54.
21. Jan R, and Chaudhry GS Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv Pharm Bull 9(2); 2019: 205-218.
22. Gul-e-Saba, Abdah A, AA. Hyaluronan-mediated CD44 Receptor Cancer Cells Progression and the Application of Controlled Drug-delivery System. Int J Curr Chem 2010; 1(4): 245-265.
23. Oberlies NH and Kroll DJ Camptothecin and taxol: historic achievement in natural products research. J Nat Prod 2004; 67: 129–135.
24. Gul-e-Saba, AA. Polymeric nanoparticle mediated targeted drug delivery to cancer cells. In: biotechnology and bioinformatics, pp 1-34.
25. Gul-e-Saba, Abdah A, AA. Cytotoxic Effects of Drug-loaded Hyaluronan-Glutaraldehyde Cross-Linked Nanoparticles and the Release Kinetics Modeling. J Adv Chem Eng 2014; 1:104.
26. Beutler JA Natural Products as a Foundation for Drug Discovery. Curr Protoc Pharmaco 2009; 46: 1–9.
27. Rani A and Sharma A The genus Vitex: A review. Pharmacogn Rev 2013; 7: 188–198.
28. Yao JL, Fang SM, Liu R, Oppong MB, Liu EW et al. A Review on the terpenes from genus Vitex. Molecules 2016; 21: 1179.
29. Cousins MM, Briggs J and Whitwell T, Beach Vitex (Vitex rotundifolia): Medicinal properties, biology, invasive characteristics and management options. J Environ Hortic 2017; 35: 128–137.
30. Ohtsuki T, Shoda T, Kaneko Y and Setoguchi H Development of microsatellite markers for Vitex rotundifolia (verbenaceae), an endangered coastal plant in Lake Biwa, Japan, Appl Plant Sci 2014; 2: 4-7.
31. Cousins MM, Briggs J, Gresham C, Whetstone J and Whitwell T, Beach Vitex (Vitex rotundifolia): An invasive coastal species. Invasive Plant Sci Manag 2010; 3: 340-345.
32. Yoshiokaa T, Inokuchib T, Fujiokac S and Kimurab Y Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z. Naturforsch. B 2004;59: 509-514.
33. Hu Y, Zhang QY, Hou TT, Xin HL, Zheng HC et al. Estrogen-like activities in Vitex species from China determined by a cell based proliferation assay. Die Pharmazie 2007; 62: 872–875.
34. Iwashina T, Setoguchi H and Kitajima J Flavonoids from the leaves of Vitex rotundifolia (Verbenaceae), and their qualitative and quantitative comparison between coastal and inland populations. Bull Natl Mus Nat Sci Ser B Bot 2011; 37: 87–94.
35. Kobayakawa J, Sato-Nishimori F, Moriyasu M andMatsukawa Y G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from viticis fructus (Vitex rotundifolia Linn.). Cancer Lett 2004; 208: 59-64.
36. Okuyama E, Suzumura K, Yamazaki M Pharmacologically active components of Viticis Fructus (Vitex rotundifolia). I. The components having vascular relaxation effects. J Nat Med 1998; 52: 218-225.
37. Yamasaki T, Kawabata T, Masuoka C, Kinjo J, Ikeda T, Nohara T, Ono M Two new lignin glucosides from the fruit of Vitex cannabifolia. J Nat Med 2008; 62: 47–51.
38. Kouno I, Inoue M, Onizuka Y, Fujisaki T, Kawano N Iridoid and phenolic glucoside from Vitex rotundifolia. Phytochemistry 1988; 27: 611–612.
39. One M, Ito Y, Kubo S, Nohara T Two new iridoids from Viticis trifoliae fructus (Fruit of Vitex rotundifolia L.) Chem Pharm Bull 1997; 45: 1094–1096.
40. Kim DK Antioxidative Constituents from the Twigs of Vitex rotundifolia. Biomol Ther 2009; 17: 412-417.
41. Ono M, Yanaka T, Yamamoto M, Ito Y, Nohara T New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. J Nat Prod 2002; 65: 537–541.
42. Lee C, Lee JW, Jin QH, Lee HJ, Lee SJ Lee D, Lee MK, Lee CK, Hong JT, Lee MK, Hwang BY Anti-inflammatory constituents from the fruits of Vitex rotundifolia. Bioorg Med Chem Lett 2013; 23: 6010–6014.
43. Kawazoe K, Yutani A, Tamemoto K, Yuasa S, Shibata H, Higuti T and Takaishi Y Phenylnaphthalene compounds from the subterranean part of Vitex rotundifolia and their antibacterial activity against methicillin-resistant Staphylococcus aureus. J Nat Prod 2001; 64: 588-91.
44. Kawazoe K, Yutani A, Takaishi Y Aryl naphthalenes norlignans from Vitex rotundifolia, Phytochemistry 1999; 52: 1657-1659.
45. Chaudhry GS, Jan R, Habsah M, Mohammad T.S.T Vitex rotundifolia fractions induce apoptosis in the human breast cancer cell line, MCF-7, via extrinsic and intrinsic pathways. Res Pharma Sci 2019a;14(3): 273-285.
46. Chaudhry GS, Jan R, Zafar MN, Habsah M, Muhammad TST (2019b) Vitex rotundifolia fractions induced apoptosis in human breast cancer T-47D cell line via activation of extrinsic and intrinsic pathway. Asian PacJCancerPrev2019b;20(12):3555-3562.
47. Ko WG, Kang TH, Lee SJ, Kim NY, Kim YC, Sohn DH, Lee BH Polymethoxyflavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells. Food Chem Toxicol 2000; 38: 861–865.
48. Xue G, Gang C Isolation, identification and cytotoxic activity analysis of polymethoxylated flavonoids from Vitex rotundifolia fruit. Journal of Plant ResourcesandEnvironment2015;24:118-120.
49. Meng FM, Yang JB, Yang C, Jiang Y, Zhou Y, Yu B and Yang H Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. Asian Pac J Cancer Prev 2012; 13: 6369-6374.
50. Song X, Zhang Y, Wang X, Zhang W, Wang Z, Zhang F, Zhang Y, Lu J, Mei J, Hu Y, Chen L, Li H, Ye Y, Liu Y and Gu J Casticin induces apoptosis and G0/G1 cell cycle arrest in gallbladder cancer cells. Cancer Cell Int 2017; 17: 9.
51. Zhou Y, Peng Y, Mao QQ, Li X, Chen MW, Su J, Tian L. Mao NQ, Long LZ, Quan MF, Liu F, Zhou SF and Zhao YX Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells. Asian Pac J Trop Med 2013; 2013: 372-378.
52. Shen J K, Du H P, Yang M, Wang Y G and Jin J Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. Ann Hematol 2009; 88: 743-752.
53. Zeng F, Tian L, Liu F, Cao J, Quan M and Sheng X Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. Acta Biochim Biophys Sinica 2012; 44: 442-449.
54. Song YB, Zhou SH, Cui HS, Liu HN and Li LJ Casticin treatment inhibits squamous cell carcinoma cell proliferation and arrests cell cycle in S phase. Bangladesh J Pharmacol, 2016; 11: 206-211.
55. Ko WG, Kang TH, Lee SJ, Kim YC and Lee BH Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells. Phytother Res 2002; 16: 295–298.
56. Ko WG, Kang TH, Lee SJ, Kim YC and Lee BH Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Phytother Res 2001; 15: 535-7.
57. Jo KJ, Yoon MY, Lee MR, Cha MR The anticancer effect of extracts from Vitex rotundifolia on human colon carcinoma cell lines. Appl Biol Chem 2007; 50: 228-232.
58. Song HM, Park GH, Koo JS, Jeong HJ, Jeong JB Vitex rotundifolia fruit extract induces apoptosis through the downregulation of ATF3-mediated Bcl-2 expression in human colorectal cancer cells. Am J Chin Med 2017; 45: 901-915.
59. Song HM, Park GH, Park SB, Kim HS, Son HJ, Um Y, et al. Vitex rotundifolia fruit suppresses the proliferation of human colorectal cancer cells through down-regulation of Cyclin D1 and CDK4 via proteasomal-dependent degradation and transcriptional inhibition. Am J Chin Med 2018; 46: 191-207.
60. Hassoun SM, Abdel-Rahman N, Eladl EEI, El-Shishtawy MM Antiangiogenic activity of vitexicarpine in experimentally induced hepatocellular carcinoma: Impact on vascular endothelial growth factor pathway. Tumor Biol 2017; 1–11.
61. Bae EA, Han MJ, Kim NJ and Kim DH Anti-Helicobacter pylori activity of herbal medicines. Biol Pharm Bull 1998; 21: 990-2.
62. Watanabe K, Takada Y, Matsuo N, Nishimura H Rotundial, a new natural mosquito repellent from the leaves of Vitex rotundifolia. Biosci Biotechnol Biochem 1995; 59: 1979-80.
63. Miyazawa M, Shimamura H, Nakamura SI, Kameoka H, Antimutagenic activity of (+)-polyalthic acid from Vitex rotundifolia. J Agric Food Chem 1995; 43: 3012–3015.
64. Kondo Y, Sugiyama K, Nozoe S Studies on the constituents of Vitex rotundifolia L. fil Chem Pharm Bull 1986; 34: 4829-4832.