Author(s): Effan Cahyati Junaedi, Keri Lestari, Muchtaridi Muchtaridi

Email(s): muchtaridi@unpad.ac.id

DOI: 10.5958/0974-360X.2020.00961.0   

Address: Effan Cahyati Junaedi1,3, Keri Lestari2, Muchtaridi Muchtaridi*1
1Department of Medicinal Chemical and Chemical Analysis, Faculty of Pharmacy, Padjajaran University, Indonesia.
2Department of Pharmacology and Clincal Pharmacy, Faculty of Pharmacy, Padjajaran University, Indonesia.
3Department of Pharmaceutical Chemical Analysis, Faculty of Mathematics and Natural Science, Garut University, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Stevia is a sweet-taste shrub that containing secondary metabolites called steviol glycoside. The main steviol glycoside in Stevia rebaudiana Bertoni is stevioside that 200-300 times sweeter than sucrose, which is contained in large amounts. This compound has benefited as a low-calorie sweetener and some biological activities. Therefore, the use of stevioside in various fields is increasingly widespread. The increasing use of stevioside from Stevia rebaudiana Bertoni on various products makes the analysis of this compound become important. Sensitive analysis methods are needed for the quantification of stevioside. Various methods have been developed for quantitative analysis of stevioside that produce various values of precision, accuracy, and sensitivity. This paper aims to summarize and describe the current literature on quantitative methods for stevioside from Stevia rebaudiana Bertoni. So that a comparison can be made between several methods to get the most suitable method for quantitative analysis. In addition, this paper also looks at the extent to which the success of the existed methods at the last decade assessed from various validation parameters so that they can be considered in the development of further analysis methods.


Cite this article:
Effan Cahyati Junaedi, Keri Lestari, Muchtaridi Muchtaridi. Recent Quantitative Analysis of Stevioside from Stevia Rebaudiana (Bertoni): A Review. Research J. Pharm. and Tech. 2020; 13(11):5503-5509. doi: 10.5958/0974-360X.2020.00961.0


REFERENCES:
1.     Goyal SK, Samsher, Goyal RK. Stevia (Stevia rebaudiana) a bio-sweetener: A review. Int J Food Sci Nutr. 2010;61(1):1-10. doi:10.3109/09637480903193049
2.     Carakostas MC, Curry LL, Boileau AC, Brusick DJ. Overview: The history, technical function and safety of rebaudioside A, a naturally occurring steviol glycoside, for use in food and beverages. Food Chem Toxicol. 2008;46(7 SUPPL.):1-10. doi:10.1016/j.fct.2008.05.003
3.     Cacciola F, Delmonte P, Jaworska K, Dugo P, Mondello L, Rader JI. Employing ultra high pressure liquid chromatography as the second dimension in a comprehensive two-dimensional system for analysis of Stevia rebaudiana extracts. J Chromatogr A. 2011;1218(15):2012-2018. doi:10.1016/j.chroma.2010.08.081
4.     Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics. Regul Toxicol Pharmacol. 2008;51(1):37-41. doi:10.1016/j.yrtph.2008.02.006
5.     Lemus-Mondaca R, Vega-Gálvez A, Zura-Bravo L, Kong AH. Stevia rebaudiana Bertoni, source of a high-potency natural sweetener: A comprehensive review on the biochemical, nutritional and functional aspects. Food Chem. 2012;132(3):1121-1132. doi:10.1016/j.foodchem.2011.11.140
6.     Yadav SK, Guleria P. Steviol Glycosides from Stevia: Biosynthesis Pathway Review and their Application in Foods and Medicine. Crit Rev Food Sci Nutr. 2012;52(11):988-998. doi:10.1080/10408398.2010.519447
7.     Gardana C, Scaglianti M, Simonetti P. Evaluation of steviol and its glycosides in Stevia rebaudiana leaves and commercial sweetener by ultra-high-performance liquid chromatography-mass spectrometry. J Chromatogr A. 2010;1217(9):1463-1470. doi:10.1016/j.chroma.2009.12.036
8.     Yadav AK, Singh S, Dhyani D, Ahuja PS. A review on the improvement of stevia [ Stevia rebaudiana (Bertoni)]. Can J Plant Sci. 2011;91(1):1-27. doi:10.4141/cjps10086
9.     National C for BI. Stevioside, CID=442089. In: PubChem Database. https://pubchem.ncbi.nlm.nih.gov/compound/Stevioside. Accessed June 15, 2019.
10.     JECFA (Joint FAO/WHO Expert Committee on Food Additives). Steviol glycosides. In: Compendium of Food Addditive Specifiations, 73th Meeting. FAO JECFA monographs 10; 2010:17−22.
11.     Chatsudthipong V, Muanprasat C. Stevioside and related compounds: Therapeutic benefits beyond sweetness. Pharmacol Ther. 2009;121(1):41-54. doi:10.1016/j.pharmthera.2008.09.007
12.     Martono Y, Riyanto S, Rohman A, Martono S. Improvement method of fast and isocratic RP-HPLC analysis of major diterpene glycoside from Stevia rebaudiana leaves. In: AIP Conference Proceedings. Vol 1755. ; 2016. doi:10.1063/1.4958509
13.     USP. Validation of compendial procedures. In: Usp. Vol <1225> USP. ; 2011:778-782.
14.     Chaturvedula VSP, Zamora J. Reversed-Phase HPLC Analysis of Steviol Glycosides Isolated from Stevia rebaudiana Bertoni. Food Nutr Sci. 2014;05(17):1711-1716. doi:10.4236/fns.2014.517184
15.     D. B. Jadhao SDK and BNT. Improved RP-HPLC Method for Quantitative Estimation of Stevioside in Stevia rebaudiana Bertoni Burm. iIternational J Phytopharm. 2011;1 (2), p.(October 2015):27-34. doi:10.7439/ijpp.v1i2.162
16.     Jaworska K, Krynitsky AJ, Rader JI. Simultaneous analysis of steviol and steviol glycosides by liquid chromatography with ultraviolet detection on a mixed-mode column: Application to stevia plant material and stevia-containing dietary supplements. J AOAC Int. 2012;95(6):1588-1596. doi:10.5740/jaoacint.11-435
17.     Woelwer-Rieck U, Lankes C, Wawrzun A, Wüst M. Improved HPLC method for the evaluation of the major steviol glycosides in leaves of Stevia rebaudiana. Eur Food Res Technol. 2010;231(4):581-588. doi:10.1007/s00217-010-1309-4
18.     Montoro P, Molfetta I, Maldini M, et al. Determination of six steviol glycosides of Stevia rebaudiana (Bertoni) from different geographical origin by LC-ESI-MS/MS. Food Chem. 2013;141(2):745-753. doi:10.1016/j.foodchem.2013.03.041
19.     Lorenzo C, Serrano-Díaz J, Plaza M, Quintanilla C, Alonso GL. Fast methodology of analysing major steviol glycosides from Stevia rebaudiana leaves. Food Chem. 2014;157:518-523. doi:10.1016/j.foodchem.2014.02.088
20.     Soufi S, D’Urso G, Pizza C, Rezgui S, Bettaieb T, Montoro P. Steviol glycosides targeted analysis in leaves of Stevia rebaudiana (Bertoni) from plants cultivated under chilling stress conditions. Food Chem. 2016;190:572-580. doi:10.1016/j.foodchem.2015.05.116
21.     Gardana C, Simonetti P. Determination of steviol glycosides in commercial extracts of Stevia rebaudiana and sweeteners by ultra-high performance liquid chromatography Orbitrap mass spectrometry. J Chromatogr A. 2018;1578:8-14. doi:10.1016/j.chroma.2018.09.057
22.     Ahmad S, Chester K, Tamboli E, Singh M. Simultaneous quantification of stevioside and rebaudioside A in different stevia samples collected from the Indian subcontinent. J Pharm Bioallied Sci. 2012;4(4):276. doi:10.4103/0975-7406.103236
23.     Saifi M, Ali A, Nasrullah N, Khan S. A rapid and efficient high performance thin layer chromatographic ( HPTLC ) method for simultaneous analysis of stevioside and rebaudioside-a in Stevia Rebaudiana Innovare. Int J Pharm Pharm Sci. 2014;6(June):455-462.
24.     Nanaware SVL and SM. HPTLC Method for Simultaneous Analysis of Stevioside and. J AOA C Int. 2013;96(15). doi:10.5740/jaoacint.11-257
25.     Martono Y, Trihandaru S, Rondonuwu FS. Determination of Stevioside and Rebaudioside A in Stevia rebaudiana Bertoni Leaves Using near Infrared Spectroscopy and Multivariate Data Analysis. 2018;18(4):664-671. doi:10.22146/ijc.25580
26.     Martono Y, Rohman A. Quantitative Analysis Of Stevioside and Rebaudioside A in Stevia Rebaudiana Leaves Using Infrared Spectroscopy and Multivariate Calibration. Int J Appl Pharm. 2019;11(1):38-42.
27.     Udompaisarn S, Arthan D, Somana J. Development and Validation of an Enzymatic Method To Determine Stevioside Content from Stevia rebaudiana. J Agric Food Chem. 2017;65:3223-3229. doi:10.1021/acs.jafc.6b05793
28.     Molina-Calle M, Sánchez De Medina V, Delgado De La Torre MP, Priego-Capote F, Luque De Castro MD. Development and application of a quantitative method based on LC-QqQ MS/MS for determination of steviol glycosides in Stevia leaves. Talanta. 2016;154:263-269. doi:10.1016/j.talanta.2016.03.051
29.     Ermer J. Analytical Validation within the Pharmaceutical Environment. In: Miller JE and JHM, ed. Method Validation in Pharmaceutycal Analysis. 1st ed. Wiley-VCH Verlag GmbH & Co.KGaA, Weinheim; 2005:15-19.

Recomonded Articles:

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Author(s): Vandana Gautam, Dhriti Kapoor, Saroj Arora, Renu Bhardwaj*

DOI: 10.5958/0974-360X.2016.00166.9         Access: Open Access Read More

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Author(s): Krishnendu Acharya*, Somanjana Khatua, Salman Sahid

DOI: Not Available         Access: Open Access Read More

Author(s): S. Poongothai, C.M. Karrunakaran, R. Ilavarasan

DOI: Not Available         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags