Author(s):
Hindustan Abdul Ahad, Tarun Ksheerasagare, Aravind Chelluru, Chinthaginjala Haranath, Gorantla Surya Prakash Reddy, Jyothi Vinay Krishna
Email(s):
abdulhindustan@gmail.com
DOI:
10.5958/0974-360X.2020.00958.0 
Address:
Hindustan Abdul Ahad, Tarun Ksheerasagare, Aravind Chelluru, Chinthaginjala Haranath, Gorantla Surya Prakash Reddy, Jyothi Vinay Krishna
Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, Ananthapuramu – 515721, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 11,
Year - 2020
ABSTRACT:
The craving for better delectableness in oral dosage forms makes in the emerging of a wide range of formulations with enhanced enactment and adequacy. Orally disintegrating tablets (ODT) are an incipient movement in novel drug delivery systems and gaining attraction in the market and patients. ODTs, which hastily disintegrates or dissolves in the oral cavity deprived of water. Numerous newer agents have been established as superdisintegrants viz., synthetic, semi-synthetic and natural have been engaged in creating efficient ODT. The authors in this article aimed to acme the different superdisintegrants emerged from nature and successfully tried as their properties. The authors reviewed innumerable literature from reputed journals and made a list of natural superdisintegrants tried which will be helping the researchers as a quick reference for their study.
Cite this article:
Hindustan Abdul Ahad, Tarun Ksheerasagare, Aravind Chelluru, Chinthaginjala Haranath, Gorantla Surya Prakash Reddy, Jyothi Vinay Krishna. Herbal Mucilage attempted as a Super disintegrating agent in Oral Disintegrating Tablets. Research J. Pharm. and Tech. 2020; 13(11):5489-5492. doi: 10.5958/0974-360X.2020.00958.0
Cite(Electronic):
Hindustan Abdul Ahad, Tarun Ksheerasagare, Aravind Chelluru, Chinthaginjala Haranath, Gorantla Surya Prakash Reddy, Jyothi Vinay Krishna. Herbal Mucilage attempted as a Super disintegrating agent in Oral Disintegrating Tablets. Research J. Pharm. and Tech. 2020; 13(11):5489-5492. doi: 10.5958/0974-360X.2020.00958.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-11-73
REFERENCES:
1. Raghu U, Ahad HA, Satish P, Siddeshwara S, Dhanalakshmi AC, Tejeshwini H. A quick reference to plant gums and mucilages used as a tablet binder. Int J Pharm Sci Res. 2018; 3 (12): 207-2010.
2. Ahad HA, Kumar CS, Kumar BA, Reddy BA, Shekar AC, Sagar NR. Permeation studies of diclofenac sodium from Ficus carica fruit mucilage matrices for transdermal delivery. Int J Chem Tech Res. 2010; 2(2):937-41.
3. Hindustan AH, Yesupadam P, Ramyasree P, Suma Padmaja B, Sravanthi M, Guru Prakash P. Isolation and physicochemical characterization of Hibiscus rosa-sinensis leaves mucilage. Int J current res. 2011; 3(4):210-2.
4. Alam MT, Parvez N, Sharma PK. FDA-Approved natural polymers for fast dissolving tablets. Journal of pharmaceutics. 2014.
5. Singh P, Mahmood T, Shameem A, Bagga P, Ahmad N. A review on Herbal Excipients and their pharmaceutical applications. Sch Acad J Pharm. 2016; 5(3):53-7.
6. Stevanovic ZD, Stankovic MS, Stankovic J, Janackovic P, Stankovic M. 21 Use of Halophytes as Medicinal Plants: Phytochemical Diversity and Biological Activity. Halophytes and Climate Change: Adaptive Mechanisms and Potential Uses. 2019 Feb 14:343.
7. Lakshmi MP, Shailaja P, Jagan NV, Narendra D. Isolation, Purification of Carica Papaya And Ocimum Basilicum Seed Mucilages and Preparation of Valsartan Oro Dispersable Tablets By Using Natural Superdisintegrants. Int J of Sci Dev and Res. 2019; 4(1), 41-48.
8. Sandeep D, Vidyadhara S, Chirudeep J, Formulation and evaluation of febuxostat fast dissolving tablets using Entada scandens seed starch and poloxamer-188 as superdisintegrants, Int J Applied Pharmaceutics, 2019; 11 (5): 241-250.
9. Sundeep M, Vidyadhara S, Sandeep D, Sasidhar RLC, Ramu A, Siva PS. Formulation and evaluation of Telmisartan Fast Dissolving tablets Using Jack Fruit Seed Starch as Superdisintegrant, Int J App Pharmaceutics. 2019; 11 (5): 25-32.
10. Sharma AK, Sharma V, Soni SL, Pareek R, Goyal RK, Khandelwal M. Formulation and evaluation of fast dissolving tablet of domperidone using fenugreek seed mucilage as natural superdisintegrant by direct compression method. World J Pharmacy and Pharm Sci. 2018; 7(2): 643-653.
11. Njoroge A.N., Tirop L.J., Evaluating Corchorus olitorius plant mucilage in the formulation of oro-dispersible paediatric sildenafil tablets, Pharm J Kenya, 2018; 23 (4): 122-126.
12. Taymouri S, Mostafavi SA, Yazdankhah S. Preparation and Physicochemical Evaluation of Oral Disintegrated Tablet Containing Dicyclomine Hydrochloride. J Reports in Pharm Sci. 2018; 7(2):164.
13. Mannem Venkatarao, Vidyadhara S. Formulation and Evaluation of Atorvastatin Fast Dissolving Tablets using Entada scandens Seed Starch as Superdisintegrant. Asian J Pharm. 2018; 12(03).
14. Rita NW, Chetan MC. Development of orodispersible tablet using lepidium sativum seed mucilage as natural super disintegrant, Int J of Chem Tech Res. 2017; 10 (6): 605-616.
15. Bucktowar K, Bucktowar S, Bucktowar M, Bholoa LD, Ganesh NS. Formulation and Evaluation of Fast Dissolving Tablets of Paracetamol using Ocimum basilicum Seed Mucilage as Superdisintegrant. Int Res J of Pharm and Bio. 2017. 4 (1) 44.
16. Vinay PK, Sushma G, Ganesh KG. The effect of superdisintegrants on the dissolution of atenolol fast dissolving tablets, Int. J. of Pharmacy and Analytical Research. 2017; 6(4): 654-659.
17. Mohammed S, Sharma SK, Kaucha K, Hiremath D. Formulation and evaluation of flurbiprofen fast disintegrating tablets using natural superdisintegrants. Asian J Pharm Clin Res. 2016; 9(6):247-54.
18. Bandi B, Prathyusha A, Uma MV. Formulation design and invitro evalution of oral dispersible tablets of drugs using okra mucliage as taste masking agent, IJIPSR. 2015; 3 (5), 605-617.
19. Sai PB, Syamala S, Vinod KN, Voleti VK, Madhusudhan CC. Formulation and evaluation of orodispersible tablets of clonazepam using natural superdisintegrants, J Pharm Bio Sci. 2014; 9 (4): 47-52.
20. Tabbakhian M, Shahtalebi MA, Salehi E, Keshvari M. Formulation and evaluation of orally disintegrating tablet of Rizatriptan using natural superdisintegrant. J Herb Med Pharmacol. 2014; 3(1): 21-29.
21. Neha K, Manju N, Loveleen K, Gitika AD, Rajni B. Fast Dissolving Tablets of Domperidone Using Natural Superdisintegrant: Formulation and Optimization, Res J Pharm Biological and Chemical Sci. 2014; 5(1): 914-930.
22. Neeharika V. Comparative evaluation of natural and synthetic superdisintegrants in the formulation of fast dissolving tablets. Turk J Pharm Sci. 2013; 10(3):351-66.
23. Kishore VS, Rao BT, Pavani K, Nagasen D, Varma KR, Gowtham D. Plantago ovata seeds and bhringaraj leaves as superdisintegrants: formulation and evaluation of sotalol hydrochloride orodispersible tablets. International Journal of Pharmaceutical, Chemical and Biological Sciences. 2013; 3(4).
24. Lavande JP, Ade RN, Jaiswal SB, Chandewar AV. Evaluation and optimization of Olmesartan medoxomil tablet using synthetic and natural superdisintegrants. Int. J. Pure App. Biosci. 2013; 1(5):19-29.
25. Saini P, Sharma N. Natural polymers used in fast disintegrating tablets: A review. International journal of drug development and research. 2012; 4:18.
26. Kamble MS, Mendake SD, Aute PP, Mane SS, Borwandkar VG, Mane OR, Chaudhari PD. Pharmaceutical Characterization of ocimum tenuiflorum Linn. Seed mucilage as superdisintegrant. Int J of Pharm and Chem Sci. 2012; 1(4):1640-5.
27. Patel TK, Patel AK, Patel VM. Comparative study on effect of Natural and Synthetic super Disintegrants in the formulation of Carbamazepine Fast Dissolving Tablets. JPSBR-2011; 2(1), 11-17.
28. Anusha P, Basavaraj B, Bharath S, Deveswaran R, Madhavan V. Formulation and evaluation of ciprofloxacin dispersible tablets using plantago ovata mucilage in comparison with other superdisintegrants. Int. J. Chem. Sci. 2011; 9(2), 664-672.
29. Patil B, Rao N. Formulation and evaluation of fast dissolving tablets of candesartan cilexetil using natural and synthetic superdisintegrants. J Appl Pharm. 2011; 3 (3):250-61.
30. Jyothi G, Lakshmi PK. Comparative evaluation of natural and synthetic superdisintegrants with newer superdisintegrant Kyron T-314. Acta Pharmaceutica Sciencia. 2011; 53(1).
31. Sachan AK. Comparative Study of Natural and Synthetic Superdisintegrants in Orodispersible Metformin Tablet. Asian J of Pharm Res Dev. 2019; 7(3):46-53.
32. Mona P, Rohini D, Prabhakar BD, Rakesh P. Studies on Orally Disintegrating Tablets Prepared by Using Natural and Synthetic Superdisintegrants. International Journal of Drug Delivery Technology. 2018 Nov 2; 8(2):60-6.
33. Shirsand SB, Suresh S, Para MS, Swamy PV, Kumar DN. Plantago ovata mucilage in the design of fast disintegrating tablets. Ind j of pharm sci. 2009; 71(1):41.
34. Kaur L, Bala R, Kanojia N, Nagpal M, Dhingra GA. Formulation development and optimization of fast dissolving tablets of aceclofenac using natural superdisintegrant. ISRN pharmaceutics. 2014 May 8.
35. Sachan AK. Comparative Study of Natural and Synthetic Superdisintegrants in Orodispersible Metformin Tablet. Asian J of Pharm Res Dev. 2019; 7(3):46-53.
36. Indrajeet SP, Omkar AP, Vishal VB. Formulation and Evaluation of Orodispersible Tablets of Clopidogrel Bisulfate Using Natural Superdisintegrants, Indian Journal of Novel Drug Delivery, 2018; 10(1), 17-23.
37. Gharge VG, Ghorpade PU, Sakhare SS, Patil AA, Yadav AV. Comparative evaluation of disitegtrant properties in nimesulide tablet formulation by using natural and synthetic superdisintegrant, Int J Res Pharm Nano Sciences, 2017; 6(1): 1-9.
38. Patel M, Patel V, Surti N, Patel K. Formulation and Evaluation of Lorazepam Fast Dissolving Tablets using Synthetic and Natural Disintegrants, Res J Recent Sci. 2015; 4: 185-191.
39. Asha LM, Padavala S, Bhargavi CH. Formulation and evaluation of fast dissolving tablets of Telmisartan using Natural Superdisintegrants. Int jou of inn drug discovery. 2015; 5(1):25-9.
40. Arun R. Comparative evaluation of potato starch and banana powder as disintegrating agents in aceclofenac tablet formulation. Int J Pharm Sci. 2013; 5, 204-7.
41. Panigrahi R, Chowdary KA, Mishra G, Bhowmik M, Behera S. Formulation of fast dissolving tablets of Lisinopril using combination of synthetic superdisintegrants. A J of Phar and Tech. 2012; 2(3), 94-8.
42. Sukhavasi S, Kishore VS. Formulation and evaluation of fast dissolving tablets of amlodipine besylate by using Fenugreek seed mucilage and Ocimum basilicum gum. Int Current Pharm J. 2012; 1(9):243-249.
43. Napa LP, Gopinath S, Shanmuganathan S, Thameemul AH. Comparative study of natural super disintegrants on the formulation development of oromelts containing bromhexine hydrochloride, World J Pharm Res. 2016, 5 (6), 1326-1338.
44. Muralidhar P, Bhargav E, Nagendra P. Comparative study of natural superdisintegrating agents in the formulation of rosuvastatin mouth dissolving tablets. Int Res J of Pharm, 2016; 7(9):19-25.