Author(s): I Putu Sudayasa, Adryan Fristiohady, Wahyuni, Baru Sadarun, Mentarry Bafadal, La Ode Muhammad Julian Purnama, Nur Syifa Rahmatika, Wa Ode Indri Lestari Kalimin, I. Sahidin

Email(s): sahidin02@uho.ac.id

DOI: 10.5958/0974-360X.2020.00952.X   

Address: I Putu Sudayasa1, Adryan Fristiohady2, Wahyuni2, Baru Sadarun3, Mentarry Bafadal2, La Ode Muhammad Julian Purnama2, Nur Syifa Rahmatika1, Wa Ode Indri Lestari Kalimin1, I. Sahidin2*
1Faculty of Medicine, Universitas Halu Oleo, Kendari 93232 Southeast Sulawesi, Indonesia.
2Faculty of Pharmacy, Universitas Halu Oleo, Kendari 93232 Southeast Sulawesi, Indonesia.
3Faculty of Fisheries and Marine Sciences, Universitas Halu Oleo, Kendari 93232 Southeast Sulawesi, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
IL-1ß is one of the specific biological agents responsible for an inflammatory process. This study aims to investigate the effect of both extract Xestospongia sp. and Aaptos sp. in decreasing plasma IL-1ß level in the given time. Xestospongia sp. and Aaptos sp. were extracted by 96% ethanol. Each extract was then suspended into distilled water resulting in various concentrations (50; 100; and 200ppm). Rats were induced by 1% carrageenan intraplantar then were divided into groups (n = 5, each group). After being left for 1 hour, animals treated orally by Xestospongia sp. 50 ppm, 100ppm, and 200ppm; Aaptos sp. 50ppm; 100ppm; and 200ppm), vehicle 0.5% NaCMC (as negative control), and diclofenac sodium 3598 ppm (as positive control). Blood collection was conducted 2 and 3 hours post-treated, then were analyzed by using the ELISA kit. The result showed that Xestospongia sp. 100 and 200ppm and Aaptos sp. were decreasing plasma IL-1ß levels at 2 and 3-hour of measurement (p<0.05). In conclusion, both Xestopongia sp. and Aaptos sp. have biological activity as anti-inflammatory agents by decreasing plasma IL-1ß levels.


Cite this article:
I Putu Sudayasa, Adryan Fristiohady, Wahyuni, Baru Sadarun, Mentarry Bafadal, La Ode Muhammad Julian Purnama, Nur Syifa Rahmatika, Wa Ode Indri Lestari Kalimin, I. Sahidin. Effect of Extract Marine Sponge Xestospongia sp. and Aaptos sp. on the Plasma IL-1β Level in Inflammatory Model Rats: Time Dependent. Research J. Pharm. and Tech. 2020; 13(11):5455-5458. doi: 10.5958/0974-360X.2020.00952.X


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