Author(s): Kateryna Romas, Natalya Polovkо, Liliia Vyshnevskа, Olga Antonenko

Email(s): romas.k.1983@gmail.com

DOI: 10.5958/0974-360X.2020.00939.7   

Address: Kateryna Romas, Natalya Polovkо, Liliia Vyshnevskа, Olga Antonenko
National University of Pharmacy, Kharkiv, Ukraine.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
The objective of the work is to develop the composition and technology of granules based on arginine and ginseng. Methods. Physical, chemical and technological methods have been used. Results. After preliminary determination of L-Arginine properties, it was found that it has poor flowability. To improve technological properties, it was necessary to select an auxiliary substance. It was found that the most suitable excipient is lactose monohydrate. In order to avoid additional stages of the manufacturing process when tincture of ginseng roots was introduced into the mixture, it was decided to use it as a granulating liquid. Obtained granules showed the best result of flowability, but there was a pronounced heterogeneity in the shape and size of the granules. Necessary was the introduction of granulating liquid binders, as which 5 % alcohol solution of polyvinylpyrrolidone was chosen. In order to prevent excessive wetting of the mass as a solvent to obtain a 5 % solution of polyvinylpyrrolidone, we used ethanol 70 % and a tincture of the ginseng root. Obtained granules are grains of round, cylindrical and irregular shape, homogeneous in color, with a specific odor, sweet taste. Conclusions. Based on technological, physical and chemical researches we developed a rational technology of granules for the treatment of cerebrovascular diseases. Auxiliary substances and the granulation method were selected. Technological properties of granules were studied. Quality indicators were determined, expiration dates and conditions for their storage were set.


Cite this article:
Kateryna Romas, Natalya Polovkо, Liliia Vyshnevskа, Olga Antonenko. The Development of Granules Based on Arginine and Ginseng. Research J. Pharm. and Tech. 2020; 13(11):5370-5374. doi: 10.5958/0974-360X.2020.00939.7


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