Sara Jadda, Zakaria Abidli, Hinde Hami, Naima Rhalem, Houda Sefiani, Abdelmajid Soulaymani, Abdelrhani Mokhtari, Rachida Soulaymani-Bencheikh
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Sara Jadda1, Zakaria Abidli1, Hinde Hami1, Naima Rhalem2 Houda Sefiani2, Abdelmajid Soulaymani1, Abdelrhani Mokhtari1, Rachida Soulaymani-Bencheikh2,3
1PPR-B-Mokhtari-FS-UIT-Kenitra, Laboratory of Genetics and Biometry, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
2Anti Poison and Pharmacovigilance Center, Rabat, Morocco.
3Faculty of Medicine, Mohammed V University, Rabat, Morocco.
Volume - 13,
Issue - 11,
Year - 2020
Objective: the present study aims to desribe the characteristics of medication errors occuring in Moroccan children and to analyze the risk factors associated with the hospitalization of cases. Methods: This is a retrospective study of medication errors occurring in children under the age of 15 and declared via the telephone response to the toxicological information unit of the Anti Poison and Pharmacovigilance Center of Morocco during the period from the 1st January 2014 until December 31, 2017. Results: During the study period, 295 medication errors in children were reported to the Anti Poison and Pharmacovigilance Center of Morocco. The average age was 4.2±3.3 years with extremes ranging from 2 days to 14 years. In order to highlight the factors influencing the hospitalization of patients, we studied the effect of the following variables: dose error, drug error, posology error, error related to the patient’s entourage, error related to the patient, symptomatology. Among the 46 cases with known symptoms, 33 children presented hepato-digestive disorders. Medication errors due to patients represent 3.5 times the risk of hospitalization (RR=3.5; 95% CI : [6.5-37.9]), the same risk for symptomatic cases with (RR = 3.5; 95% CI: [12.4- 46.8], while the dose and administration errors represent respectively 1.4 (RR = 1.4; 95% CI: [33-70.7]) and 1.1 1 (RR = 1.1; 95% CI: [1.4-28.2]) of the hospitalization risk. Conclusion: Medication erros can cause very considerable damage, sometimes even resulting in the death of the child. For this, future research is needed to put in place effective prevention strategies that can reduce the risk of errors in children. However, awareness campaigns can also be useful for health professionals and the general public.
Cite this article:
Sara Jadda, Zakaria Abidli, Hinde Hami, Naima Rhalem, Houda Sefiani, Abdelmajid Soulaymani, Abdelrhani Mokhtari, Rachida Soulaymani-Bencheikh. Epidemiology and Risk factors related to Medication errors in Moroccan children. Research J. Pharm. and Tech. 2020; 13(11):5355-5359. doi: 10.5958/0974-360X.2020.00936.1
1- Shaohan W. and Haikuan W. Medical Errors, Regrettable Mistakes in Public Health. Iranian Journal of Public Health. 2018; 47(7): 1052.
2- Annegret F. Medical Error Disclosure: A Pressing Agenda for Public Health Researcher. Journal of Public Health Research. 2012; 1(3) : 214-215.
3- Poole R. and Carleton B. Medication Errors: Neonates, Infants and Children Are the Most Vulnerable! The Journal of Pediatric Pharmacology and Therapeutics. 2008; 13(2) : 65-67.
4- Aronson J. Medication errors: what they are, how they happen, and how to avoid them ? International Journal of Medicine. 2009; 102(8) : 513-521.
5- Rishoej R. et al. Medication errors in pediatric inpatients: a study based on a national mandatory reporting system. Eur J Pediatr. 2017; 176(12) : 1697-1705.
6- Maaskant J. et al. Interventions for reducing medication errors in children in hospital. Cochane Database of Systematic Reviews. 2015.
7- Whittaker CF. et al. Medication Safety Principles and Practice in CKD. Clin J Am Soc Nephrol. 2018; 13(11) : 1738-1746.
8- Kaushal R. et al. Medication errors and adverse drug events in pediatric inpatients. JAMA. 2001; 285(16) : 2114-2120.
9- American Academy of Pediatrics. Every 8 minutes a child experiences an out-of-hospital medication error. Available from : URL : http://www.aap.org/en-us/about-the-aap/aap-press-room/Pages/Every-8-Minutes-a-Child-Experiences-an-.aspx.
10- Gouyon JB. et al. Medication errors in neonatal medicine: From prescription to administration. Archives de Pédiatrie. 2012; 19(9) : 976-983.
11- Bailey SC. et al. Predictors of misunderstanding pediatric liquid medication instructions. Fam Med. 2009; 41(10) : 715-721.
12- Amy W. Minimizing Medication Errors in Pediatric Patients. US Pharm. 2019; 44(4) : 20-23.
13- Zayyanu S. et al. Avoiding medication errors through effective communication in a healthcare environment. Malaysian Journal of Movement, Health & Exercise. 2018; 7(1) : 113-126.
14- Rinke M. et al. Interventions to Reduce Pediatric Medication Errors: A Systematic Review. Pediatrics. 2014; 134(2) : 338-360.
15- Achour S. et al., Child Medication Errors in Morocco. Clinical Toxicology. 2012; 50(4) : 310.
16- Manias E. et al. Medication errors in hospitalised children. Journal of Paediatrics and Child Health. 2014; 50(1) : 71-77.
17- Kozer E. Medication errors in children. Paediatr Drugs. 2009; 11(1) : 52-54.
18- Hirata KM. et al. Pediatric Weight Errors and Resultant Medication Dosing Errors in the Emergency Department. Pediatr Emerg Care. 2019; 35(9) : 637-642.
19- Dabliz R. and Levine S. Medication safety in neonates. Am J Perinatol. 2012; 29(1) : 49-56.
20- Lefebvre L. Intoxications par produits domestiques et médicaments chez l’enfant. Available from: URL: https://www.inspq.qc.ca/bise/intoxications-par-produits-domestiques-et-medicaments-chez-l-enfant.
21- Madhulika E. et al. Analgesic-Related Medication Errors Reported to US Poison Control Centers. Pain Medicine. 2018; 19(12): 2357–2370.
22- Neuspiel D. and Taylor M. Reducing the risk of harm from medication errors in children. Health Services Insights. 2013; 30(6) : 47-59.