Author(s): Sabarinath C, Nandhu T, Sudhakar P, Gayathiri N.M, Shanmuganath C

Email(s): revathi.sabari@gmail.com

DOI: 10.5958/0974-360X.2020.00929.4   

Address: Sabarinath C1*, Nandhu T1, Sudhakar P1, Gayathiri N.M1, Shanmuganath C2
1Department of Pharmacology, Swamy Vivekanandha College of Pharmacy, Tiruchengode – 637205, Namakkal DT, Tamilnadu, India.
2Veterinary Assistant Surgeon, Tamilnadu Animal Husbandry Department, Kovilpatti – 628502, Thoothukudi DT, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Zebrafish model produce hundreds of offspring at weekly intervals providing scientists with an ample supply of embryos to study. As zebrafish eggs are fertilised and develop outside the mother’s body it is an ideal model organism for studying early development. In our present investigation we carried out the teratogenic effect of ethanolic extract of Solanum xanthocarpum berries in zebrafish embryo. Teratology is the study of abnormal development in embryo and causes congenital malformation or birth defects. Solanum xanthocarpum berries were extracted and prepared the five different concentrations of the extract 10%, 5%, 1%, 0.5%, and 0.1% respectively. The embryo-toxic effects, hatchability, and morphological abnormalities of extract treated embryos were determined. Zebrafish embryos exposed to different concentrations of Solanum xanthocorpum extract was proven to have embryotoxic (lethal) and teratogenic effects.


Cite this article:
Sabarinath C, Nandhu T, Sudhakar P, Gayathiri N.M, Shanmuganath C. Teratogenic effect of Ethanolic extract of Solanum xanthocarpum berries in Zebrafish embryo. Research J. Pharm. and Tech. 2020; 13(11):5313-5316. doi: 10.5958/0974-360X.2020.00929.4


REFERENCES:
1.    A. Gurib-Fakim, Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine. 2006; 27(1): 1–93.
2.    Kumar R, Khan M, Prasad M, Badrudeen. Solasodine: A Perspective on their roles in  Health and Disease. Research Journal of Pharmacy and Technology.2019; 12(5): 2571-2576.
3.    Alves Pimenta S, Colaco B, Oliveria PA, Venancio C. Biological Concerns on the Selection of Animal Models for Teratogenic Testing. 2018; 1797:61-93.
4.    Benjamin Pina, Laia Navarro, Carlos Barata, Demetrio Raldua, Ruben Martinez, Marta Casado. Omics in Zebrafish Teratogenesis. 2018; 1797: 421-441.
5.    C.S. Martinez, D.A Feas et.al. In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae.2018; 66: 17-24.
6.    Sang Ho Kim, Chanchal Sharma et.al. Breeding of zebrafish in the laboratory environment for research development. Bangladesh Journal of Pharmacology. 2017; 12(4): 434-438.
7.    Cold Spring Harbor protocol.http://cshprotocols.cshlp.org/ content/2011/10/pdb.rec66449.full.
8.    Sabarinath C, Sudhakar P, Shanmuganath C. Phytochemical and Antibacterial screening on leaves of Solanum torvum. Asian Journal of Research in Pharmaceutical Sciences.2018; 8(3): 130-132.
9.    Cherry May R. Romagosa, Eden S. David, and Rich Milton R. Dulay. Embryo-toxic and teratogenic effects of Tinospora cordifolia leaves and bark extracts in Zebrafish (Danio rerio) embryos. Pelagia Research Library. 2016; 6(2):37-41.
10.    Camille Roxanne S. David, Angelica Angeles et.al. Moringa oleifera (Malunggay) Water Extracts Exhibit Embryo-toxic and Teratogenic Activity in Zebrafish (Danio rerio) Embryo Model. Scholars Research Library. 2016; 8 (7):163-168.

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