Author(s): Bipul Nath, Balen Saharia

Email(s): bipulnath@gmail.com

DOI: 10.5958/0974-360X.2020.00926.9   

Address: Bipul Nath1*, Balen Saharia2
1Royal School of Pharmacy, Assam Royal Global University, Betkuchi, Guwahati-781035, Kamrup, Assam, India.
2Godrej Consumer and Products Limited, Guwahati, Assam.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
The objective of the present investigation is to detect interaction of Vanlafaxine HCl (VNF) and HPMC in combination with ionic polymers sodium alginate for extended release (ER) purpose by DSC and FT-IR method. In the first phase of the study, differential scanning calorimeter (DSC) was used as tool to detect any interaction. In the next phase, excipients defined in the prototype formula were tested for their compatibility with VNF using FT-IR. In this study it was possible to observe the interactions of the VNF with magnesium stearate and lactose. In brief, tablets of VNF having an average weight of 200mg were prepared using varying quantity of HPMC K4M and release studies were carried out in phosphate pH 7.4 for a period of 12 hour to achieve extended release pattern. The tablets were also evaluated for physical properties, kinetic studies and stability studies. FTIR and DSC studies shown there was no interaction between drug, HPMC K4M and other filler excipients. The physical properties of tablets were found within the limits. Formulation F-5 having a composition of 20.0% w/w HPMC K4M and 10% sodium alginate exhibit predetermine drug release up to 12 hours following diffusion controlled swelling and slow erosion. The optimized formulations were subjected to stability studies and shown there were no significant changes in hardness, drug content and in-vitro drug release behaviours. Results of the present study indicated the suitability of the HPMC K4M hydrophilic matrix polymers in the preparation of extended release formulation of VNF.


Cite this article:
Bipul Nath, Balen Saharia. Studies on solid state compatibility of Vanlafaxine HCl with combination of HPMC and ionic polymers for extended release delivery. Research J. Pharm. and Tech. 2020; 13(11):5293-5300. doi: 10.5958/0974-360X.2020.00926.9


REFERENCE:
1.    Sastry SV, Nyshdham JR, Fix JA. Recent technological advances in oral drug delivery: A review. Pharm Sci Technol Today. 2000; 3: 138-145.
2.    Majeti N, Ravi K, Neeraj K. Polymeric controlled drug-delivery systems perspective issues and opportunities. Drug Dev Ind Pharm. 2001; 27: 1-30.
3.    Thumma S, Repka MA. Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. Pharmazie. 2009; 64: 183-9.
4.    Crowley P, Martini L. Drug-excipient interactions. Pharm Technol. 2001; 13: 26–34.
5.    McDaid FM, Barker SA, Fitzpatrick S, Petts CR, Craig DQM. Further investigations into the use of high sensitivity differential scanning calorimetry as a means of predicting drug-excipient interactions. Int J Pharm. 2003; 252: 235–40.
6.    Kiss D, Zelko R, Novak CS. Application of DSC and NIRs to study the compatibility of metronidazole with different pharmaceutical excipients. J Ther Ana Calor. 2006; 84: 447–51.
7.    Hawida KI, Salwa S. Formulation of venlafaxine for once daily administration using polymeric material hybrids. J Microencap. 2016; 33 (4): 299-306.
8.    Munira MM, Snehal K, Puja A. Formulation and evaluation of bilayer tablet for bimodal release of venlafaxine hydrochloride. Front Pharmacol. 2015; 6: 144-50.
9.    Shah RB, Tawakkul AK, Khan MA. Comparative Evaluation of Flow for Pharmaceutical Powders and Granules. AAPS Pharm SciTech. 2008; 9: 250-258.
10.    Ravi PR, Ganga S, Saha RN. Design and study of Lamivudine Oral Controlled Release Tablets. AAPS Pharm Sci Tech. 2007; 8: 1-9.
11.    Sampath KP, Debjit B, Chiranjib MC, Tripathi KK. Innovations in sustained release drug delivery system and its market opportunities. J Chem Pharm Res. 2010; 2 (1): 349-360.
12.    Defang O, Shufang N, Wei Y. In-vitro/in-vivo evaluation of two extended release preparations of combination metformin and glipizide. Drug Dev Ind Pharm. 2005; 31: 677- 685.
13.    Ritu D, Rajat G, Harsha P, Pradeep P, Bharat D. Formulation and Characterization of Sustained Release Matrix Tablet of Metformin Hydrochloride. Int J Pharm Recen Res. 2009; 1: 49-53.
14.    Yan G, Li H, Zhang R, Ding D. Preparation and evaluation of a sustained release formulation of Nifedipine HPMC tablets. Drug Dev Ind Pharm. 2000; 26: 681-686.
15.    Vidyadhara S, Prasad J. Formulation and evaluation of Propranolol hydrochloride oral controlled release matrix tablets. Ind J Pharm Sci. 2004; 66: 188-192.
16.    Mohd A, Hadi V, Lokeswara B, Narottam P. Formulation and Evaluation of Sustained Release Matrix Tablets of Glimepiride Based on Combination of Hydrophilic and Hydrophobic Polymers. J App Pharm Sci. 2012; 02 (6): 101-107.
17.    Moore JW, Flanner HH. Mathematical Comparison of Dissolution Profiles. Pharm Technol. 1996; 20: 64-74.
18.    Cartensen JT, Rhodes CT. Drug stability, principles and practices of pharmaceuticals. New York: Informa Healthcare; 2010, 358–365.
19.    Maderuelo C, Zarzuelo A, Lanao JM. Critical factors in the release of drugs from sustained release hydrophilic matrices. J Control Release. 2011; 154(1): 2-19.
20.    Wan Lucy SC, Heng Paul WS, Wong LF. Relationship between swelling and drug release in a hydrophilic matrix. Drug Dev Ind Pharm. 1993; 19(10): 1201-10.
21.    Liew CV, Lai WC, Ling C, Paul WS. Evaluation of sodium alginate as drug release modifier in matrix tablets Int J Pharm. 2006; 309 (1-2): 25-37.
22.    Li Li, Huijuan Sun, Jing Gao, Tao Jiang, Yuan Gao, Jianjun Zhang. Optimization of sustained release matrix tablet of metoprolol succinate using central composite design Pak. J Pharm Sci. September 2013; 26(5): 929-37.

Recomonded Articles:

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Priya P. Munshi, D.S. Mohale, R. Akkalwar, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Katare Varsha B., Bhutkar M. A., Kumbhar A. P., Pol S. K., Katare P. B.

DOI: Not Available         Access: Open Access Read More

Author(s): Kumkum Sarangdevot, Bhawani Singh Sonigara, Amul Mishra, K. C. Gupta, Surbhi Sharma

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Homendra Kumar Sahu, Kamdev Sen, Raju Patel, Hulash Sahu, Deepika Sahu, Gulshan Sahu, Chandrashekhar Jain, Narayan Prasad Chandra, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00173.1         Access: Open Access Read More

Author(s): S. Syed Shihaab E Noor, Pradeep

DOI: 10.5958/0974-360X.2016.00353.X         Access: Open Access Read More

Author(s): N. Chandarsekaran, M. Balamurugan

DOI: Not Available         Access: Open Access Read More

Author(s): Y. Prem Kumar, K. Vinod Kumar, V. Sai Kishore

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Ehtesham Ur Rahman, Mohammed Abdul Haseeb, Mohammed Saleem, Abdul Naveed

DOI: Not Available         Access: Open Access Read More

Author(s): Gupalli Laxmi Narasimha, Dappu Jairam, Akkenapally Krishna, Mohammed Rehan Qureshi

DOI: 10.5958/0974-360X.2015.00025.6         Access: Open Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Jagdale Swati C., Hable Asawaree A., Kuchekar Bhanudas S., Chabukswar Aniruddha R.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags