Author(s): Shihas Azeez, Linu Mohan Panakkal, Saleel Salman Meenpidiyil, Nafiya Sulaiman

Email(s): shihasshanu@gmail.com

DOI: 10.5958/0974-360X.2020.00889.6   

Address: Shihas Azeez*, Linu Mohan Panakkal, Saleel Salman Meenpidiyil, Nafiya Sulaiman
Department of Pharmacy Practice, Al Shifa College Pharmacy, Perinthalmanna, Malappuram, Kerala, India – 679321.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Background: Antibiotics are the most important class of drugs for major advancement in medical treatment but the efficacy of these medication diminishes upon its extensive use. In children, antibiotic is the most immensely used medications, that can be a lifesaving treatment in certain bacterial infections. Inappropriate use of these medications in pediatric population may cause drug toxicity, adverse events, and drug resistance. Objectives: This study aims at analyzing the antibiotic use among pediatric population and to evaluate the impact of an intervention by clinical pharmacist in minimizing inappropriate antibiotic use by creating awareness among both patient bystanders and physician. Methodology: A one-year prospective interventional research was performed in a 750 bedded hospital of south India. 180 subjects were randomly enrolled from the pediatric inpatients of the hospital and all relevant information were obtained from their case file and analyzed for irrational antibiotic use, and also a questionnaire was circulated among patient’s bystanders to assess their knowledge about antibiotics. Several strategies were developed and implemented through leaflets to reduce the inappropriate antibiotic use. Audits were conducted to assess the acceptance of strategies and to find out the impact of clinical pharmacist intervention. Results: Data were collected from 180 patient’s and in that male subjects were dominant (n= 108, 60%) from that of females (n= 72, 40%). In this study beta-lactam antibiotic (35.21%) are predominantly used in pediatrics and were most commonly prescribed for the treatment of respiratory tract infection (33.33%). In pre-intervention phase, inappropriate use of antibiotic was most commonly observed with wrong drug choice (23.3%) and poor knowledge on antibiotics, which was resolved to some extent with clinical pharmacist intervention in the post-intervention phase. Conclusion: Lack of knowledge was the prime reason irrational antibiotic use. Educational interventions and effective communication between healthcare professionals should be encouraged and physicians should adhere to antibiotic prescribing guidelines.


Cite this article:
Shihas Azeez, Linu Mohan Panakkal, Saleel Salman Meenpidiyil, Nafiya Sulaiman. Impact of Clinical Pharmacist Intervention in promoting Rational Antibiotic use in Pediatric patients. Research J. Pharm. and Tech. 2020; 13(11):5077-5082. doi: 10.5958/0974-360X.2020.00889.6


REFERENCES:
1.    Ceyhan M, Yildirim I, Ecevit C, Aydogan A, Ornek A, Salman N, Somer A, Hatipoglu N, Camcioglu Y, Alhan E, Celik U, Hacimustafaoglu M, Celebi S, Inan D, Kurt N, Oner AF, Gulumser O, Gunes A, Coskun Y. Inappropriate antimicrobial use in Turkish paediatric hospitals: A multicentre point prevalence survey. Int J Infectious Diseases 2010; e55: 14.
2.    Sreeja MK, Gowrishankar NL, Adisha S, Divya KC. Antibiotic resistance- reasons and the most common resistance pathogens- a review. Research J. Pharm. and Tech. 2017; 10(6): 1886-1890.   
3.     Desai SM, Undale VR. Antibiotic overuse and resistance: an awareness study. Research J. Pharm. and Tech. 2019; 12(6): 2794-2798.
4.    Maria JD, Aanandhi VM. An overview on antibiotic use and resistance. Research J. Pharm. and Tech. 2017; 10(8): 2793-2796.
5.    Ramalingam AJ. History of antibiotics and evolution of resistance. Research J. Pharm. and Tech. 2015; 8(12): 1719-1724.
6.    Laxminarayan R, Duse A, Wattal C, Zaidi AKM, Wertheim HFL, Sumpradit N, Vlieghe E, Hara GL, Gould IM, Gossens H, Greko C, So AD, Bigdeli M, Tomson G, Woodhouse W, Ombaka E, Peralta AQ, Qamar FN, Mir F, Kariuki S, Bhutta ZA, Coates A, Bergstorm R, Wright GD, Brown ED, Cars O. Antibiotic resistance- the need for global solutions. The Lancet Infectious Diseases 2013; 13(12): 1057-1098.
7.    Bharathiraja R, Sridharan S, Chelliah LR, Suresh S, Senguttuvan M. Factors affecting antibiotic prescribing pattern in pediatric practice. Indian J Pediatr 2005; 72: 877-879.
8.    Cosgrove SE. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stays, and health care costs. Clinical Infectious Diseases 2006; 42(2): 82-89.
9.    Acer JF. Consequences of bacterial resistance to antibiotics in medical practice. Clinical Infectious Diseases 1997; 24(1): 17-18.
10.    Thomson WM, Sudha M, Venkateshwaramurthy, Kumar RS. A review on the irrational antibiotic’s usage in pediatrics for respiratory tract infection. Research J. Pharm. and Tech. 2019; 12(10): 5126-5130.
11.    Mahashwar P, Manimekalai P, Anuja P, Biar A. Antibiotic drug utilization and evaluation in pediatric patients. Research J. Pharm. and Tech. 2017; 10(8): 2704-2706.
12.    Ramya A, Geetha P, Shanmughsundaram P. Assessment of appropriate use of antibiotics in paediatric department of a tertiary care teaching hospital. Research J. Pharm. and Tech. 2017; 10(2): 381-384.
13.    Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nature Medicine 2004; 10(12): 122.
14.    Lee CR, Cho H, Jeong BC, Lee SH. Strategies to minimize antibiotic resistance. Int J Environ Res Public Health 2013; 10: 4274-4305.
15.    Baquero F, Negri MC. Strategies to minimize the development of antibiotic resistance. J Chemother 1997; 9: 29-37.
16.    Reddy SN, Manohar B, Bhavani DM, Kejiya G, Sreevidya C, Ranganayakulu D. Prescribing pattern of drugs in pediatric wards at a tertiary care teaching hospital. Int J Pharm Rev Res 2015; 5(4): 374-378.
17.    Mezgebe HB, Tadesse B, Legesse B. Antibiotics prescribing pattern in pediatric unit of Ayder referral hospital, Tigray region, northern Ethiopia. J Sci Innov Res 2015; 4(2): 57-60.
18.    Kourlaba G, Gkrani-Klotsas E, Kourkouni E, Mavrogeorgos G, Zaoutis TE. Antibiotic prescribing and expenditures in outpatient pediatrics in Greece 2010–13: evidence from real-world practice. Euro Surveill. 2016; 21 (26): 30266.
19.    Ivanovska V, Hek K, Teeuwisse AKM, Leufkens HGM, Nielen MMJ, Dijk LV. Antibiotic prescribing for children in primary care and adherence to treatment guidelines. J Antimicrob Chemother 2016; 71(6): 1707-1714.
20.    Shidiki A, Pandit B, Vyas A. Incidence and antibiotic profile of bacterial isolates from neonatal septicemia in National Medical College and teaching hospital, Birgunj, Nepal. Research J. Pharm. and Tech. 2018; 11(6): 2238-2242.
21.    Shafinaz, Joel JJ, Bhat VS, Angel Rose ER. Study on drug utilization pattern of antibiotics in Respiratory Tract Infections. Research J. Pharm. and Tech. 2019; 12(3): 1189-1192.
22.    Pranay W, Ankita W, Rishabh S, Prateek R, Rai AK. Antibiotic therapy in pediatric patients. Research J. Pharm. and Tech. 2010; 3(2): 118-120.
23.    Mukherjee S, Sen S, Era N, Biswas A, Datta K, Tripathi SK. Antibiotic usage pattern among inpatients of a pediatric ward in a tertiary care hospital in eastern India, Int J Res Med Sci 2015; 3(12): 3681-3686.
24.    Spoorenberg V, Hulscher MEJL, Akkermans RP, Prins JM, and Geerlings SE. Appropriate antibiotic use for patients with urinary tract infections reduces length of hospital stay. J Clin Infect Dis 2014; 58(2):164–169.
25.    Thomas M, Govil S, Moses BV, Joseph A. Monitoring of antibiotic use in a primary and a tertiary care hospital. J Clin Epidemiol 1996; 49(2): 251-254.
26.    Ali SR, Ahmed S, and Lohana H. Trends of empiric antibiotic usage in a secondary care hospital, Karachi, Pakistan. Int J Pediatr 2013; 3: 235-239.
27.    Ibrahim OHM, El-Sharif S. The impact of clinical pharmacist interventions on drug and antibiotic prescribing in a teaching hospital in Cairo. Int J Pharm Pharmcol 2012; 3: 458-461.
28.    Bhullar HS, Shaikh FA, Deepak R, Poddutoor PK, Chirla D. Antimicrobial justification form for restricting antibiotic use in a pediatric intensive care unit. J Indian Pediatr 2016; 53: 304-306.
29.    Marc C, Vrignaud B, Levieux K, Robine A, Guen CGL, Launay E. Inappropriate prescription of antibiotics in pediatric practice: Analysis of the prescriptions in primary care. J Child Health Care 2016; 20(4): 530–536.
30.    Baktygul K, Marat B, Ashirali Z, Rashid HO, Sakamoto J. An assessment of antibiotics prescribed at the secondary health-care level in the Kyrgyz Republic, Nagoya. J Med Sci 2011; 73: 157-168.
31.    Pavydė E, Veikutis V, Mačiulienė A, Mačiulis V, Petrikonis K, Stankevičius E. Public knowledge, beliefs and behavior on antibiotic use and self-medication in Lithuania. Int J Environ Res Public Health 2015; 12: 7002-7016.

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