Author(s): Hardevinder Pal Singh, Thakur Gurjeet Singh, Randhir Singh

Email(s): gurjeet.singh@chitkara.edu.in , gurjeetthakur@gmail.com

DOI: 10.5958/0974-360X.2020.00922.1   

Address: Hardevinder Pal Singh1,2, Thakur Gurjeet Singh1, Randhir Singh3
1Chitkara College of Pharmacy, Chitkara University, Punjab, India.
2Department of Pharmacy, Government Medical College, Patiala, Punjab, India.
3MM College of Pharmacy, Maharishi Markandeshwar University, Mullana, (Ambala) Haryana, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
The objective of this study was to examine the role of peroxisome proliferator-activated receptor-gamma (PPAR-?) in renal protection provided by p-Coumaric acid in cisplatin induced nephrotoxicity in male rats. Single dose of cisplatin 5mg/kg (i.p.) was used to induce nephrotoxicity on first day of the study. The nephrotoxicity was evaluated by quantifying serum creatinine, creatinine clearance, urea, uric acid, potassium, magnesium, microproteinuria, fractional excretion of sodium. Superoxide anion generation, thiobarbituric acid reactive substances, myeloperoxidase activity and reduced glutathione levels were measured to assess oxidative stress in renal tissues whereas; hematoxylin eosin stain demonstrated renal histological changes. The nephrotoxicity was confirmed by the elevated level of urinary and blood parameters, increased parameters of oxidative stress as well as from the histopathological studies of kidney. Different doses of p-Coumaric acid (50 and 100mg/kg, p.o.) significantly (p<0.05) attenuated the various parameters associated with the nephrotoxicity. Moreover, the effect was found to be dose dependent. The nephroprotective effect of p-Coumaric acid was abolished by BADGE (30mg/kg, i.p.), (a PPAR-? inhibitor) pretreatment in rats. It may be concluded that p-Coumaric acid produced nephroprotection via PPAR-? agonism.


Cite this article:
Hardevinder Pal Singh, Thakur Gurjeet Singh, Randhir Singh. Attenuation of Cisplatin–Induced Nephrotoxicity by p-Coumaric Acid through Peroxisome Proliferator-Activated Receptor-Gamma (PPAR-γ) Agonism in male Rats. Research J. Pharm. and Tech. 2020; 13(11):5270-5276. doi: 10.5958/0974-360X.2020.00922.1


REFERENCES:
1.    Ferguson MA, Vaidya VS, Bonventre JV. Biomarkers of nephrotoxic acute kidney injury. Toxicology. 2008; 245:182-93.
2.    Meher SK, Mukherjee PK, Chaudhury SK, Marjit B, Shaw BP. Experimental studies on the Renal Protective effect of Gokshura (Tribulus terrestris Linn) and Varuna (Crataeva nurvala Buch-Ham). Research Journal of Pharmacology and Pharmacodynamics. 2016; 8: 75-82.
3.    Izzedine H, Perazella MA. Anticancer drug-induced acute kidney injury. Kidney Int Rep. 2017; 2: 504-514.
4.    Abhirama BR, Shanmuga Sundaram Rajagopal, Mahadevan Nanjan. Nephroprotective effect of ethanol extract of Biophytum sensitivum (Linn.) DC in cisplatin-induced experimental renal damage in rats. Research J. Pharm. and Tech. 2017; 10: 1772-1779.
5.    Miller RP, Tadagavadi RK, Ramesh G, Reeves WB. Mechanisms of Cisplatin nephrotoxicity. Toxins (Basel). 2010; 2: 2490-518.
6.    Mugada V, Hanumanthu J, Shagufa J, Iype S, Yerlapati S. Assessment of Ototoxicity and Nephrotoxicity in patients receiving weekly Cisplatin Chemotherapy: A Prospective Observational Study. Research Journal of Pharmacy and Technology. 2019; 12: 1922-6.
7.    Arunkumar PA, Mukund H, Radheshyam N, Belliyappa MS. Clinical evaluation of cisplatin induced     nephrotoxicity characterized by electrolyte disturbances. Asian Journal of Research in Pharmaceutical Science. 2011;1: 100-4.
8.    Manohar S, Leung N. Cisplatin nephrotoxicity: a review of the literature. J Nephrol. 2018; 31: 15-25.
9.    Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: A review. Am J Med Sci. 2007; 334: 115-24.
10.    Wang X, Bonventre JV, Parrish AR. The aging kidney: increased susceptibility to nephrotoxicity. Int J Mol Sci. 2014; 15: 15358-76.
11.    Naughton C A. Drug-induced nephrotoxicity. Am. Fam. Physician. 2008; 78: 743-50.
12.    Jilanchi S, Talebi A, Nematbakhsh M. Cispaltin alters Sodium excretion and renal clearance in rats: Gender and Drug Dose Related. Adv Biomed Res. 2018; 7: 54.
13.    Philomena G. Concerns regarding the safety and toxicity of medicinal plants - An overview. J Appl Pharmaceut Sci. 2011; 1: 40-4 2.
14.    Yang B, Xie Y, Guo M, Rosner MH, Yang H, Ronco C. Nephrotoxicity and chinese herbal medicine. Clin J Am Soc Nephrol. 2018; 13: 1605-1611.
15.    Gerard D. Wright. Unlocking the potential of natural products in drug discovery. Microb Biotechnol. 2019; 12: 55–57.
16.    Peesa JP. Nephroprotective potential of herbal medicines: a review. Asian Journal of Pharmacy and     Technology. 2013; 3:115-8.
17.    Jaydeokar AV, Bandawane DD, Nipate SS, Chaudhari PD. Natural antioxidants: a review on therapeutic applications. Research Journal of Pharmacology and Pharmacodynamics. 2012;4(1):55-61.
18.    Akomolafe SF, Akinyemi AJ, Anadozie SO. Phenolic acids (gallic and tannic Acids) modulate antioxidant status and cisplatin induced nephrotoxicity in rats. Int Sch Res Notices. 2014; 2014: 984709.
19.    Kheirollahi A, Hasanvand A, Abbaszadeh S, Moghadasi M. Pathophysiology and Urinary System Cancer: An Overview of the most important Herbal Plants and Natural Antioxidants on Kidney and Bladder Disorders. Research Journal of Pharmacy and Technology. 2019; 12: 972-80.
20.    Sharma S, Rana M, Kumar H, Parashar B. It's era to move towards nature for getting beneficial effects of plants having Antioxidant activity to fight against deleterious diseases. Asian Journal of Pharmaceutical Research. 2013; 3: 103-6.
21.    Navaneethan D, Rasool M. p-Coumaric acid, a common dietary polyphenol, protects cadmium chloride-induced nephrotoxicity in rats. Ren Fail. 2014; 36: 244-51.
22.    Morton LW, Croft KD, Puddey IB, Byrne L Phenolic acids protect low density lipoproteins from peroxynitrite-mediated modification in vitro. Redox Rep. 2000; 5: 124–125.
23.    Luceri C, Guglielmi F, Lodovici M, Giannini L, Messerini L, Dolara P. Plant phenolic p-coumaric acid protects against intestinal inflammation in rats. Scand J Gastroenterol. 2004; 39: 1128–1133.
24.    Guan Y, Breyer MD. Peroxisome proliferator-activated receptors (PPARs): novel therapeutic targets in renal disease. Kidney Int. 2001; 60: 14-30.
25.    Zhou Y, Kong X, Zhao P, Yang H, Chen L, Miao J, Zhang X, Yang J, Ding J, Guan Y. Peroxisome proliferator-activated receptor-α is renoprotective in doxorubicin-induced glomerular injury. Kidney Int. 2011; 79: 1302-11.
26.    Kiss-Toth E, Roszer T. PPAR gamma in Kidney Physiology and Pathophysiology.     PPAR Res. 2008; 2008: 183108.
27.    Jesse CR, Bortolatto CF, Wilhelm EA, Roman SS, Prigol M, Nogueira CW. The peroxisome proliferator-activated receptor-γ agonist pioglitazone protects against cisplatin-induced renal damage in mice. J Appl Toxicol. 2014; 34: 25–32.
28.    Nematbakhsh M, Pezeshki Z, Jazi FE, Mazaheri B, Moeini M, Safari T, Azarkish F, Moslemi F, Maleki M, Rezaei A, Saberi S. Cisplatin-induced nephrotoxicity; protective supplements and gender differences. Asian Pac J Cancer Prev. 2017; 18: 295-314.
29.    Sehajpal J, Kaur T, Bhatti R, Singh AP. Role of progesterone in melatonin-mediated protection against acute kidney injury. J Surg Res. 2014; 191: 441-7.
30.    Kapil A, Singh JP, Kaur T, Singh B, Singh AP Involvement of peroxisome proliferator-activated receptor gamma in vitamin D-mediated protection against acute kidney injury in rats. J Surg Res. 2013; 185: 774-83.
31.    Singh R, Singh AP, Singh M, Krishan P. Impact of obesity on hypertension-induced cardiac remodeling: role of oxidative stress and its modulation by gemfibrozil treatment in rats. Free Radic Biol Med. 2011; 50: 363-70.
32.    Bradley PP, Priebat DA, Christensen RD, Rothstein G Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol. 1982; 78: 206-9.
33.    Sahu BD, Kalvala AK, Koneru M, Kumar JM, Kuncha M, Rachamalla SS, Sistla R. Ameliorative effect of fisetin on cisplatin-induced nephrotoxicity in rats via modulation of NF-κB activation and antioxidant defence. PloS one. 2014; 9: e105070.
34.    Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. J Agric Food     Chem. 2007; 55: 10150-5.
35.    Chirino YI, Pedraza-Chaverri J. Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity. Exp Toxicol Pathol. 2009; 61: 223-42.
36.    Michel HE, Menze ET. Tetramethylpyrazine guards against cisplatin-induced     nephrotoxicity in rats through inhibitingHMGB1/TLR4/NF-κB and activating Nrf2 and PPAR-γ signaling pathways. Eur J Pharmacol. 2019; 857: 172422.
37.    Ekinci Akdemir FN, Albayrak M, Calik M, Bayir Y, Gulcin I. The Protective Effects of p-Coumaric Acid on Acute Liver and Kidney Damages Induced by Cisplatin. Biomedicines. 2017; 28: E18.
38.    Ramesh G, Reeves WB. Salicylate reduces cisplatin nephrotoxicity by inhibition of tumor necrosis factor-alpha. Kidney Int. 2004; 65: 490-9.
39.    Zhao Y., Liu J., Liu C., Zeng X., Li X., Zhao J. Anti-inflammatory effects of p-coumaric acid in LPS-stimulated RAW264.7 cells: Involvement of NF-κB and MAPKs pathways. J. Med. Chem. 2016; 6: 327–330.
40.    Faubel S, Lewis EC, Reznikov L, Ljubanovic D, Hoke TS, Somerset H, et.al. Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and     neutrophil infiltration in the kidney. J Pharmacol Exp Ther. 2007; 322: 8-15.
41.    Singh AP, Singh AJ, Singh N. Pharmacological investigations of Punica granatum in glycerol–induced acute renal failure in rats. Indian J Pharmacol. 2011; 43: 551-6.
42.    Singh JP, Singh AP, Bhatti R. Explicit role of peroxisome proliferator-activated receptor gamma in gallic acid-mediatedprotection against ischemia-reperfusion-induced acute kidney injury in rats. J Surg     Res. 2014; 187: 631-9.
43.    Sivarajah A, Chatterjee PK, Patel NS, Todorovic Z, Hattori Y, Brown PA, Stewart KN, Mota-Filipe H, Cuzzocrea S, Thiemermann C. Agonists of peroxisome-proliferator activated receptor-gamma reduce renal ischemia/reperfusion injury. Am J Nephrol. 2003; 23: 267-76.
44.    Helmy MM, Helmy MW, El-Mas MM. Additive Renoprotection by Pioglitazone and Fenofibrate against Inflammatory, Oxidative and Apoptotic Manifestations of Cisplatin Nephrotoxicity: Modulation by PPARs. PLoS One. 2015; 10: e0142303.
45.    Abdel-Moneim A, El-Twab SMA, Yousef AI, Reheim ESA, Ashour MB. Modulation of     hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ. Biomed Pharmacother. 2018; 105: 1091-1097.
46.    Daynes, R.A., Jones, D.C. Emerging roles of PPARs in inflammation and immunity. Nat. Rev. Immunol. 2002; 2: 748.

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