Chilivari Alekhya, V. Alagarsamy
Chilivari Alekhya1*, V. Alagarsamy2
1Department of Pharmacology, MNR College of Pharmacy, Sangareddy, Telangana State, India.
2Department of Pharmaceutical Chemistry, MNR College of Pharmacy, Telangana State, India.
Volume - 13,
Issue - 11,
Year - 2020
Syzygium cumini (Family Myrtaceae) commonly named jamun, is one of the widely distributed medicinal plant in treating many diseases like diabetes, asthma, inflammation, etc. which is native to tropical America and Australia. The ethanolic extract of Syzygium cumini was investigated for anti inflammatory and anti asthmatic activity with their phytoconstituents in animal models. The extract has an anti-inflammatory effect demonstrated by its inhibitory effect in carrageenan induced paw edema. it also produced significant decrease in bronchoconstriction in histamine induced bronchoconstriction (in-vivo) and mast cell degradation method (in-vitro).
Cite this article:
Chilivari Alekhya, V. Alagarsamy. Anti-inflammatory and Anti-asthmatic activity of Ethanolic extract of Syzygium cumini plant bark. Research J. Pharm. and Tech. 2020; 13(11):5210-5214. doi: 10.5958/0974-360X.2020.00911.7
Chilivari Alekhya, V. Alagarsamy. Anti-inflammatory and Anti-asthmatic activity of Ethanolic extract of Syzygium cumini plant bark. Research J. Pharm. and Tech. 2020; 13(11):5210-5214. doi: 10.5958/0974-360X.2020.00911.7 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-11-26
1. Sosa S, Balick MJ, Arrigo R, Esposito RG, Pizza C, Altinier GA. Screening of the topical anti-inflammatory activity of some Central American plants. J Ethanopharmacol, 2002; 8: 211-215.
2. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma from bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med, 2000; 224-227.
3. Ament PW, Childers RS. Prophylaxis and treatment of NSAID- induced gastropathy. AM Fam Physician, 1997; 55: 1323-1331.
4. Elgorashi EE, Wada N, Warrag EI, Satoh H. Effect of Acacia species on adjuvant induced arthritis induced arthritis in rats. J Nat Rem, 2009; 9: 185-91.
5. Borgi W, Ghedira K, Chouchane N. Anti-inflammatory and analgesic activities of Zizyphus lotus root barks. Fitoterapia 2007, 78: 16-19.
6. Undem BJ. Pharmacotherapy of asthma. In: Brunton LL, Lazo JS, ParketKL, editors. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 11thedition New York: McGraw-h ill; 2006; 717-736.
7. Barnes PJ. Current therapies for asthma. Promise and limitations. Chest, 1997; 111: 17-26.
8. Patwardhan B, warude D, Pushpagadan Bhatt N. Ayurveda and traditional chinese medicine: A comparative overview. Evid Based Complement alternative Med, 2005; 2: 465-473.
9. Begovic S. Tannins as antagonist of vitamin B12 and natural regulators of Escherichia coli of the gastrointestinal tract of herbivorous animals. Veterinaria, - Yogoislavia 1978; 4:433-443.
10. Nakazato K, Takeo T. Anti-inflammatory effect of the oolong tea polyphenols. Nippon-Nogeikagaka- Kaishi, 1998; 72.
11. Harborne, J.B. and C.A. Williams. Advances in flavonoid research since 1992. Phytochemistry, 2000; 55: 481-504.
12. Ecobichon DJ. The basis of toxicology testing. RC press, New York, 1997, 43-86.
13. Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenan induced oedema in hind paw of rat as assay for anti-inflammatory drugs. Exp. Biol. Med., 111: 544-547.
14. Van Arman CG, Miller LM, O'Malley MP. SC-10049: A catecholamine bronchodilator and hyperglycemic agent. J Pharmacol Exp Ther. 1961; 133:90-97.
15. Norton S. Quantitative determination of mast cell fragmentation by compound 48/80. Br J Pharmacol, 1954; 9:494–7.
16. Anil K, Rawal P, Nanjan M. J, Suresh B, Solomon F. Emerson and Prabakar S. Herbex-kid Inhibits Immediate Hypersensitivity Reactions in Mice and Rats eCAM 2008; 5(3), 289–294.
17. Black J. The role of mast cells in the pathophysiology of asthma. N Engl J Med, 2002; 346: 1742-1743.