Author(s): M. Santhosh Raja, K. Venkataramana

Email(s): santhosh.raja88@gmail.com

DOI: 10.5958/0974-360X.2020.00900.2   

Address: M. Santhosh Raja1*, K. Venkataramana2
1Research Scholar, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Guntur- 522510, India.
2A.S.N. Pharmacy College, Burripalem Road, Tenali, Guntur- 522201, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Glipizide is a sulfonylurea used for the treatment of diabetes mellitus. Glipizide belongs to BCS class II which possess low solubility and high permeability which is a great disadvantage in administration of drug. One of the finest approaches to increase the solubility is preparation of nanoparticles. A simple formulation approach for preparation of nanosuspension of Glipizide is performed using HPMC K 15 M, PVP K 30, Eudragit L 100 as polymers and Poloxamer 188 as stabilizer by nano precipitation method. The formed nanosuspension was evaluated for various evaluation parameters like particle size, zetapotential, drug content and dissolution testing. The compatibility between the drug and ingredients are checked by using DSC. The best formulation containing the 2.0% of Eudragit L 100 showed the particle size of 98-107nm, Zeta potential of -55.3±1. The invivo studies of G12 formulation is conducted on Wistar rats for estimation of various pharmacokinetic parameters showed better profile when compared to pure drug. Hence nanoprecipitation was successfully employed for the preparation of Glipizide nanosuspension to improve the bioavailability.


Cite this article:
M. Santhosh Raja, K. Venkataramana. Formulation and Evaluation of Stabilized Glipizide Nanosuspension prepared by Precipitation Method. Research J. Pharm. and Tech. 2020; 13(11):5145-5150. doi: 10.5958/0974-360X.2020.00900.2


REFERENCES:
1.    Ramaiyan D, Vijaya Ratna J. Nanosuspensions technology in drug delivery – A review. International Journal of Pharmacy Review and Research. 2012; 2 (1), 46-52.
2.    Murthy RSR. In Vitro Evaluation of NPDDS. In: Yashwant Pathak, Deepak Thassu, Drug Delivery Nanoparticles Formulation and Characterization. London: Informa Health Care. 2009; 156-168.
3.    Vishal RP, Agrawal YK. Nanosuspension: An approach to enhance solubility of drugs. Journal of Advanced Pharmaceutical Technology and Research. 2011; 2 (2), 81-87.
4.    Barrett E. Rabinow. Nanosuspensions in drug delivery. Nature Reviews. 2004; 3 (0), 785-796.
5.    Sarika V. Khandbahale. A Review- Nanosuspension Technology in Drug Delivery System. Asian J. Pharm. Res. 2019; 9(2): 130-138.
6.    Pawar Pravin, Yadav Adhikrao, Gharge Varsha. Different Techniques for Preparation of Nanosuspension with Reference to its Characterisation and various Applications - A Review. Asian J. Res. Pharm. Sci. 2018; 8(4): 210-216.
7.    Rajashri R. Kulkarni, Dipti G. Phadtare, Ravindra B. Saudagar. A Novel Approach Towards Nanosuspension. Asian J. Pharm. Res. 5(4): 2015;186-194.
8.    Atul Phatak, Pallavi Jorwekar, P.D. Chaudhari. Nanosuspensions: A Promising Nanocarrier Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 176-182.
9.    Vijay Shinde, P Amsa, S Tamizharasi, D Karthikeyan, T Sivakumar, Abhijit Kosalge. Nanosuspensions: A Promising Drug Delivery Strategy. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 39-44.
10.    Muller RH, Dingler A, Schneppe T, Gohla S. Large-Scale Production of Solid Lipid Nanoparticles (SLN) and Nanosuspensions (DissoCubes). In: Donald L. Wise, Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker. 2000; 359-375.
11.    Amidon GL, Lennarnas H, Shah VP, Crison JR. A Theoretical Basis for a Biopharmaceutical Classification: The correlation of invitro product dissolution and invivo Bioavailability. Pharmaceutical Research. 1995; 12 (3), 413-420.
12.    V.V. Nageswara Rao, K.V. Ramana Murthy. Formulation and Evaluation of Modified Pulsincap Technique for Oral Controlled Release of Glipizide. Research J. Science and Tech. 2012; 4(1): 9-12.
13.    Salma Banu S.K., Venkateswara Rao T.. Design and Development of Sustained Release Bilayered Tablets of Glipizide. Research J. Pharma. Dosage Forms and Tech. 2012; 4(1):24-31.
14.    N. Sandhya Rani, M. Teja Krishna, V. Saikishore. Design and Development of Sweet Potato Starch Blended Sodium Alginate Mucoadhesive Microcapsules of Glipizide. Research J. Pharma. Dosage Forms and Tech. 2012; 4(2): 119-123.
15.    Jinal Patel, Nirav Patel, Nagesh C., Chandrashekhar S., Moin K. Modasiya. Formulation and evaluation of floating tablet of glipizide using different polymers. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 185-191.
16.    Amolkumar Lokhande, Satyendra Mishra, Ravindra Kulkarni, Jitendra Naik. Formulation And Evaluation Of Glipizide Loaded Nanoparticles. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5 (4), 147-151.
17.    Dhaval Patel, Priyanka Chaudhary, S. Mohan, Hiren Khatri. Enhancement of Glipizide dissolution rate through nanoparticles: Formulation and invitro evaluation. e journal of science and technology. 2012; 7 (4), 19-31.
18.    Ghasemian Elham, Parvizi Mahsa, Alireza Vatanara, Ramezani Vahid. Spray drying of nanoparticles to form fast dissolving glipizide. Asian Journal of Pharmaceutics. 2015; 9 (3), 213-218.
19.    Koneti Venkata Mahesh, Sachin Kumar Singh, Monica Gulati. A comparative study of top-down and bottom-up approaches for the preparation of nanosuspensions of glipizide. Powder Technology. 2014; 256 (0), 436-449.
20.    Muddana EBR, Suryakanta S, Chinam NP, Shakti PM. Formulation Design, Optimization and Characterization of Eprosartan Mesylate Nanoparticles. Nanoscience and Nanotechnology-Asia. 2018; 8 (1), 130-143.
21.    Date AA, Jain A, Khachane P, Nagarsenker MS. Organic solvent-free approach to single step fabrication of Eudragit nanoparticles using Labrasol. Pharmazie. 2010; 65 (0), 733-736.
22.    Pradeep Kumar M, Chandra Sekhar KB, Bioavailability and Dissolution enhancement of Glyburide Nanosuspension. Asian Journal of Pharmaceutical and clinical Research. 2019; 12(4),111-118
23.    John Pugh. Kinetics and product stability. In: M.E Aulton Pharmaceutics, The science of dosage form design. 2nd ed. Edinburgh: Churchill Livingstone. 1986; 101-105.
24.    Higuchi T. Mechanism of Sustained- Action Medication, Theoretical Analysis of Rate of Release of Solid Drugs Dispersed in Solid Matrices. Journal of Pharmaceutical Sciences. 1963; 52 (12), 1145-1149.
25.    Philip L Ritger, Nikolaos A Peppas. A simple equation for description of solute release I. Fickian and Non-Fickian release from non swellable devices in the form of slabs, spheres, cylinders or discs. Journal of Controlled Release. 1987; 5, 23-36.

Recomonded Articles:

Author(s): Nimbalkar V.V., Pansare P.M., Nishane B.B.

DOI: 10.5958/0974-360X.2015.00310.8         Access: Open Access Read More

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Muhammad Hamdan, Noorhamdani AS, Masruroh Rahayu, Mohammmad Hasan Machfoed

DOI: 10.5958/0974-360X.2019.01020.5         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Raj Kumar R, Praveen D, Palani Shanmugasundaram

DOI: 10.5958/0974-360X.2016.00164.5         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Vaseeha Banu T.S., Sandhya K.V., K.N. Jayaveera

DOI: Not Available         Access: Open Access Read More

Author(s): Trophimus Gnanabagyan Jayakaran, Vignesh R, Shankar P

DOI: 10.5958/0974-360X.2019.00700.5         Access: Open Access Read More

Author(s): Manju Rawat, SJ Daharwal, Deependra Singh

DOI:         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags