Author(s): Nikeherpianti Lolok, Selpirahmawati, Nurlena Ikawati, Wa Ode Yuliastri, Muhammad Isrul

Email(s): nikeherpianti.apt@gmail.com

DOI: 10.5958/0974-360X.2020.00898.7   

Address: Nikeherpianti Lolok, Selpirahmawati, Nurlena Ikawati, Wa Ode Yuliastri, Muhammad Isrul
Department of Pharmacy, STIKES Mandala Waluya Kendari.
*Corresponding Author

Published In:   Volume - 13,      Issue - 11,     Year - 2020


ABSTRACT:
Diabetes mellitus is a metabolic syndrome that can cause a lot of complicated disease. Application of natural product is one of alternative treatment that has commonly been applied by the society since then, that is black (Oryza sativa L. Indica) and red (Oryza nivara) ricebran. The aim of this study is to understand the effectivity of black rice bran (Oryza sativa L. Indica) extract and redrice bran (Oryza nivara) extract to the deflation of blood glucose in tested animal induced glucose compare to negative control and to understand the effectivity of red rice bran extract and black rice bran extract combination to the deflation of blood glucose in tested animal induced glucose compare to metformin and glibenclamide combination. In this study, samples were extracted by maceration method using ethanol 96%. The assays of antidiabetic effect divided into 3 groups those are negative control, positive control and combination of the extract. Data analysist were conducted using One-way ANOVA and continuing with LSD (Low Significant Difference) test. The result of the test to the mice induced diabetes revealed that combination of the red rice bran extract and black rice bran extract significantly able to reduce blood glucose compare to negative control (p<0.05), but the result do not reveal that combination of the red rice bran extract and black rice bran extract able to reduce blood glucose level of the diabetic induced mice.


Cite this article:
Nikeherpianti Lolok, Selpirahmawati, Nurlena Ikawati, Wa Ode Yuliastri, Muhammad Isrul. Antidiabetic effects of Red Rice Bran Extract (Oryza nivara) and Black Rice Bran Extract (Oryza sativa L. Indica) in Wistar white rat by Glucose Induction Method. Research J. Pharm. and Tech. 2020; 13(11):5134-5138. doi: 10.5958/0974-360X.2020.00898.7


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