Rajkumar S. Bagali, Sunil S. Jalalpure, S. S. Patil
Rajkumar S. Bagali1*, Sunil S. Jalalpure2, S. S. Patil3
1Department of Pharmacology, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, India.
2Department of Pharmacognosy and Phytochemistry, K.L.E. University, College of Pharmacy, Nehrunagar, Belgaum-10, Karnataka, India.
3Department of Pharmaceutics, Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, India.
Volume - 13,
Issue - 11,
Year - 2020
Herbal medicines provide rational means for the treatment of many diseases that are obstinate and incurable in other systems of medicine but it is necessary to establish the scientific basis for the therapeutic actions of herbal plant medicines. Schrebera swietenioides fruit ethanolic extract was studied for the hepatoprotective activity against CCl4 induced liver injury in rats. Serum enzymes level, total bilirubin and histopathological study of liver were performed. This extract’s DPPH radical scavenging potential was also studied. Oral administration of ethanolic extract of Schrebera swietenioides fruit (200mg/kg) exhibited significant reduction (p<0.05) in CCl4-induced increased levels of SGPT, SGOT, ALP and bilirubin (Total) concentration. Treatment with Liv 52 syrup also reversed the hepatotoxicity significantly (p<0.05). Histopathological studies also provided supportive evidence for biochemical analysis. This extract also showed better activity in quenching DPPH radical. The antioxidant property of ethanolic extract of Schrebera swietenioides fruit prevented the formation of trichloromethyl peroxy radical thereby reducing tissue damage which is further confirmed by the histopathological study. Therefore, the hepatoprotective activity of ethanolic extract of Schrebera swietenioides fruit may be due to its antioxidant potential. Since there are reports that the plants containing steroids and saponins possess antioxidant properties, the hepatoprotective and antioxidant properties of the test plant may be attributed to the presence steroids and saponins. Schrebera swietenioides fruit ethanolic extract shown to have hepatoprotective and antioxidant action.
Cite this article:
Rajkumar S. Bagali, Sunil S. Jalalpure, S. S. Patil. Evaluation of Schrebera swietenioides Roxb. fruit Ethanolic extract for Antioxidant and Hepatoprotective activity against CCl4 induced liver injury in rats. Research J. Pharm. and Tech. 2020; 13(11):5115-5120. doi: 10.5958/0974-360X.2020.00895.1
1. C Girish, BC Koner, S Acanthi, KR Rao. Hepatoprotective activity of six polyherbal formulations in CCl4 -induced liver toxicity in mice. Indian Journal of Experimental Biology 2009; 47: 257-63.
2. Harman D. Free radical theory of aging: Current status. Amsterdam. Elsevier 1998; 3-7.
3. Kappus H. Oxidative Stress. London, Academic Press. 1995; 273.
4. Osawa T, Kavakishi S, Namiki M, Kuroda Y, Shankal DM, Waters MD. Antimutagenesis and anticarcinogenesis mechanisms II, New York, Plenum 1990; 139-53.
5. Babu BH, Shylesh BS, Padikkala J. Antioxidant and hepatoprotective effects of Acanthus ilicifolius. Fitoterapia 2001; 72: 272-7.
6. Nadkarni, A.K. Indian Materia Medica, Vol. I., Popular Prakashan Pvt. Ltd., Bombay 1996; 184–185.
7. Kirtikar, K.R. and Basu, B.D. Indian Medicinal Plants, Vol. II. International Book Publisher, Dehradun 1993; 1531–2.
8. Hansraj Manda, Baboo K Rao, Yashwant., Gopalan N. Kutty. and Surendra K Swarnkar. Antioxidant, Anti-Inflammatory and Antipyretic Activities of Ethyl Acetate Fraction of Ethanolic Extract of Schrebera swietenioides Roxb. Root. Intl Jl of Toxicological and Pharmacological Research 2009; 1(1), 7-11.
9. Umamaheshwari M, K Asokkumar, R Rathidevi, AT Sivashanmugam, V Subhadradevi, TK. Ravi. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. Journal of Ethnopharmacology 2007; 110:464-70.
10. VI Hukkeri, KS Aakki, RR Sureban, B Gopalakrishna, VV Byahatti, SV Rajendra. Hepatoprtoective activity of the leaves of Nyctanthes arbor-tristis Linn. Indian Journal of Pharm. Sciences 2006; July-Aug: 542-3.
11. Ilhami Gulcin, Riad Elias, Akcahan Gepdiremen, Laurent Boyer, Ekrem Koksal. A comparative study on the antioxidant activity of fringe tree (Chionanthus virginicus L.) extracts. African Journal of Biotechnology 2007; 6 (4): 410-8.
12. Rashmi DR, Subramaniam V. In Vitro antioxidant activity of medicinally important Achyranthes aspera- a preliminary study. Indian drugs 2006; 44(2): 128-31.
13. Yamini, B Tripathi, Savita Chaurasia, Ekta Tripathi, Anil Upadhey, GP Dubey. Bacopa monniera Linn. as an antioxidant: Mechanism of action. Indian Journal of Experimental Biology 1996; 34:523-6.
14. MN Qureshi, BS Kuchekar, NA Logade, MA. Haleem. In-vitro Antioxidant and In-vivo Hepatoprotective activity of Leucas ciliata leaves. Rec. Nat. Prod. 2010; 4(2): 124-30
15. Pramod Kumar, Deval RG, Lakshmayya, Ramachandra Setty S. Antioxidant and hepatoprotective activity of tubers of Momordica tuberosa Cogn. against CCl4 induced liver injury in rats. Indian Journal of Experimental Biology 2008; 46: 510-3.
16. Chaudhari BP, Chaware VJ, Joshi YR, Biyani KR. Hepatoprotective activity of hydroalcoholic extract of Momordica charantia Linn. leaves against Carbon tetra chloride induced Hepatopathy in Rats. International Journal of Chem Tech Research 2009; 1 (2): 355-8.
17. Reema Srivastava, Pankaj Srivastava. Hepatotoxicity and the role of some herbal hepatoprotective plants in present scenario. Global Journal of Digestive Diseases.2018;4-2(3):1-4.
18. Saurabh Nimesh, Tinku Kumar and Shubham. An updated review on hepatoprotective potential of medicinal plants. ACTA Scientific Medical Sciences. 2019, 3 (7), 99-105.
19. Vikrant Arya, Raneev Thakur. Plant Saponins –A Recent Update. Asian Journal of Research in Chemistry.2013;6(9):871-6.
20. C P Mahajan, A N. Aher. A Review on Ethnobotanical, Phytochemical and Pharmacological activities of Quisqualis indica Linn. Research Journal of Pharmacognosy and Phytochemistry. 2017;9(1):47-52.
21. Fellah, K., Amrouche A., Benmehdi H., Memmou F. Phenolic profile, antioxidants and kinetic properties of flavonoids and Tannins Fractions isolated from Prunus persica L. leaves growing in Southwest Algeria. Research Journal of Pharmacy and Technology.2019; 12(9):4365-72.
22. J. Angel Steffy, M. Henna Parveen, V. Durga, S. Manibalan. Extraction purification of phlorotannins from different species of marine algae and Evaluation of their Anti-Oxidant potential. Research J. Engineering and Tech. 2013:4(4): 163-8.
23. Kavitha Sagar, Soma Aneesha, Pooja Uppin, Gowthami. Phytochemical studies and quantification of total content of Phenols, tannins and flavonoids in selected endangered plant species. Research Journal of Pharmacognosy and Phytochemistry.2018; 10(4): 277-81.
24. Njoku Obioma U., Joshua, Parker Elijah, Ossai Emmanuel C., Agu, Chidozie Victor, Ugwuanyi Juliana O. Antioxidant properties of Murraya koenigii. Asian J. Research Chem.2011; 4(10): 1549-52.
25. Preeti Tiwari. Estimation of Total phenolics and flavonoids and antioxidant Potential of Amritarishta Prepared by Traditional and Modern Methods. Asian J. Research Chem. 2013; 6 (12): 1173-8.
26. Joshi Uttara, Upadhye Mohini. Evaluation of antioxidant activity of aqueous extract bark of Ficus Glomerata. Research J. Pharm. and Tech.2008 1(4): 537-8.
27. Kanagavalli M. And Anuradha R. A Study on Phytochemical constituents and in vitro antioxidant activity of Carica papaya. Research J. Pharm. and Tech.2012; 5 (1):119-20.
28. M. Vaishali. Antioxidants in health and diseases. Research J. Pharm. and Tech. 2014; 7(4): 489-93.
29. Rangarajan Narasimhan, Sathiyamoorthy. M. Phytochemical screening and antioxidant studies in the pulp extracts of Cucurbita maxima. Asian J. Pharm. Res. 2016; Vol. 6: 1-4.
30. Rekha Rajendran, N Saleem Basha. S Ruby. Evaluation of In vitro antioxidant activity of stem-bark and stem-wood of Premna serratifolia Lin., (Verbenaceae). Research J. Pharmacognosy and Phytochemistry 2009; 1(1):11-14.