Author(s):
Vaishali J. Mahadik, Monika N. Chavare, S. S. Patil, Kiran A. Wadkar
Email(s):
vaishali.mpharma@gmail.com
DOI:
10.5958/0974-360X.2020.00886.0 
Address:
Vaishali J. Mahadik1*, Monika N. Chavare2, S. S. Patil3, Kiran A. Wadkar4
1Ph.D. Research Scholar, Faculty of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, India.
2Assistant Professor, Shree Santkrupa Shikshan Sanstha’s College of Pharmacy, Ghogaon, Maharashtra, India.
3Assistant Professor, Department of Pharmacology, Aappasaheb Birnale College of Pharmacy, Sangali, Maharashtra, India.
4Head of Deparment of Pharmacognocy, Aappasaheb Birnale College of Pharmacy, Sangali, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 11,
Year - 2020
ABSTRACT:
The present study was performed to investigate the cognition enhancing effect of various extracts of fruits of Sesbania grandiflora, pet ether extract (PESG), benzene extract (BESG), chloroform extract (CESG), acetone extract (AESG) and ethanolic extract (EESG) in scopolamine induced amnesia in mice Methods: Morris water maze (MWM) and Elevated plus maze (EPM) test was done to evaluate cognitive performance. To explore beneficial effect of various extracts of fruits of Sesbania grandiflora PESG, BESG, CESG, AESG, EESG was administered to mice for 15 days. Scopolamine (0.4mg/kg, i.p) was administered to mice after 45 minutes of extract administration on 15th day. Piracetam (200mg/kg p.o.) was used as standard drug. Various biochemical parameters such as acetylcholineesterase (AchE), malondiadehyde (MDA), and Glutathion level (GSH) from brain homogenate were evaluated on 19th day. Result: Pretreatment with BESG,CESG,AESG,EESG extract of Sesbania grandiflora (200mg/kg p.o) showed increase in transfer latency (TL) and increase in inflexion ratio (IR) in EPM and increase in escape latency time (ELT) and time spend in target quadrant (TSTQ) in MWM while decrease in TL and IR in EPM and decrease in ELT and TSTQ was observed in scopolamine induced amnesia. Pretreatment of BESG, CESG, AESG, EESG extract of fruits of Sesbania grandiflora significantly decrease MDA level and increases GSH level as compared to scopolamine induced amnesic mice. Conclusion: The findings from present investigation may conclude that extracts of fruits of Sesbania grandiflora possesses cognition enhancing property in scopolamine induced amnesia in mice.
Cite this article:
Vaishali J. Mahadik, Monika N. Chavare, S. S. Patil, Kiran A. Wadkar. Cognition Enhancing potential of Sesbania grandiflora fruit extract in Scopolamine induced Amnesia in mice. Research J. Pharm. and Tech. 2020; 13(11):5057-5062. doi: 10.5958/0974-360X.2020.00886.0
Cite(Electronic):
Vaishali J. Mahadik, Monika N. Chavare, S. S. Patil, Kiran A. Wadkar. Cognition Enhancing potential of Sesbania grandiflora fruit extract in Scopolamine induced Amnesia in mice. Research J. Pharm. and Tech. 2020; 13(11):5057-5062. doi: 10.5958/0974-360X.2020.00886.0 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-11-1
REFRENCES:
1. Mahboubi M. Melissa officinalis and rosmaric acid in management of memory functions and Alzheimer disease. Asian Pacific Journal of Tropical Biomedicine2019; 9(2): 47-52.
2. Pattanashetti LA, Taranalli AD, Parvatrao V, Malabade RH, Kumar D. Evaluation of neuroprotective effect of quercetin with donepezil in scopolamine –induced amnesia in rats. Indian Journal of Pharmacology 2017;49:60-4.
3. Surabhi, Singh BK. Alzheimer’s disease: A comprehensive review. International Journal of Pharmaceutical Sciences and Research 2019; 10(3) : 993-1000.
4. Liu Z, Zhang A, Sun H, Han Y, Kong L, Wang X. Two decades of new drug discovery and development for Alzheimer’s disease. Royal Society of Chemistry. 2017;7: 6046-6058.
5. Mani A, Chaudhary A, Maurya P, Yadav B, Singh S. Current therapeutic targets for Alzheimer’s. disease. Journal of Biomedicine 2018;3:74-84.
6. Hopper S, Udawela M, Scarr E, Dean B. Allosteric modulation of cholinergic system: Potential approach to treating cognitive deficits of schizophrenia. World Journal of Pharmacology s2016;(5)1:32-43.
7. Kucca K, Soukup O, Maresova P: Current approaches against Alzheimer’s disease in clinical trials. Journal of Brazilian. Chemical Science 2016;27: 641-649.
8. Joshi H, Parle M: Zingiber officinale: Evaluation of its nootropic effect in mice. African Journal of Traditional Complementary and Alternative Medicines 2006;3:64-74.
9. Andrade C, Monteiro I, Hedge RP, Chandra JS. Investigation of the possible role of Shankapushpi in the attenuation of ECT induced amenestic deficits. Indian Journal of Psychiatry 2012;54:166-71.
10. Neelam, Patekar R, Choudhary A, Soni G, Dwivedi K: Concept of medhya rasayana in aurveda: An Overview. International Journal of Research in Ayurveda Pharm 2017;8 :78-81.
11. Chaudhari K, Murthy A. R: Effect of Rasayana on Mental health-a review study. International Journal of Ayurveda and Alternative Medicine. 2014; 2:1-7.
12. Kirtikar B. D., Basu B. D. Indian Medicinal Plants.1998; 2735.
13. Nadkarni A.K. Nadkarni K.M. Indian material medica.1982;3, 52-54
14. Deshpande A. P. Javalgekar R. R. Rande S., Dravyaguna Vijnyan,2013;820-821.
15. Joshi H, Parle M: Zingiber officinale: Evaluation of its nootropic effect in mice. African Journal of Traditional Complementary and Alternative Medicines 2006;3:64-74.
16. Morris R. Spatial localization dose not depend on the presence of local cues. Learning and Motivation 1981;12: 239-260
17. Ellman G, Courtney KD, Andres VJ. Feather-Stone RM. Anew and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol1961; 7:88-95
18. Ohkawa H, Ohishi N, Yagi K, Assay of lipid peroxidase tissue by thiobarbituri acid reaction. Anal Biochem 1979; 95:351-358.
19. Ellman G, Courtney KD, Andres VJ. Feather-Stone RM. Anew and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol1961; 7:88-95
20. Jawaid T, Shakya A, Siddiqui H, Kamal M. Antiamnesic activity of leaves of Bambusa arunndinacea in rats. An International Journal of Advances in Pharmaceutical Sciences. 2013;4(5):919-932.
21. Malabade R, Taranalli A. Cassia tora A potential cognition enhancer in rats with experimentally induced amnesia 2015;7(4):455-461
22. Young K, Jeong E, Lee K, Kim S, Sung S. Cognitive –enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine- treated mice.
23. Rao N, Pujar B, Nimba S, Shanta Kumar S, Satyanarayana S. Nootropic activity of tuber extract of Pueraria tuberose (Roxb) 2008;46:591-598.
24. Uddin S, Nasruah, Hossain S Evaluation of nootropic activity of Persicaria flaccida on cognitive performance, brain antioxidant markers and acetylcholinesterase activity in rats; implication for the management of Alzheimer’s Disease. American Journal of Psychiatry and Neuroscience 2016;4(2):26-35.
25. Muralidharan P, Balamurugan G, Venu Bapu. Cerebroprotective effect of Glycyrrhiza glabra Linn.root extract on hypoxic rats. Bangladesh J Pharmacology 2009; 4:60-64.
26. Khare P, Chaudhary S, Singh L, Yadav G, Verma S. Evaluation of Nootropic activity of Cressa cretica in scopolamine –induced memory impairment in mice. International Journal of Pharmacology and Toxicology 2014;2(2):24-29.
27. Parle M, Kaura S. Anti-Alzheimer Potential of Green Moong Bean 2016;37(2): 178-182.
28. Uddin S, Nasruah, Hossain S Evaluation of nootropic activity of Persicaria flaccida on cognitive performance, brain antioxidant markers and acetylcholinesterase activity in rats; implication for the management of Alzheimer’s Disease. American Journal of Psychiatry and Neuroscience 2016;4(2):26-35.