Katolkar P Parimal, Hirulkar R Mayuresh, Baheti R Jagdish, Meshram S Satish
Katolkar P Parimal, Hirulkar R Mayuresh*, Baheti R Jagdish, Meshram S Satish
Kamla Nehru College of Pharmacy, Butibori, Nagpur.
Volume - 13,
Issue - 10,
Year - 2020
Endocrine disorders are common in India of which the thyroid disorder represent a major subset. In Indian population, thyroid dysfunction prevalence is rising at an alarming rate. Hypothyroidism and hyperthyroidism constitute the maximum percentage of thyroid diseases in India. The need to combat thyroid dysfunction has risen in recent years due to its increasing prevalence. Hormone replacement has been the choice of therapy. However, alternative medicinal approaches are gaining popularity in view of their efficacy with minimal side effects. This review throws light on various drugs of plant origin which have proven action on thyroid and its functioning and also on the various factors associated with thyroid dysfunction.
Cite this article:
Katolkar P Parimal, Hirulkar R Mayuresh, Baheti R Jagdish, Meshram S Satish. Herbal Anti-Thyroid Drugs: An Overview. Research J. Pharm. and Tech. 2020; 13(10):5045-5051. doi: 10.5958/0974-360X.2020.00884.7
1. Tortora GJ. and Derrickson B. Principles of Anatomy and Physiology. John Wiley and Sons Inc. 2012;13th ed; pp: 697.
2. Fox SI. Human Physiology. Mc Graw Hill. 2010;12th ed; pp: 338.
3. Lakshmi CM. Scientific Basis for Ayurvedic Therapies. CRC Press LLC, New York Wasinghton D.C. 2004, pp:133-48.
4. Nagarathna PKM, Deepa KJ. Study on Antithyroid property of some herbal plants review article. International Journal of Pharmaceutical Sciences Review and Research. 23(2);2013:203-11.
5. Anderson S, Bruun NH, Pedersen KM, Laurberg P. Biologic variation is important for interpretation of Thyroid function tests. Thyroid. 13(11):2003;1069-78.
6. Harrison TR. Harrisons principles of Internal medicine, Edited by Kasper Dennis L, Fauci Anthony S, Longo Dan L, et.al, Published by McGraw Hill, Medical publishing division. 2005;16th ed.
7. Harrison TR, Harrisons principles of Internal medicine, Edited by Kasper Dennis L, Fauci Anthony S, Longo Dan L, et.al, Published by McGraw Hill, Medical publishing division. 2005;16th ed.
8. Brent G A. Clinical practice–graves disease. The New England Journal of Medicine. 358;2008:2594-2605.
9. Bartalena L, Bogazzi F, Martino E, Adverse effect of thyroid Hormone Preparation and antithyroid Drugs istituto di endocrinologia ,University of psia, Itly. 15(1);1996:53-63.
10. Abdel Wahhab KG. Mourad HH, Mannaa FA, Morsy FA, Hassan LK and Taher R F. Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats. Molecular Biology Reports. 46;2019:3637–3649.
11. Mary Shomon (2012). A Review. Available from: URL: http://www.ehow.com/way_5215104_herbal-treatments thyroid.html.13
12. Chandra AK and De N. Goitrogenic and Antithyroid Potential of Green Tea of Indian Origin. Journal of Bangladesh Society of Physiologist. 9(2);2015 :105-116.
13. Kim M and Lee BC. Therapeutic Effect of Scutellaria baicalensis on L-Thyroxine-Induced Hyperthyroidism Rats. Evidence-Based Complementary and Alternative Medicine. (Special issue); 2019:1–8.
14. Gaitan E, Lindsay RH, Reichert RD, Ingbar SH, Cooksey RC, Legan J, Kubota K. Antithyroid and Goitrogenic Effects of Millet: Role of C-Glycosylflavones. The Journal of Clinical Endocrinology and Metabolism. 68(4);1989:707–714.
15. Sartelet H, Serghat S, Lobstein A, Ingenbleek Y, Anton R, Petitfrère E, Haye B. Flavonoids extracted from fonio millet (Digitaria exilis) reveal potent antithyroid properties. Nutrition. 12(2);1996:100–106.
16. Beer AM, Wiebelitz KR and Schmidt Gayk H. Lycopus europaeus (Gypsywort): Effects on the thyroidal parameters and symptoms associated with thyroid function. Phytomedicine. 15(1-2);2008:16–22.
17. Santini F, Vitti P, Ceccarini G, Mammoli C, Rosellini V, Pelosini C, Pinchera A. In-vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. Journal of Endocrinological Investigation. 26(10);2003:950–955.
18. Udoh P, NJV R, Udoh F. Effect of Carica Papaya seeds ethanolic extract on the pitutory gland of male wister rats. Global Journal of pure and applied science. 10(4);2000:515-517.
19. Auf'mkolk M, et al., Extracts and auto-oxidized constituents of certain plants inhibit the receptor-binding and the biological activity of Graves' immunoglobulins. Endocrinology.116(5);1886:l1687-1693.
20. Gholap S and Kar A. Effects of Inula racemosa root and Gymnema sylvestre leaf extracts in the regulation of corticosteroid induced diabetes mellitus: Involvement of thyroid hormones. Die Pharmazie. 58(6);2203:413–415.
21. Panda S and Kar A. Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: Possible involvement of quercetin. Phytomedicine. 14(12); 2007:799–805.
22. Panda S and Kar A. How safe is neem extract with respect to thyroid function in male mice? Pharmacological Research. 41(4); 2000:419–422.
23. Panda S and Kar A. Inhibition of T3 production in levothyroxine-treated female mice by the root extract of Convolvulus pluricaulis. Hormone and Metabolic Research. 33(1);2001:16–19.
24. Bove M, Stansbury JE and Romm A. Endocrine Disorders and Adrenal Support. Botanical Medicine for Women’s Health. 2010; 2nd ed: pp 191
25. Panda S, Bharti S and Kar A. Emblica officinalis and Bauhinia purpurea in the regulation of thyroid function and lipid peroxidation in male mice. Journal of Herbs, Spices and Medicinal Plants. 10(1);2002:1–9
26. Panda S and Kar A. Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse. Pharmacological Research. 38(2);1998:107–110.
27. Tabassum W, Kullu AR and Sinha MP. Effect of leaf extracts of Moringa oleifera on regulation of hypothyroidism and lipid profile. The Bioscan Supplement on Medicinal Plants. 8(2),2013:665–669.