Herbal medicines have been commonly used around the world since prehistoric times. The innovation of phytochemical and phytopharmacological sciences has enabled explanation of the composition and biological activities of several herbal plant products. The usefulness of many species of therapeutic plants depends on the contribution of active compounds. Most of the organically energetic materials of extracts such as flavonoids, tannins, and terpenoids are fantastically soluble in water but have low absorption because they are unable to pass the lipid membranes of the cells, have excessively excessive molecular size or are poorly absorbed that results in loss of bioavailability and efficacy. Some extracts are not used clinically due to the fact of these obstacles. It has been substantially proposed to combine natural medicine with nanotechnology, due to the fact nanostructured structures might to potentiate the motion of plant extracts, lowering the required dose and aspect effects, and enhancing activity. Nano drug delivery system can deliver the active constituent at a sufficient attention during the entire treatment period, directing it to the preferred site of action. Conventional treatments do not meet these necessities. The purpose of this study is to review nanomedicines based drug delivery system and their significant role in herbal formulations be able
Cite this article:
Ankur Choubey, Pawan Bajpai, Shelesh Jain. Nanomedicines based Drug delivery system and their significant role in Herbal Formulations: A Review. Research J. Pharm. and Tech. 2020; 13(10):5034-5039. doi: 10.5958/0974-360X.2020.00881.1
Ankur Choubey, Pawan Bajpai, Shelesh Jain. Nanomedicines based Drug delivery system and their significant role in Herbal Formulations: A Review. Research J. Pharm. and Tech. 2020; 13(10):5034-5039. doi: 10.5958/0974-360X.2020.00881.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-10-84
1. Swamy MK, Sinniah UR. Patchouli (Pogostemon cablin Benth.): botany, agrotechnology and biotechnological aspects. Ind Crops Prod. 2016; 87:161–76.
2. Mohanty SK, Swamy MK, Sinniah UR, Anuradha M. Leptadenia reticulata (Retz.) Wight and Arn. (Jivanti): botanical, agronomical, phytochemical, pharmacological, and biotechnological aspects. Molecules. 1019; 2017:22.
3. Rodrigues T, Reker D, Schneider P, Schneider G. Counting on natural products for drug design. Nat Chem. 2016; 8:531.
4. Siddiqui AA, Iram F, Siddiqui S, Sahu K. Role of natural products in drug discovery process. Int J Drug Dev Res. 2014;6(2):172–204.
5. Costa EMMB, Barbosa AS, Arruda TA, et al. Estudo in vitro da ação antimicrobiana de extratos de plantas contra Enterococcus faecalis [In vitro antimicrobial activity of plant extracts against Enterococcus faecalis] J Bras Patol Med Lab. 2010;46(3):175–180.
6. Verma S, Singh SP. Current and future status of herbal medicines. Vet World. 2008;1(11):347–350.
7. Bresolin TMB, Filho VC. Fármacos e medicamentos: uma abordagem multidisciplinar [Drugs and medicines: a multidisciplinary approach] São Paulo: Santos; 2010. Portuguese.
8. Mazzolin LP, Nasser ALM, Moraes TM, et al. Qualea parviflora Mart.: an integrative study to validate the gastroprotective, antidiarrheal, antihemorragic and mutagenic action. J Ethnopharmacol. 2010;127(2):508–514.
9. Yadev D, Suri S, Choudhary AA, Sikender M, Heman, Beg MN et al. Novel approach, herbal remedies and natural products in pharmaceutical science as nano drug delivery systems. International Journal of Pharm Tech Research. 2011; 3(3):3092-3116.
10. Ratnam DV, Ankola DD, Bhardwaj V, Sahana DK, Kumar MN. Role of antioxidants in prophylaxis and therapy: a pharmaceutical prospective. J Control Release. International Journal of Molecular Sciences. 2006; 113:189-207.
11. McNamara K, Tofail SA. Nanosystems: the use of nanoalloys, metallic, bimetallic, and magnetic nanoparticles in biomedical applications. Phys Chem Chem Phys. 2015; 17:27981–95.
12. Saadeh Y, Vyas D. Nanorobotic applications in medicine: current proposals and designs. Am J Robot Surg. 2014; 1:4–11.
13. Oliveira ON Jr, Iost RM, Siqueira JR Jr, Crespilho FN, Caseli L. Nanomaterials for diagnosis: challenges and applications in smart devices based on molecular recognition. ACS Appl Mater Interfaces. 2014; 6:14745–66.
14. De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomed. 2008; 3:133.
15. Holzinger M, Le Goff A, Cosnier S. Nanomaterials for biosensing applications: a review. Front Chem. 2014; 2:63.
16. Golovin YI, Gribanovsky SL, Golovin DY, Klyachko NL, Majouga AG, Master AM, Sokolsky M, Kabanov AV. Towards nanomedicines of the future: remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields. J Control Release. 2015; 219:43–60.
17. Lu H, Wang J, Wang T, Zhong J, Bao Y, Hao H. Recent progress on nanostructures for drug delivery applications. J Nanomater. 2016; 2016:20.
18. Blanco E, Shen H, Ferrari M. Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biotechnol. 2015; 33:941.
19. Kumari A, Kumar V, Yadav S. Nanotechnology: a tool to enhance therapeutic values of natural plant products. Trends Med Res. 2012; 7:34–42.
20. Liu M, Dong J, Yang Y, Yang X and Xu H: Antiinflammatory effects of triptolide loaded poly (d.l-lactic acid) nanoparticles on an adjuvant-induced arthritis in rats. Journal of ethnopharmacology 2005; 97: 219-225.
21. Sahu A, Bora U, Kasoju N and Goswami P: Synthesis of novel biodegradable and self-assembling methoxy poly (ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomaterialia 2008; 4:1752- 61.
22. Zhang L, Kosaraju SL: Biopolymeric delivery system for controlled release of polyphenolic antioxidants. European polymer journal 2007; 4: 32956-66.
23. Bhatia A, Shard P, and Chopra D, Mishra T: Chitosan nanoparticles as carrier of immunorestoratory plant extract: synthesis, characterization and immunorestoratory.
24. Iwaki T, Kakihara Y, Toda T, Abdullah M, Okuyama K. Preparation of High Coercivity Magnetic FePt Nanoparticles by Liquid Process. Journal of Applied Physics. 2003; 94:6807-6811.
25. Sohn BH, Cohen RE, Chem Mater. Processible optically transparent block copolymerfilms containing super paramagnetic iron oxide nano preparation. 1991; 9(1):264-269.
26. Dong X, Mattingly CA, Tseng MT, J Cho Moo, Liu Y, Adams VR: Doxorubicin and Paclitaxel-loaded lipid Based Nanoparticles to overcome Multidrug Resistance by inhibiting P-Glycoprotein and Depleting ATP. Cancer Research 2009; 69: 3918-26.
27. Shi F, Zhao JH, Liu Y, Wang Z, Zhang YT, Feng NP: Preparation and characterization of solid lipid nanoparticles loaded with frankincense and myrrh oil. International journal of nanomedicine 2012; 7: 2033-43.
28. Hu LD, Xing Q, Meng J and Shang C: Preparation and enhanced bioavailability of cryptotanshinone-loaded solid lipid nanoparticles. AAPS Pharm Sci Tech 2010; 11: 582-7.