Author(s): Meena Kharwade, Sanjeevani Deshkar, Arati Halyali, Arun Satpute

Email(s): ,

DOI: 10.5958/0974-360X.2020.00879.3   

Address: Meena Kharwade1, Sanjeevani Deshkar2*, Arati Halyali2, Arun Satpute2
1Anjuman-I-Islam Kalsekar Technical Campus, School of Pharmacy, New Panvel, Navi Mumbai-410206, Maharashtra.
2Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, Maharashtra.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020

Increasing the popularity of herbal medicines in the recent times has attracted the global market and expected to rise by more than 90% in next five years. Many herbal extracts and phytoconstituents having excellent proven in-vitro bioactivity, fail to demonstrate therapeutic action in vivo because of their poor lipid solubility, high molecular size or first pass metabolism. Traditional formulations of phytoconstitutents are primarily administered by oral route but unable to trounce the above confines resulting in low bioavailability and less patient adequacy due to frequent administration. Drug administration via topical route has gained the attention of the researcher because of ease of administration, local drug targeting, patient compliance, controlled drug delivery and bypassing first pass. Literature review indicated the use of nano vesicular systems based on phospholipids for the topical application of phytoconstituents. Mainly vesicular systems like, transferosomes, phytosomes, niosomes, ethosomes and cubosomes are reported for thriving delivery of drug phytoconstituents. These systems can augment the skin drug transport in a secure and proficient ways by drug partitioning into the skin, fusing the lipids in formulation with lipid in the stratum corneum and fluidizing skin lipids. Current review focuses on the major vesicular systems used for the formulations and their application in delivery of phytopharmaceuticals through skin.

Cite this article:
Meena Kharwade, Sanjeevani Deshkar, Arati Halyali, Arun Satpute. Phytopharmaceutical delivery through skin: Recent updates on delivery by Vesicular carriers. Research J. Pharm. and Tech. 2020; 13(10):5018-5025. doi: 10.5958/0974-360X.2020.00879.3

Meena Kharwade, Sanjeevani Deshkar, Arati Halyali, Arun Satpute. Phytopharmaceutical delivery through skin: Recent updates on delivery by Vesicular carriers. Research J. Pharm. and Tech. 2020; 13(10):5018-5025. doi: 10.5958/0974-360X.2020.00879.3   Available on:

1.    Manisha Y, Bhatia VJ, Doshi G, Shastri K. Novel techniques in herbal drug delivery systems. Int J Pharm Sci Rev Res 2014;28(2):83–9.
2.    Parth S, Surajpal V, Plakshi M. Global need for novel herbal drug formulations. International Journal of Pharmacognosy and Phytochemical Research 2016;8(9):1535-44.
3. 2017.
4.    Ajazuddin, Saraf S. Applications of novel drug delivery system for herbal formulations. Fitoterapia Elsevier B.V 2010;81(7):680–89.
5.    Benson HA. Transdermal drug delivery: Penetration enhancement techniques. Curr Drug Deliv 2005;2: 23-33.
6.    Shashank J, Niketkumar P, Mansi KS, Pinak K, Namrata V. Recent advances in lipid-based vesicles and particulate carriers for topical and transdermal application. Journal of Pharmaceutical Sciences 2017; 106 (2):423-445.
7.    Yosra SR, Elnaggar, Wessam MERM, Ossama YA. Lecithin-based nanostructured gels for skin delivery: An update on state of art and recent applications. Journal of Controlled Release 2014;180:10-24.
8.    Chandrashekar N, Rani RS. Physicochemical and pharmacokinetic parameters in drug selection and loading for transdermal drug delivery. Indian J Pharm Sci 2008;70: 94-6.
9.    Nida A, Anurag V, Kamla P. Exploring preclinical and clinical effectiveness of nanoformulations in the treatment of atopic dermatitis: Safety aspects and patent reviews. Bulletin of Faculty of Pharmacy 2017; 55 (1):1-10.
10.    Nava D. Pathways for skin penetration. Cosmetics and Toiletries magazine 2005;120 (6):67-76.
11.    Purohit DK, Nandgude TD, Poddar SS. Nano-lipid carriers for topical application: Current scenario. Asian J Pharm 2016; 9:1-9.
12.    Jadhav SM, Morey P, Karpe M, Vilasrao K. Novel vesicular system: An overview. J Appl Pharm Sci 2012; 2:193-202.
13.    More SB, Nandgude TD, Poddar SS, Vesicles as a tool for enhanced topical drug delivery, Asian J Pharm 2016;10:196–208.
14.    Mayank G. Recent advances in various emerging vesicular systems: an overview. Asian Pacific Journal of Tropical Biomedicine 2012; 2 (2): S1176-S1188.
15.    Seema MJ, Pournima M, Manisha K, Vilasrao K. Novel vesicular system: an overview. Journal of Applied Pharmaceutical science 2012; 2(1):193-202.
16.    Namdeo GS, Nagesh HA, Ajit SK. Recent advances in vesicular drug delivery system. Research Journal of Pharmaceutical Dosage Forms and Technology 2014;6(2): 110-20.
17.    Lee EH, Kim A, Oh YK, Kim CK. Effect of edge activators on the formation and transfection efficiency of ultradeformable liposomes. Biomaterials 2005;26(2):205-10.
18.    Oh YK, Kim MY, Shin JY, Kim TW, Yun MO, Yang SJ et al. Skin permeation of retinol in Tween 20-based deformable liposomes: in-vitro evaluation in human skin and keratinocyte models. J Pharm Pharmacol. 2006;58(2):161-66.
19.    Ankit G, Geeta A, Samita S, Ritika A. Transfersomes: A novel vesicular carrier for enhanced transdermal delivery of sertraline: development, characterization, and performance evaluation. Sci Pharm 2012; 80(4):1061–80
20.    Cevc G, Schätzlein A, Gebauer D, Blume G. Ultra-high efficiency of drug and peptide transfer through the intact skin by means of novel drug-carriers, transfersomes. Prediction of Percutaneous Penetration 1993; Cardiff; 1993:226–34.
21.    Naseem A, Riaz AK. Liposomal systems as viable drug delivery technology for skin cancer sites with an outlook on lipid-based delivery vehicles and diagnostic imaging inputs for skin conditions. Progress in Lipid Research 2016;64:192-230.
22.    Zhongguo Zhong Yao ZaZhi. Preparation of transferosomes of vicristinesulfate and study on its precutaneous penetration. Chinese 2005;30(12): 900-03.
23.    Patel R, Singh SK, Singh S, Sheth NR, Gendle R. Development and characterization of curcumin loaded transfersome for transdermal delivery. J Pharm Sci & Res 2009;1(4):71-80.
24.    Sarwa KK, Mazumder B, Rudrapal M, Verma VK. Potential of capsaicin-loaded transfersomes in arthritic rats. Drug delivery 2015;22(5):638-46.
25.    Celia C, Cilurzo F, Trapasso E, Cosco D, Fresta M, Paolino D. Ethosomesand transfersomes containing linoleic acid: physicochemical and technological features of topical drug delivery carriers for the potential treatment of melasma disorders, Biomedical Microdevices 2011;6:105-11.
26.    Choi JH, Cho SH, Yun JJ, Yu YB, Cho CW. Ethosomes and transfersomes for topical delivery of gin-senoside from red ginseng: characterization and in vitro evaluation. J Nanosci Nanotechnol 2015;15:5660–72.
27.    Zheng Y, Hou SX, Chen T, Lu Y. Preparation and characterization of transfersomes of three drugs in vitro. China J Chin Mater Med 2006;31(9):728–31.
28.    Patel J, Patel R, Khambholja K, Patel N. An overview of phytosomes as an advanced herbal drug delivery system, Asian J Pharm Sci 2009;4:363–71.
29.    Rajendra A, Giriraj TK, Vivek KP. Phytosomes: an approach to increase the bioavailability of plant extracts. International Journal of Pharmacy and Pharmaceutical Sciences 2011;3(2):1-¬3.
30.    Bhattacharya S, Ghosh A. Phytosomes: the emerging technology for enhancement of bioavailability of botanicals and nutraceuticals. The Internet Journal of Aesthetic and Antiaging Medici 2009; 2 (1): 141‐53.
31.    Bhattacharya S. Phytosomes: emerging strategy in delivery of herbal drugs and nutraceuticals. Pharma Times 2009; 41(3): 9‐12.
32.    Chauhan NS, Gowtham R, Gopalakrishna B. Phytosomes: a potential phytophospholipid carriers for herbal drug delivery. J Pharm Res 2009; 2 (7): 1267-70.
33.    Bhupen K, Malay K.D., Anil Kumar S. Novel Phytosome Formulations in Making Herbal Extracts More Effective. Research Journal of pharmacy and technology 2013; 6(11):1295-1301.
34.    Pande SD, Wagh AS, Bhangare LB, Patil SG, Deshmukh AR. Preparation and Evaluation of Phytosomes of Pomegranate Peels. Research Journal of pharmacy and technology 2015; 8(4): 416-422.
35.    Franco PG, Bombardelli E. Complex compound of bioflavonoids with phospholipids, their preparation and use and pharmaceutical and cosmetic composition containing them. EPTO No. EP0275005 1989; 6-14.
36.    Loggia RD, Sosa SA, Tubaro P, Morazzoni EB, Griffini A. Anti-inflammatory activity of some Gingko biloba constituents and of their phospholipids-complexes. Fitoterapia 1996;3: 257-73.
37.    Bombardelli E. Bilobalide derivatives, their applications and formulations containing them. United States Patent 5202313
38.    Sandhya S, Chandra SJ, Vinod KR, Rao KNV, Banji D. Preclinical studies of a novel polyherbalphyto–complex hair growth promoting cream. Asian Pacific Journal of Tropical Biomedicine 2012;2: S296-S304.
39.    Freag MS, Elnaggar YS, Abdallah OY. Lyophilized phytosomal nanocarriers as platforms for enhanced diosmin delivery: optimization and ex vivo permeation. Int J Nanomedicine 2013; 8:2385–90
40.    Malay KD, Bhupen K. Design and evaluation of phyto-phospholipid complexes (phytosomes) of rutin for transdermal application. J app pharm sci 2014; 4(10):51-7.
41.    Damle M, Mallya R. Development and Evaluation of a Novel Delivery System Containing Phytophospholipid Complex for Skin Aging. AAPS Pharm SciTech 2016; 17(3):607–617
42.    Ljiljana D, Danina K, Zorica M, Bojan C. Formulation and physicochemical characterization of hydrogels with 18b-glycyrrhetinic acid/phospholipid complex phytosomes. Journal of Drug Delivery Science and Technology 2016; 35: 81-90.
46.    Sankhyan A, Pawar P. Recent trends in niosome as vesicular drug delivery system. J Appl Pharm Sci2012; 2:20–32.
47.    Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery—an overview. Acta Pharm Sin B 2011; 1:208–19.
48.    Baena-Aristizábal CM, Mora-Huertas CE. Micro, nano and molecular novel delivery systems as carriers for herbal materials. J Colloid SciBiotechnol2013; 2:263–97.
49.    Kapil K, Rai AK. Development and evaluation of proniosome-encapsulated curcumin for transdermal administration. J Pharm Res 2011;10 (6): 697-703.
50.    Manosroi A, Jantrawut P, Akihisa T, Manosroi W, Manosroi J. In-vitro and in-vivo skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from Terminaliachebula galls. Pharm Biol2011; 49:1190–203.
51.    Chandel A, Saroha K, Nanda S. Preparation and evaluation of proniosomal gel of neem seed oil. International Journal of Pharmaceutical Sciences and Nanotechnology 2012;5(3):1780-84.
52.    Manosroi A, Chutoprapat R, Abe M, Manosroi W, Manosroi J. Anti-aging efficacy of topical formulations containing niosomes entrapped with rice bran bioactive compounds. Pharm Biol 2012;50(2):208-24.
53.    Yeh MI, Huang HC, Liaw JH, Huang MC, Huang KF, Hsu FL. Dermal delivery by niosomes of black tea extract as a sunscreen agent. Int J Dermatol2013;52(2):239-45.
54.    Rabia NU, Baris FB. Phyto-Niosomes: In Vitro Assessment of the novel nanovesicles containing marigold extract. International Journal of Polymeric Materials 2015; 64(17):927–37.
55.    Mahboobeh R, Abbas P, Fariba S, Mehrnaz M, Hojjat N, Mitra M. Phytoniosome: a novel drug delivery for myrtle extract. Iran J Pharm Res 2018; 17(3): 804–17.
56.    Peng X, Zhou Y, Han K. Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. Drug Des DevelTher 2015; 9:4209-18.
57.    Bhosale RR, Osmani RA, Harkare BR and Ghodake PP. Cubosomes-the inimitable nanoparticulate drug carriers. SchAcad J Pharm. 2013;2(6):481-86.
58.    Madhurilatha T, Paruchuri SK, Suria P. Overview of cubosomes-A nano particle. IJRPC 2011;1(3):535-41.
59.    Ramya Sri V, Madhusudhanreddy A, Karthikeyan R, SrinivasababuP.a review on: cubosomes drug delivery system. Indian Journal of Drugs 2017; 5(3): 104-08.
60.    Aubine molly B, Prasanthi NL. Cubic liquid crystalline nanoparticles (cubosomes): a novel carrier for drug delivery. IJPSR 2019;10(3): 973-84.
61.    Archana A, Vijaya SK, Madhuri M and Kumar CHA. Curcumin loaded nanocubosomal hydrogel: Preparation, in-vitro characterization and antibacterial activity. Chemical Science Transaction 2005; 4(1): 75-80.
62.    Peng X, Yang Z, Chen M, Han K, Xiao Y, Wu C. Preparation, characterization and content determination of cubic phase gel containing capsaicin. Chinese 2010;35(23):3123–26.
63.    Peng XS, Zhou YF, Han K, Qin LZ, Wu CB. Preparation and in vitro study on diffusion of capsaicin cubosome. Chinese 2014;39(4):644–47.
64.    Xinsheng P, Yanfang Z, Kehan LQ, linghui D, Ge li, Xin Pan, chuanbin Wu. Characterization of cubosomes as a targeted and sustained transdermal delivery system for capsaicin. Drug Design, Development and Therapy 2015;9: 4209–18.
65.    Taek Kwan Kwon, Jin-Chul Kim. Preparation and in vitro skin permeation of cubosomes containing Hinokitiol. Journal of Dispersion Science and Technology 2010; 31:1004-09.
66.    Kwon TK, Lee HY, Kim JD, Shin WC, Park SK, Kim JC. In-vitro skin permeation of cubosomes containing water-soluble extracts of Korean barberry. Colloid J 2010; 72(1): 205-10.
67.    Hong SK, Ma JY, Kim JC. In vitro skin permeation enhancement of KIOMMA-128 by monooleincubosomes. J Dispersion Sci Technol 2012; 33:1503–08.
68.    Ree S, Gu S, Jeong K, Ha W, Kim JC. In-vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions. J Ind Eng Chem 2013; 19(4): 1331-39.
69.    Rakesh R, Anoop KR. Ethosomes for transdermal and topical drug delivery. Int J Pharm Sci 2012; 4(3): 17-24.
70.    Touitou E, Dayan N, Bergelson L, Godin B, Eliaz M. Ethosomesnovel vesicular carriers for enhanced delivery: characterization and skin penetration properties, Journal of Controlled Release 2000;65 403‐18.
71.    Dubey V, Mishra D, Dutta T, Nahar M, Saraf D.K, Jain N.K. Dermal and transdermal delivery of an anti‐psoriatic agent viaethanolic liposomes. Journal of Controlled Release 2007;123:148–54.
72.    Nidhi N, Sunil J, Ranjit S, Vikas A. Transdermal applications of ethosomes – a detailed review. Journal of Liposome Research 2018. 1–32.
73.    Jobin J, Shweta Shetty, Sandeep DS, Prashanth Nayak. Ethosomes as a Promising Delivery Carrier for Herbal Drugs: Recent Developments. Research Journal of pharmacy and technology 2018; 11(7): 3197-3200.
74.    Amala M, Sneh P. Nanosized Ethosomes – A Promising Vesicular Drug Carrier for Transdermal Drug Delivery. Research Journal of pharmacy and technology 2019; 12(2):876-880.
75.    Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M. Ethosomes for skin delivery of ammoniumglycyerrizhate: in vitro percutaneous permeation through human skin and in vivo anti-inflammatory activity on human volunteer. J Control Release 2005;106:99–110.
76.    Zhaowu Z, Xiaoli W, Yangdel Z, Nianfeng L. Preparation of matrine ethosome, its percutaneous permeation in vitro and anti-inflammatory activity in vivo in rats. J Liposome Res. 2009;19(2):155–62.
77.    Swarnlata S, Gunjan J, Chanchal DK, Shailendra S. Development of novel herbal cosmetic cream with Curcuma longa extract loaded transfersomes for antiwrinkle effect. African Journal of Pharmacy and Pharmacology 2011; 5(8):1054-62.
78.    Liu X, Liu H, Liu J, He Z, Ding C, Huang G. Preparation of a ligustrazine ethosome patch and its evaluation in vitro and in vivo. Int J Nanomedicine 2011;6:241-7.
79.    Zhao YZ, Lu CT, Zhang Y, Xiao J, Zhao YP, Tian JL, Xu YY, Feng ZG, Xu CY. Selection of high efficient transdermal lipid vesicle for curcumin skin delivery. Int J Pharm 2013;454(1):302-9.
80.    Ming-Jun T, Yaw-Bin H, Jhih-Wun F, Yaw-Syan F, Pao-Chu W. Preparation and characterization of naringenin-loaded elastic liposomes for topical application. PLOS ONE 2015;10(7): e0131026.
81.    Nimisha, Khushboo S, Amrit KS. Formulation and evaluation of sea buck thorn leaf extract loaded ethosomal gel. Asian J Pharm Clin Res 2015;8(5):13;316-20.
82.    Yu Z, Lv H, Han G, Ma K. Ethosomes Loaded with Cryptotanshinone for Acne Treatment through Topical Gel Formulation. PLOS ONE 2016;11(7):e0159967.
83.    Nimisha K, Fatima Z, Kaur CD. Formulation and performance evaluation of Berberis aristata extract loaded ethosomal gel. Asian J Pharm 2017;11:176-83.
84.    Sachin BS, Shivanand NH. Development and evaluation of novel ethosomal vesicular drug delivery system of Sesamum indicum L. Seed Extract. Asian Journal of Pharmaceutics 2018;12 (4): S1282-87.
85.    De Pintu K, De Arnab. Pharmacosomes: a potential drug delivery system. International Research Journal of Pharmacy 2012;3:102–5.
86.    Kavitha D, Naga Sowjanya J, Panaganti S. Pharmacosomes: an emerging vesicular system. International Journal of Pharmaceutical Sciences Review and Research 2010;5(3):168–171.

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