Author(s): R. Narayana Charyulu, Gautami Biswas, Travassos Pearl Wilma, Fiona Melreen Castelino, Ravi G. S.

Email(s): ravi@nitte.edu.in

DOI: 10.5958/0974-360X.2020.00805.7   

Address: R. Narayana Charyulu, Gautami Biswas, Travassos Pearl Wilma, Fiona Melreen Castelino, Ravi G. S.*
Department of Pharmaceutics, N.G.S.M Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Mangaluru – 575018, Karnataka, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
Scopolamine hydrobromide is the hydrobromide salt form of scopolamine and has anticholinergic, antiemetic and antivertigo properties. Its property of reducing the saliva secretion also reported. Orodispersible films are solid dosage forms, which disintegrate or dissolve within a minute when placed in the oral cavity. In order to overcome the drawback of the conventional scopolamine hydrobromide solution as antisialagogue we formulated the scopolamine hydrobromide orodispersible films by solvent casting method using pullulan and HPMC E15 polymer combination. The formulations were statistically optimized by full factorial design (32) using Design Expert® software. The optimized formulations were evaluated in vivo. The optimized formulations exhibited acceptable physical characteristics with good flexibility, folding endurance, tensile strength. As anticipated, the optimized scopolamine hydrobromide orodispersible films exhibited quick disintegration and drug release. From the in vitro disintegration and drug release study it was observed that the formulation F1 disintegrated in 9 ± 1 sec and ~98.37 drug was release at the end of 120 sec. Hence the scopolamine hydrobromide orodispersible films successfully tailored for the use in dentistry as an antisialagogue formulation.


Cite this article:
R. Narayana Charyulu, Gautami Biswas, Travassos Pearl Wilma, Fiona Melreen Castelino, Ravi G. S. Development of Scopolamine Hydrobromide Orodispersible Films as an Anti-sialagogue in Dentistry: Optimization and in vitro Evaluation. Research J. Pharm. and Tech. 2020; 13(10):4570-4578. doi: 10.5958/0974-360X.2020.00805.7


REFERENCES:
1.    Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. Journal of Pharmaceutical Sciences. 1992;81(1):1-10.
2.    Bartlett JA, Maarschalk KV. Understanding the oral mucosal absorption and resulting clinical pharmacokinetics of asenapine. AAPS Pharm Sci Tech. 2012;13(4):1110-5. doi:10.1208/s12249-012-9839-7.
3.    Reddy PC, Chaitanya KSC, Rao YM. A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods. DARU Journal of Pharmaceutical Sciences. 2011;19(6):385-403.
4.    Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. European Journal of Pharmaceutics and Biopharmaceutics. 2011;77(2):187-99. doi:10.1016/ j.ejpb.2010.11.023.
5.    Reddy MS, Shruthi B, Mounika B, Sowmya G. Fast dissolving drug delivery system - A review. Research Journal of Pharmacy and Technology. 2013:6(1):4-11.
6.    Clissold SP, Heel RC. Transdermal hyoscine (Scopolamine). A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1985;29(3):189-207.
7.    Spinks A, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database of Systematic Reviews. 2011;(6):CD002851. doi:10.1002/ 14651858.CD002851.pub4.
8.    Talmi YP, Finkelstein Y, Zohar Y. Reduction of salivary flow with transdermal scopolamine: a four-year experience. Otolaryngology–Head and Neck Surgery. 1990;103(4):615-8.
9.    Bala R., Pawar P., Khanna S., Arora S. Orally dissolving strips: A new approach to oral drug delivery system. International Journal of Pharmaceutical Investigation. 2013;3(2):67-76. doi:10.4103/ 2230-973X.114897.
10.    Jose J, Ashwini PB, Nayak P, Charyulu RN. Oral dispersible films, novel technology for the delivery of drugs. Research Journal of Pharmacy and Technology. 2019;12(1):425-8. doi:10.5958/ 0974-360X.2019.00077.5.
11.    Prabhu P, Malli R, Koland M, Vijaynarayana K, D’Souza U, Harish NM, et al. Formulation and evaluation of fast dissolving films of levocitirizine di hydrochloride. International Journal of Pharmaceutical Investigation. 2011;1(2):99-104. doi:10.4103/ 2230-973X.82417.
12.    Bhagat BV, Darkunde S. Orodispersible film: A novel drug delivery system. Research Journal of Pharmacy and Technology. 2014;7(10):1196-200.
13.    Ravi GS, Geena V, Joshi J, Justine O, Sharanya P, Charyulu NR, et al., Design and characterization of aloe emodin dental implants for the treatment of dental caries. International Journal of Pharmaceutical Sciences Review and Research. 2018;51(1):12-8.
14.    Ayorinde JO, Odeniyi MA, Agbaje BO. Formulation and evaluation of oral dissolving films of amlodipine besylate using blends of starches with hydroxypropyl methyl cellulose. Polymers in Medicine. 2016;46(1):45-51. doi:10.17219/pim/65098.
15.    Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast-dissolving film of salbutamol sulphate. Drug Development and Industrial Pharmacy. 2005;31(1):25-34. doi:10.1081/DDC-43947.
16.    Shirsand SB, Suresh S, Kusumdevi V, Swamy PV. Formulation design and optimization of fast dissolving clonazepam tablets by sublimation method. Indian Journal of Pharmaceutical Sciences. 2011;73(5):491-6. doi:10.4103/0250-474X.98984.
17.    Bala R, Sharma S, IKGPTU. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bulletin of Faculty of Pharmacy, Cairo University. 2018;56(2018):159-68. doi:10.1016/j.bfopcu.2018.04.002.
18.    Tappiti E, Velmurugan S, Reddy GN. Formulation and evaluation of loratadine fast dissolving films. Research Journal of Pharmacy and Technology. 2014;7(3):310-5.
19.    Chaithanya P, Charyulu RN, Sandeep DS. Design and evaluation of ebastine fast dissolving oral films. International Journal of Pharmaceutical Sciences and Research. 2018;9(10):4303-8. doi:10.13040/IJPSR.0975-8232.9(10).4303-08.
20.    Semalty A, Semalty M, Nautiyal U. Formulation and evaluation of mucoadhesive buccal films of enalapril maleate. Indian Journal of Pharmaceutical Sciences. 2010;72(5):571-5. doi:10.4103/0250-474X.78522.
21.    Birla N, Mandloi K, Mandloi R, Pillai S. Formulation and evaluation of quick dissolving films of promethazine hydrochloride. Research Journal of Pharmacy and Technology. 2017;10(4):1025-8. doi:10.5958/0974-360X.2017.00185.8.
22.    Salehi S, Boddohi S. New formulation and approach for mucoadhesive buccal film of rizatriptan benzoate. Progress in Biomaterials. 2017;6: 175-87. doi:10.1007/s40204-017-0077-7.
23.    Senthilkumar K, Vijaya C. Formulation development of mouth dissolving film of etoricoxib for pain management. Advances in Pharmaceutics. 2015; 2015:702963. doi.10.1155/2015/702963.
24.    Jayarao YR, Deborah D, Ambedkar T, Babu SM. Formulation and evaluation of fast dissolving oral films of perindopril. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014;6(2):71-80.
25.    Nirmala D, Nandhini S, Sudhakar M. Design and evaluation of fast dissolving oral films of zolpidem by solvent casting method. Asian Journal of Pharmaceutical Research. 2016;6(2):67-71. doi:10.5958/2231-5691.2016.00012.5.
26.    Verma U, Rajput R, Naik JB. Development and characterization of fast dissolving film of chitosan embedded famotidine using 32 full factorial design approach. Materials Today: Proceedings. 2018;5(1):408-14. Doi.org/10.1016/j.matpr.2017.11.099.
27.    Srinivas A, Bhikshapathi DVRN. Fast dissolving oral films of pramipexole HCl monohydrate: Preparation and in vitro evaluation. Research Journal of Pharmacy and Technology. 2018;11(3):1001-8. doi:10.5958/0974-360X.2018.00187.7.
28.    Sanjay P, Gupta VN, Gowda DV, Sivadasu P. Formulation and evaluation of oral disintegrating film of atenolol. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(8):312-5. doi:10.22159/ajpcr.2018.v11i8.26464.
29.    Kengeri S, Nagesh C, Naduvinamani S, Attimarad SL, Jorapur D, Chandrasekhara S, et al. Design and characterization of quick dissolving film for simultaneous delivery of montelukast sodium and levocetirizine dihydrochloride. Research Journal of Pharmacy and Technology. 2018;11(5):1705-12. doi:10.5958/0974-360X.2018.00317.7.
30.    Bansal S, Bansal M, Garg G. Formulation and evaluation of fast dissolving film of an antihypertensive drug. International Journal of Pharmaceutical, Chemical and Biological Sciences. 2013;3(4):1097-1108.
31.    Prabhu P, Dubey A, Kamath K. Formulation and evaluation of fast-dissolving films of lisinopril. Egyptian Pharmaceutical Journal. 2015;14: 56-64. doi:10.4103/1687-4315.154723.
32.    Maddela S, Nalluri BN. Development of rizatriptan mouth dissolving films: A fast absorbing drug delivery system for effective treatment of migraine. Research Journal of Pharmacy and Technology. 2019;12(6):2907-16. doi:10.5958/0974-360X.2019.00490.6.
33.    Londhe VY, Umalkar KB. Formulation development and evaluation of fast dissolving film of telmisartan. Indian Journal of Pharmaceutical Sciences. 2012;74(2):122-6. doi:10.4103/0250-474X.10384.

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