Author(s): Puppala Raman Kumar, Vijaya Lakshmi A

Email(s): ram4599@gmail.com

DOI: 10.5958/0974-360X.2020.00875.6   

Address: Puppala Raman Kumar*, Vijaya Lakshmi A
Department of Pharmaceutical Technology, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
There has been considerable interest in drug delivery research over the past few decades using particulate delivery systems as carriers for large and small molecules. Particulate structures such as nanoparticles were used as a physical method to modify and enhance the pharmacokinetic and pharmacodynamic properties of different types of drug molecules. Nanoparticles (NP) are classified as particles with a diameter of less than 100 nm and are increasingly used in various applications, including drug carrier systems, passing through barriers to organs such as the blood-brain barrier. Due to their unique properties, nanocrystals (quantum dots) and other nanoparticles (gold colloids, nanobars, dendrimers and nanoshells) have received a great deal of attention for possible use in Therapeutics and therapeutic drug discovery. The use of nanotechnology in medicine is expected to spread rapidly, and more precisely, the delivery of drugs. Several drugs are currently under investigation for drug delivery and cancer therapy in particular. Ironically, pharmaceutical sciences use nanoparticles to minimize the toxicity and side effects of drugs, and they have not realized until recently that carrier systems can impose risks on the patient themselves. All these aspects of NP are discussed in the present article.


Cite this article:
Puppala Raman Kumar, Vijaya Lakshmi A. An Overview on Nanobased Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(10):4996-5003. doi: 10.5958/0974-360X.2020.00875.6

Cite(Electronic):
Puppala Raman Kumar, Vijaya Lakshmi A. An Overview on Nanobased Drug Delivery System. Research J. Pharm. and Tech. 2020; 13(10):4996-5003. doi: 10.5958/0974-360X.2020.00875.6   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-10-78


REFERENCES:
1.    Langer R. Biomaterials in drug delivery and tissue engineering: one laboratory's experience. Acc Chem Res 2000; 33: 94-101.
2.    Bhadra D, Bhadra S, Jain P, Jain NK. Pegnology: a review of PEG-ylated systems. Pharmazie 2002; 57: 5-29.
3.    Kommareddy S, Tiwari SB, Amiji MM. Long-circulating polymeric nanovectors for tumour-selective gene delivery. Technol Cancer Res Treat 2005; 4: 615-625.
4.    Lee M, Kim SW. Polyethene glycol-conjugated copolymers for plasmid DNA delivery. Pharm Res 2005; 22: 1-10.
5.    Vila A, Sanchez A, Tobio M, Calvo P, Alonso MJ. Design of biodegradable particles for protein delivery. J Control Release 2002; 78: 15-24.
6.    Mu L, Feng SS. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol(R)): PLGA nanoparticles containing vitamin E TPGS. J Control Release 2003; 86: 33-48.
7.    P. Venkatesan, V. Sree Janardhanan, C. Muralidharan, and K. Valliappan. Acta Chim. Slov., 2012; 59: 242–248.
8.    Kannappan Valliappan, Sree Janardhanan Vaithiyanathan and Venkatesan Palanivel. Chromatographia, 2013; 76(5): 287-292.
9.    Redhead, H. (1997). “Drug loading of biodegradable nanoparticles for site-specific drug delivery”. The University of Nottingham Nottingham.
10.    Dange YD, Honmane SM, Patil PA, Gaikwad UT, Jadge DR. Nanotechnology, Nanodevice Drug Delivery System: A Review. Asian J. Pharm. Tech. 2017; 7(2): 63-71.
11.    http://www.nanotechnologydevelopment.com/products/introduction-to- nanoparticles.html
12.    Jameel Ahmed Mulla, Sarasija Suresh, Imtiyaz Ahmed Khazi. Formulation, Characterization and in vitro Evaluation of Methotrexate Solid Lipid Nanoparticles. Research J. Pharm. and Tech. 2009; 2(4): 685-689.
13.    Amol S. Deshmukh. Solid Lipid Nanoparticles. Res. J. Pharm. Dosage Form. and Tech. 6(4):Oct.- Dec.2014; Page 282-285.
14.    Baviskar Anagha, Hiremath Shivanand, Akul Manoj, Pawar Poonam. Effect of Lipids and Surfactants on Solid Lipid Nanoparticle Engineering. Research J. Pharm. and Tech. 2011; 4(4):521-526.
15.    Trilochan Satapathy, Prasanna Kumar Panda. Solid Lipid Nanoparticles: A Novel Carrier in Drug Delivery System. Research J. Pharma. Dosage Forms and Tech. 2013; 5(2): 56-61.
16.    Surbhi Sharma, M.S. Ashawat, N.S. Solanki. Isotretinoin-Loaded Solid-Lipid Nanoparticles: A Sound Strategy for Skin Targeting. Research J. Pharm. and Tech. 5(11):November, 2012; Page 1375-1384.
17.    Khopde AJ, Jain, NK. Dendrimer as a potential delivery system for bioactive In Jain NK, editor. Advances in controlled and novel drug delivery. CBS publisher, New Delhi, 2001, 361-80.
18.    P. Venkatesan et al. / International Journal of Pharmaceutical and Biomedical Research. 2011; 2(3): 107-117.
19.    R. Sathiya Sundar, A. Murugesan, P. Venkatesan, and R. Manavalan, Formulation Development and Evaluation of Carprofen Microspheres. Int.J. Pharm Tech Research. 2010; 2(3):1674-1676.
20.    P. Venkatesan, R. Manavalan and K. Valliappan Microencapsulation: A Vital Technique In Novel Drug Delivery System. J. Pharm. Sci. and Res. 2009; 1(4):26-35.
21.    Hussain N, Jani PU, Florence AT. Enhanced oral uptake of tomato lectin-conjugated nanoparticles in the rat. Pharm Res 1997; 14: 613-8.
22.    A. Arunkumar et al.,: Formulation, Evaluation and Optimization of Sustained Release Bilayer tablets of Niacin and Green Tea extract by employing Box-Behnken design, J. Sci. Res. Phar., 2016; 5(2): 23-28.
23.    Fasiuddin Arif Mohammad, Kishore Rapolu, Shanthan Kumar Valugonda, Srinivas Balusu. Optimization of Cuprous Oxide Nanocrystals Deposition on Multiwalled Carbon Nanotubes. Asian J. Research Chem. 2012; 5(1):116-124.
24.    Wanigasekara J, Witharana C. Applications of nanotechnology in drug delivery and design-an insight. Current Trends in Biotechnology and Pharmacy. 2016; 10(1):78-91.
25.    Zhang Y, Chan HF, Leong KW. Advanced materials and processing for drug delivery: the past and the future. Advanced drug delivery reviews. 2013; 65(1):104-20.
26.    Sridhar R, Ramakrishna S. Electrosprayed nanoparticles for drug delivery and pharmaceutical applications. Biomatter. 2013 Jul 19; 3(3):e24281.
27.    Gelperina S, Kisich K, Iseman MD, Heifets L. The potential advantages of nanoparticle drug delivery systems in the chemotherapy of tuberculosis. American journal of respiratory and critical care medicine. 2005 Dec 15; 172(12):1487-90.
28.    Stevenson CL, Santini Jr JT, Langer R. Reservoir-based drug delivery systems are utilizing microtechnology. Advanced drug delivery reviews. 2012 Nov 1; 64(14):1590-602.
29.    Bamrungsap S, Zhao Z, Chen T, Wang L, Li C, Fu T, Tan W. Nanotechnology in therapeutics: a focus on nanoparticles as a drug delivery system. Nanomedicine. 2012 Aug; 7(8):1253-71.
30.    Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Bouamrani A, Hu T, Ranganathan SI, De Rosa E. Enabling individualized therapy through nanotechnology. Pharmacological research. 2010 Aug 1; 62(2):57-89.
31.    Jabir NR, Tabrez S, Ashraf GM, Shakil S, Damanhouri GA, Kamal MA. Nanotechnology-based approaches in anticancer research. International journal of nanomedicine. 2012; 7:4391.
32.    Bae YH, Park K. Targeted drug delivery to tumours: myths, reality and possibility. Journal of controlled release. 2011 Aug 10;153(3):198.
33.    Dong X, Mumper RJ. Nanomedicinal strategies to treat multidrug-resistant tumours: current progress. Nanomedicine. 2010 Jun;5(4):597-615.
34.    Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Letters. 2010 Aug 20;10(9):3223-30.
35.    Calixto G, Bernegossi J, Fonseca-Santos B, Chorilli M. Nanotechnology-based drug delivery systems for treatment of oral cancer: a review. International journal of nanomedicine. 2014; 9:3719.
36.    Kompella UB, Amrite AC, Ravi RP, Durazo SA. Nanomedicines for the back of the eye drug delivery, gene delivery, and imaging. Progress in retinal and eye research. 2013; 36:172-98.
37.    Savita More, Sarika Lokhande, Vijay Raje. Review on Solid Lipid Nanoparticles for Ophthalmic Delivery. Res. J. Pharma. Dosage Forms and Tech.2019; 11(1):19-34.
38.    Bhaskar S, Tian F, Stoeger T, Kreyling W, de la Fuente JM, Grazú V, Borm P, Estrada G, Ntziachristos V, Razansky D. Multifunctional Nanocarriers for diagnostics, drug delivery and targeted treatment across the blood-brain barrier: perspectives on tracking and neuroimaging. Particle and fibre toxicology. 2010;7(1):3.
39.    K Srikanth, M Nappinnai, VRM Gupta. Proniosomes: A Novel Drug Carrier System. Research J. Pharm. and Tech.3. 2010; 3(3): 709-711.
40.    Subhashis Debnath, R. Suresh Kumar, M. Niranjan Babu. Ionotropic Gelation – A Novel Method to Prepare Chitosan Nanoparticles. Research J. Pharm. and Tech. 2011; 4(4): 492-495.
41.    Utpal Jana, Sovan Pal, G.P. Mohanta, P.K. Manna, R. Manavalan. Nanoparticles: A Potential Approach for Drug Delivery. Research J. Pharm. and Tech. 2011; 4(7):1016-1019.
42.    Svapnil Sanghavi, Misam Polara, Dipil Patel, Ruchita Shah, Jayvadan Patel, Manish Patel. Nanoparticle Drug Delivery to Brain – A Review. Research J. Pharm. and Tech. 2012; 5(1): 8-13.

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