Author(s): T. Prannoy, P. K. Lakshmi

Email(s): drlakshmisuresh@gmail.com

DOI: 10.5958/0974-360X.2020.00856.2   

Address: T. Prannoy, P. K. Lakshmi
Department of Pharmaceutics, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
In-situ gel formulations were prepared by using different concentrations of sodium alginate, calcium carbonate, trisodium citrate and release retardant polymers. pH triggered ionic gelation is the mechanism involved in the present study. Taguchi L9 OA experimental design was employed for the optimization of formulations. All the formulations were subjected to various evaluation parameters. Taguchi formulations F2 and F6 were found to release the drug for up to 7 hrs hence these formulations were optimized. The formulations were found to follow First order drug release kinetics, the drug release mechanism for both formulations were found to be follow Korsemayer peppas drug release mechanism. From the values of release component “n” it can be concluded that both formulations have fickian diffusional release mechanism. Gastroretentive X-ray imaging study on Albino rabbit demonstrated that it was able to float in the stomach for more than 4hrs. The hydrodynamically balanced oral in-situ gel of lamotrigine could be an effective dosage form which remains buoyant and overcome the cyclical effects of the conventional tablets and sustain the drug release for up to 7 hrs.


Cite this article:
T. Prannoy, P. K. Lakshmi. Design and Optimization of Hydrodynamically balanced oral In-situ gel of Lamotrigine. Research J. Pharm. and Tech. 2020; 13(10):4865-4870. doi: 10.5958/0974-360X.2020.00856.2


REFERENCES:
1.    Subhash Debnath, Niranjan Babu M, Kusuma G, Saraswathi K, Sramika N R, Ankith K Reddy. Formulation and evaluation of floatable in situ gel as carrier for stomach-specific drug delivery of metoclopramide HCl. IJPFR. 2011; 1(1):53-64.
2.    Vora Vipul, Biswajit Basu. Formulation and characterization of novel floating in situ gelling system for controlled delivery of ramipril. International Journal of Drug Delivery. 2013; 5:43-55.
3.    Lakshmi PK, Swetha Reddy, Kishore C and Satish Reddy B. Formulation and Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions. Iranian Journal of Pharmaceutical Sciences.2013; 9 (1) 1-12.
4.    Swathi G., Lakshmi PK. Design and Optimization of Hydrodynamically Balanced Oral in Situ Gel of Glipizide. J App Pharm Sci, 2015; 5 (1): 031-038.
5.    Jadhav S L, Benerjee S K. Formulation and evaluation of floating in situ gel of nizatidine. International Journal of Research in Pharmaceutical Sciences. 2013; 4(2): 250-25.
6.    Panwar P, Chourasiya D and Jain G. Formulation and evaluation of oral floatable in-situ gel of diltiazem HCL. International Journal of Novel Drug Delivery Technology. 2012; 2: 264-270.
7.    Kubo W, Miyazaki S and Attwood D. Oral sustained delivery of paracetamol from in situ gelling gellan and sodium alginate formulations. Int J Pharm. 2003; 258: 55-64.
8.    Rishad Jivani R, Chhagan Patel N, Dashrath Patel M and Nurudin Jivani P. Development of a novel floating in-situ gelling system for stomach specific drug delivery of the narrow absorption window drug baclofen. Iranian Journal of Pharmaceutical Research, 2010; 9(4):359-368.
9.    Ganapati R, Bhimagoni K and Sridhar AS. Floating Drug delivery of a locally acting H2 antagonist: An approach using an in-situ gelling liquid formulation. Acta Pharmaceutica. 2009; 59, pp.345– 354.
10.    Shivaraju, Parthiban S, Senthilkumar S K. Preparation and evaluation of ornidazole in situ gelling system for gastroretentive drug delivery. International Journal of Pharmacy. 2013; 3(2):62-69.
11.    Basavaraj Nanjwade K, Sagar Adichwal A, Veerendra Nanjwade K, Kishori Gaikwad R, Sachin Thakare A and Manvi F V. Development and evaluation of gastroretentive floating tablets of glipizide based on effervescent technology. Journal of Drug Metabolism and Toxicology. 2012; 3(3): 1-6.

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