Author(s): Murugan S, Vetrichelvan T

Email(s): msm_apcp07@yahoo.com

DOI: 10.5958/0974-360X.2020.00851.3   

Address: Murugan S1,2*, Vetrichelvan T1
1Department of Pharmaceutical Analysis, Adhiparasakthi College of Pharmacy, Melmaruvathur-603319, Tamilnadu, India.
2Research Scholar, The Tamilnadu Dr. M.G.R. Medical University, Chennai-600032, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
Two simple UV method was developed for the determination of sonidegib in bulk and pharmaceutical dosage form. The method involves the Zero and First order derivative. Sonidegib has ?max 277nm in zero order. In first order the wavelength selected was 293nm. The methods were found to be linear between the range of 3–15µg/ml for Sonidegib in methanol. The Zero and First-order derivative methods shows good linearity in the above concentration range and correlation coefficient is 0.9994 and 0.9998, respectively.


Cite this article:
Murugan S, Vetrichelvan T. Development and Validation of UV Spectroscopic method for the determination of Sonidegib in Bulk and Pharmaceutical dosage form. Research J. Pharm. and Tech. 2020; 13(10):4836-4838. doi: 10.5958/0974-360X.2020.00851.3

Cite(Electronic):
Murugan S, Vetrichelvan T. Development and Validation of UV Spectroscopic method for the determination of Sonidegib in Bulk and Pharmaceutical dosage form. Research J. Pharm. and Tech. 2020; 13(10):4836-4838. doi: 10.5958/0974-360X.2020.00851.3   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-10-54


REFERENCE:
1.    https://www.drugbank.ca/drugs/DB09143
2.    https://en.wikipedia.org/wiki/Sonidegib
3.    https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:90863
4.    Code Q2A – Text on Validation of Analytical Procedure Methodology Step-3 Consensus Guideline, ICH Harmonised Tripartite Guideline, 2005.
5.    Code Q2B – Text on Validation of Analytical Procedure Methodology Step-3 Consensus Guideline, ICH Harmonised Tripartite Guideline, 1994.

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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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