Author(s):
Bambang Wijianto, Ritmaleni, Hari Purnomo, Arief Nurrochmad
Email(s):
ritmaleni@ugm.ac.id
DOI:
10.5958/0974-360X.2020.00850.1 
Address:
Bambang Wijianto1,3, Ritmaleni1*, Hari Purnomo1, Arief Nurrochmad2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
2Department of Pharmacology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia.
3Department of Pharmaceutical Chemistry, Faculty of Medicine, Universitas Tanjungpura, Pontianak, Indonesia.
*Corresponding Author
Published In:
Volume - 13,
Issue - 10,
Year - 2020
ABSTRACT:
The objective of this study was to design new mono-ketone analogs of curcumin and determine its lipid peroxidation inhibition. Molecular modeling studies were carried out by using the semi-empirical quantum chemical algorithm AM-1 method in MOE 2018.01.01 software. Build QSAR was used to generate an equation model that will be used to design new mono-ketone analogs of curcumin. Synthesis of new compounds produced from an aldol condensation reaction. Thiobarbituric acid reactive substance (TBARS) method was used to determine antioxidant activity by measuring lipid peroxide concentration. Promising predictions values of lipid peroxidation the QSAR study obtained inhibitory activity. The in vitro lipid peroxidation inhibition of 2,6-bis-(3'-ethoxy, 4'-hydroxybenzylidene)-cyclohexanone; 2,6-bis-(3'-Bromo,4'-methoxybenzylidene)-cyclohexanone; and 2,6-bis-(3',4'-dimethoxybenzylidene)-cyclohexanone indicates good inhibitory with IC50 values of 2.95; 0.95; and 2.45µM respectively. The new mono-ketone analogs of curcumin compound from the QSAR study has been shown to have antioxidant activity by inhibiting lipid peroxidation by scavenging free radicals.
Cite this article:
Bambang Wijianto, Ritmaleni, Hari Purnomo, Arief Nurrochmad. Quantitative Structure Activity Relationship (QSAR) study and Biological evaluation on Mono-ketone analogs of Curcumin as Antioxidant. Research J. Pharm. and Tech. 2020; 13(10):4829-4835. doi: 10.5958/0974-360X.2020.00850.1
Cite(Electronic):
Bambang Wijianto, Ritmaleni, Hari Purnomo, Arief Nurrochmad. Quantitative Structure Activity Relationship (QSAR) study and Biological evaluation on Mono-ketone analogs of Curcumin as Antioxidant. Research J. Pharm. and Tech. 2020; 13(10):4829-4835. doi: 10.5958/0974-360X.2020.00850.1 Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-10-53
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