Author(s): Dhanaja Kotte, Kumaraswamy Gullapelli, Brahmeshwari Gavaji, Ramchander Merugu, Ravichander Maroju, Muralikrishna Patwari


DOI: 10.5958/0974-360X.2020.00836.7   

Address: Dhanaja Kotte1, Kumaraswamy Gullapelli2*, Brahmeshwari Gavaji1, Ramchander Merugu3, Ravichander Maroju2, Muralikrishna Patwari4
1Department of Chemistry, Kakatiya University, Warangal, India - 506009.
2Department of Chemistry, Mahatma Gandhi Institute of Technology, Hyderabad, India - 500075.
3Department of Biochemistry, Mahatma Gandhi University, Nalgonda, India, 508254.
4Department of Chemistry, Chaitanya Bharathi Institute of Technology, Hyderabad, India, 500075.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020

A series of new triazinane-2-thiones and imino thiazolidinone-4-ones were synthesized from 2-acetyl benzimidazole (1). Treatment of compound 1 with urea in the presence of I2 furnishes compound (2), which on reaction with Aryl isothiocyanateaffords the compound (3), which undergoes Cyclic condensation of classical Mannich amino methylation of compound 3with formaldehyde and methyl amine produces corresponding triazinane -2-thiones (4), whereas cyclic condensation of compound 3 with cholroacetic acid to furnish the corresponding iminothiazolidinones-4-ones(5).the chemical structures of the newly synthesized compounds have been characterized on the basis of spectral (IR,1HNMR and Mass) and analytical data. The title compounds were evaluated for their anti-inflammatory activity and molecular docking studies. The docking studies are supporting anti-inflammatory activity exhibiting high inhibition constant and binding energy.

Cite this article:
Dhanaja Kotte, Kumaraswamy Gullapelli, Brahmeshwari Gavaji, Ramchander Merugu, Ravichander Maroju, Muralikrishna Patwari. An Efficient Synthesis, Anti inflammatory activity and Molecular Docking Studies of new Triazinanes and Iminothiazolidinones. Research J. Pharm. and Tech. 2020; 13(10):4743-4750. doi: 10.5958/0974-360X.2020.00836.7

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