Author(s): Alfred Maroyi


DOI: 10.5958/0974-360X.2020.00830.6   

Address: Alfred Maroyi
Department of Biodiversity, University of Limpopo, Private Bag X1106, Sovenga 0727, South Africa.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020

Vernoniastrum ambiguum is a herbaceous plant used as traditional medicine in tropical Africa. This study was aimed at providing a critical review of the pharmacological properties, phytochemistry and medicinal uses of V. ambiguum. Documented information on the pharmacological properties, phytochemistry and medicinal uses of V. ambiguum was collected from several online sources such as Scopus, Google Scholar, PubMed and Science Direct, and pre-electronic sources such as book chapters, books, journal articles and scientific publications obtained from the University library. This study showed that the leaves, roots and whole plant parts of V. ambiguum are used as traditional medicines for dysmenorrhoea, gonorrhoea, impotence, postpartum pains, colds, female and male infertility, malaria, fever and cough. Phytochemical compounds identified from the species include glaucolide sesquiterpenes, alkaloids, amino acids, anthraquinones, cardiac glycosides, flavonoids, phenols, saponins, steroids, tannins and triterpenes. Pharmacological research revealed that V. ambiguum extracts and compounds isolated from the species have antibacterial, antifungal, anti-quorum sensing inhibition, antioxidant, antiplasmodial and hepatoprotective activities. Vernoniastrum ambiguum should be subjected to detailed phytochemical, pharmacological and toxicological evaluations aimed at correlating its medicinal uses with its phytochemistry and pharmacological properties.

Cite this article:
Alfred Maroyi. Evaluation of Pharmacological properties, Phytochemistry and Medicinal uses of Vernoniastrum ambiguum. Research J. Pharm. and Tech. 2020; 13(10):4715-4719. doi: 10.5958/0974-360X.2020.00830.6

1.    Isawumi MA. Infrageneric classification of Vernonia (Vernonieae: Compositae) in West Africa. In Hind DJN, Beentje HJ (Editor), Compositae: systematics. Proceedings of the International Compositae Conference. Royal Botanic Gardens, Kew, London, UK. 1996; pp. 531-544.
2.    Robinson H, Skvarla JJ, Funk VA. Vernonieae (Asteraceae) of southern Africa: A generic disposition of the species and a study of their pollen. PhytoKeys. 2016; 60: 49–126.
3.    Robinson H. Generic and subtribal classification of American Vernonieae. Smithsonian Contributions to Botany. 1999; 89: 1–116.
4.    Robinson H. The status of generic and subtribal revisions in the Vernonieae. In Hind DJN, Beentje HJ (Editor), Compositae: systematics. Proceedings of the International Compositae Conference. Royal Botanic Gardens, Kew, London, UK. 1996; pp. 511-529.
5.    Robinson H. Tribe Vernonieae Cass. In Kadereit JW, Jeffrey C (Editor), The families and genera of vascular plants: Flowering plants: Eudicots, Asterales. Springer, Berlin, Germany. 2007; pp. 149-174.
6.    Isawumi MA. The status of generic revision in the African Vernonieae (Asteraceae). Compositae Newsletter. 2008; 46: 27-48.
7.    Beentje HJ, Jeffrey C, Hind DJN. Compositae: Part 3. Flora of tropical East Africa. Kew, Royal Botanic Gardens, London, UK. 2005.
8.    Makokha DW, Irakiza R, Malombe I, Le Bourgeois T, Rodenburg J. Dualistic roles and management of non-cultivated plants in lowland rice systems of East Africa. South African Journal of Botany. 2017; 108: 321–330.
9.    Chinwe UA. Anatomical studies of the midrib, petiole and epidermal strip of some Vernonia species, from Nigeria. International Journal of Botany 2020. 16: 9-19.
10.    Achigan–Dako EG, Ndanikou S. Diversity of traditional vegetables and local taxonomy. In Achigan–Dako EG, Pasquini MW, Assogba Komlan F, Ndanikou S, Dansi A, Ambrose–Oji B. Traditional vegetables in Benin: Diversity, distribution, ecology, agronomy and utilization. Institut National des Recherches Agricoles du Bénin. Imprimeries du CENAP, Cotonou, Benin. 2010; pp. 20-47.
11.    Lucha CF, Chuyong GB. Ethnobotanical survey of fodder/forage plant species in range and farming systems in the savannahs of Ngoketunjia, north western Cameroon. International Journal of Current Research in Biosciences and Plant Biology. 2016; 3(6): 50-72.
12.    Akunne CE, Akpan AU, Ononye BU. Pattern of nectariferous plant diversity of African honeybee (Apis mellifera adansonii L.) in Awka and Agulu environs, southeast Nigeria. Journal of Apiculture 2016; 31(4): 281-291.
13.    Aworinde DO, Ogundairo BO, Erinoso SM. Comparative leaf architectural studies of some Vernonia Schreb (Asteraceae) in Nigeria. Current Botany. 2013; 4(3): 43-47.
14.    Focho DA, Nkeng EAP, Lucha CF, Ndam WT, Afegenui A. Ethnobotanical survey of plants used to treat diseases of the reproductive system and preliminary phytochemical screening of some species of Malvaceae in Ndop central sub-division, Cameroon. Journal of Medicinal Plants Research. 2009; 3: 301–314.
15.    Toyang NJ, Verpoorte R. A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). Journal of Ethnopharmacology. 2013; 146: 681–723.
16.    Builders MINN, Ajoku GA, Builders PF, Orisadipe A, Aguiyi JC. Evaluation of the antimalarial potential of Vernonia ambigua Kotschy and Peyr (Asteraceae). International Journal of Pharmacology. 2011; 7: 238–247.
17.    Tsobou R, Mapongmetsem PM, Van Damme P. Medicinal plants used for treating reproductive health care problems in Cameroon, central Africa. Economic Botany. 2016; 70(2): 145–159.
18.    Noumi E, Fozi FL. Ethnomedical botany of epilepsy treatment in Fongo-Tongo village, western province, Cameroon. Pharmaceutical Biology. 2003; 41(5): 330-339.
19.    Colditz GA. The SAGE encyclopedia of cancer and society. SAGE Publications, California, USA; 2015.
20.    Burkill HM. The useful plants of west tropical Africa. Royal Botanic Gardens Kew, London, UK; 1985.
21.    Sobrinho ACN, de Souza EB, Fontenelle ROS. A review on antimicrobial potential of species of the genus Vernonia (Asteraceae). Journal of Medicinal Plants Research. 2015; 9(31): 838-850.
22.    Builders MI. In search of a potent antimalarial agent: Antiplasmodial assessment of three herbs with folkloric antimalarial claims. International Journal of Biomedical and Clinical Sciences. 2018; 3(3): 40-46.
23.    Kunle OF, Egharevba HO. Preliminary studies on Vernonia ambigua: Phytochemical and antimicrobial screening of the whole plant. Ethnobotanical Leaflets. 2009; 13: 1216–1221.
24.    Aliyu B. Phytochemistry and quorum sensing inhibitory studies of four Vernonia species growing in Nigeria. PhD Thesis, University of KwaZulu-Natal, Durban, South Africa; 2017.
25.    Okafo SE, Anie CO, Nwanua MC. Formulation and evaluation of antimicrobial topical creams from ethanol extract of Vernonia ambigua leaves. Nigeria Journal of Pharmaceutical Research. 2019, 15 (2) pp 249 – 255.
26.    Kunle OF, Egharevba HO, Ibrahim J, Iliya I, Abdullahi MS, Okwute SK, Okogun JI. Antimicrobial activity of the extract of Vernonia ambigua (aerial part). Researcher. 2010; 2(6): 74-80.
27.    Aliyu AB, Musa AM, Abdullahi MS, Ibrahim H, Oyewale OA. Phytochemical screening and antibacterial activities of Vernonia ambigua, Vernonia blumeoides, Vernonia oocephala (Asteraceae). Acta Poloniae Pharmaceutica Drug Research. 2011; 68: 67–73.
28.    Ilondu EM. Fungitoxic activity of leaf extracts from four Asteraceae against Sclerotium rolfsil Sacc., an isolate of sweet potato (Ipomoea batatas (L) Lam) vine rot disease. Journal of Agricultural and Biological Sciences. 2012; 3(2): 287-295.
29.    Ilondu EM. Phytochemical composition and efficacy of ethanolic leaf extracts of some Vernonia species against two phytopathogenic fungi. Journal of Biopesticides. 2013; 6(2): 165-172.
30.    Omoigui ID, Aromose OSA. Nature of ergastic substances in some Nigerian Asteraceae. Bayero Journal of Pure and Applied Sciences. 2012; 5(2): 160–167.
31.    Bhowmik D, Pankaj C, Tripathi KK, Chandira MR, Kumar KPS. Zingiber officinale the herbal and traditional medicine and its therapeutically importance. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(2): 102-110.
32.    Singh UP, Parthasarathy R. Comparative pharmacognostical, preliminary phytochemical and acute toxicological evaluation of Blumea lacera var lacera and Blumea eriantha DC. Research Journal of Pharmacy and Technology. 2012; 5(6): 834-841.
33.    Sahu L, Roy A, Satapathy T. A phytopharmacological review on Lawsonia inermis L. Research Journal of Science and Technology. 2012; 4(3): 93-107.
34.    Mukhtar HM, Singh M, Vashishth D, Singh S, Kaur H. Standardization of the dried aerial parts of Bidens pilosa. Research Journal of Pharmacognosy and Phytochemistry. 2013; 5(2): 84-86.
35.    Mital NM, Desai TR. In vitro anti-inflammatory and anti-Arthritic activities of fruits of Vernonia anthelmintica Willd. (Asteraceae). Asian Journal of Pharmaceutical Research. 4(4): 186-188.
36.    Bhatt DY, Pandya SS. Pharmacognostic and preliminary phytochemical studies on the leaf of Beta vulgaris Linn. (Chenopodiaceae). Research Journal of Pharmacognosy and Phytochemistry. 2015; 7(3): 163-166.
37.    Tiwari VJ. Validity of ethnopharmacological uses of Vicoa indica (L.) DC., family – Asteraceae. Research Journal of Pharmacognosy and Phytochemistry. 2018; 10(3): 207-210.
38.    Gopalasatheeskumar K, Ariharasiva KG, Sengottuvel T, Sanish DV, Srividhya V. Quantification of total phenolic and flavonoid content in leaves of Cucumis melo var agrestis using UV- spectrophotometer. Asian Journal of Research Chemistry. 2019; 12(6): 335-337.
39.    Taheri F, Abbaszadeh S, Valibeik A, Sattari E, Gholami E. The most important natural antioxidants and native herbs of Iran used in the nervous system as pre-anesthetics. Research Journal of Pharmacy and Technology. 2019; 12(3): 1453-1456.
40.    Rohini KC, Rajesh CY. A review on phytopharmacological profile of traditionally used medicinal plant Parkia biglandulosa (Mimosaceae). Asian Journal of Pharmaceutical Research. 2020; 10(1): 34-38.
41.    Aliyu AB, Oshanimi JA, Sulaiman MM, Gwarzo US, Garba ZN, Oyewale AO. Heavy metals and mineral elements of Vernonia ambigua, Vernonia oocephala and Vernonia pupurea used in northern Nigerian traditional medicine. Vitae. 2015; 22(1): 27-32.
42.    Akinwande AA, Ogunshakin RY, Krishnamurthy R. Non specific immune response in the African catfish, Heterobranchus longifilis fed diets fortified with ethanolic extracts of selected traditional medicinal plants and disease resistance against Pseudomonas aeruginosa. Journal of Agricultural Research and Development. 2016; 15(1): 9-23.
43.    Orji OU, Ibiam UA, Aja PM, Uraku AJ, Inya-Agha OR, Ugwu OPC. Hepatoprotective activity of ethanol extract of Vernonia ambigua against carbon tetrachloride induced hepatotoxicity in albino rats. IOSR Journal of Dental and Medical Sciences. 2015; 14(9): 22-29.

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