Author(s): P. Shanmugapriya, K. Manivel, R. Selvamuthukumar, R. Sanilkumar

Email(s): shanmugapriyapugazh2301@gmail.com

DOI: 10.5958/0974-360X.2020.00826.4   

Address: Ms. P. Shanmugapriya1*, Mr. K. Manivel2, Mr. R. Selvamuthukumar1, Dr. R. Sanilkumar1
1Department of Pharmacy, Annamalai University, Chidambaram, Annamalainagar - 608002, Tamilnadu, India.
2Research Associate, R&D Apex Laboratories, Chennai- 603105.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
Potassium chloride tablets help to treat hypokalemia.it is an extended-release tablet, Ethocel 100FP and hydrogenated vegetable oil helps for controlled release. Extended-release reduces gastric irritation.it is soluble in glycerol, so we use isopropyl alcohol as a solvent, direct compression we don’t need any solvent for wet granulation, so we add isopropyl alcohol. For blend parameter’s we use Hausner's ratio from the seven which one is lowest it should be the good one, healthy dose of potassium for an adult is 50 to 100mEq per day. the assay performed by the method of HPLC (anhydrous basis), totally seven formulations was done by direct compression. Wet granulation method, F1 and F2 formulated by direct compression method, F3 formulated by non-aqueous method, F4 to F7 was formulated by wet granulation finally carry out stability study to known the stable formulation. One stability study maintain these following temperature and humidity 40?C?2?C 75% RH ? 5% it is followed by as per the ICH guidelines no changes added in these process, we perform stability test for every month and the data should contain assay, dissolution at 2hrs, and Karl fisher range to known water content. dissolution profile state that drug release with the specific time intervals the value should be close to the reference product (Mfg by Upsher-Smith laboratories inc).


Cite this article:
P. Shanmugapriya, K. Manivel, R. Selvamuthukumar, R. Sanilkumar. Formulation Development and In-vitro Evaluation of Potassium Chloride Extended-Release tablets. Research J. Pharm. and Tech. 2020; 13(10):4697-4701. doi: 10.5958/0974-360X.2020.00826.4


REFERENCES:
1.    Bandelin FJ. Compressed tablets by wet granulation. Pharmaceutical dosage forms: tablets. 1989;1: 131-93.
2.    Turkoglu M, Sakr A. Tablet dosage forms. Modern pharmaceutics. 2016:481-98.
3.    Heimlich J, Ganorkar L, Lee E, Noack R, VerHage R. Zero-order sustained release dosage forms and method of making same. Google Patents; 2003.
4.    Shinde N, Aloorkar N, Kulkarni A, Bangar B, Sulake S, Kumbhar P. Recent Advances in Granulation Techniques. Asian J Res Pharm Sci. 2014;4 (1):38-47.
5.    Cartwright A, Shah C. An in vitro dissolution test for slow release potassium chloride tablets. Journal of Pharmacy and Pharmacology. 1977;29 (1):367-9.
6.    Flores HE, Galston AW. Analysis of polyamines in higher plants by high performance liquid chromatography. Plant physiology. 1982;69 (3):701-6.
7.    Pharmacopoeia B. British pharmacopoeia. 2016.
8.    Banakar UV. Pharmaceutical dissolution testing: CRC Press; 1991.
9.    Şenel S, Capan Y, Hncal A. Factors affecting the formulation of sustained release potassium chloride tablets. Pharmaceutical Technology: Controlled Drug Release Vol 2: CRC Press; 1991. p. 33-42.
10.    Kumar CP, Rao KM, Saravanan D, Padmavathy J, Kumar CP, Lakshmi IA. Formulation and evaluation of potassium chloride extended release capsules. J Pharm Res. 2011; 4:2529-32.

Recomonded Articles:

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

Author(s): Suman Katteboina and VSR Chandrasekhar P

DOI: Not Available         Access: Open Access Read More

Author(s): P. Shanmugapriya, K. Manivel, R. Selvamuthukumar, R. Sanilkumar

DOI: 10.5958/0974-360X.2020.00826.4         Access: Closed Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags