Author(s): Enas Abdul Kareem Jabbar, Afrah Abid Maktoof, Jamela Jouda

Email(s): dr.enaskareem_bio@sci.utq.edu.iq , Afrah.m_bio@sci.utq.edu.iq , jamela.jouda@uomustansiriyah.edu.iq

DOI: 10.5958/0974-360X.2020.00819.7   

Address: Enas Abdul Kareem Jabbar1*, Afrah Abid Maktoof2, Jamela Jouda3
1Department of Medical Basic Science, College of Nursing, University of Thi-Qar.
2Department of Biology, College of Science, University of Thi-Qar.
3Department of Biology, College of Science, Mustansiriyah University.
*Corresponding Author

Published In:   Volume - 13,      Issue - 10,     Year - 2020


ABSTRACT:
There is not enough literature on trace elements in sickle cell anemia (SCA) in Iraq. Our investigation also revealed that studies scrutinizing iron deficiency anemia (IDA) are also rare all around the world. The aim of this research was to determine metal concentrations and physiological parameters in SCA patients and compare them with IDA patients. In this study, 31 SCA patients, 30 IDA patients, and 28 healthy people (male and female) were recruited from the Center of Genetic Diseases, Thi-Qar, Iraq (age range: 2-45 years). The blood types of all participants were recorded from their profiles. 5ml blood was collected from both patient and healthy groups to determine reticulum cells by slide method; other hematology tests were performed by hematology analyzer. The rest was centrifuged to obtain the serum used to determine ferritin level by minividas, vitamin D by cobas, and metals including copper, zinc, magnesium, and selenium by flame atomic absorption spectrophotometer. The age of IDA group was significantly higher than that of SCA group, while no significant difference was found in the gender of the two groups. In both groups, the highest frequency was found in the O blood type and the lowest in the B blood type. The results of estimated parameters showed that both anemia patients have significantly lower RBC count, Hb level, vitamin D level, and PCV% than those in control. However, ferritin level, reticular cells %, and WBC count were significantly higher in the SCA, and significantly lower in IDA, compared to the control. Copper and selenium levels were significantly higher, while zinc and magnesium levels were significantly lower in both patient groups compared to control. Accordingly, regular laboratory examination of these elements is inevitable.


Cite this article:
Enas Abdul Kareem Jabbar, Afrah Abid Maktoof, Jamela Jouda. Evaluation of Metal levels and Physiological parameters in Sickle cell anemia and their comparison with Iron deficiency anemia. Research J. Pharm. and Tech. 2020; 13(10):4655-4660. doi: 10.5958/0974-360X.2020.00819.7


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