Author(s): Mukthinuthalapati Mathrusri Annapurna, Raghu Raj Naik, Sistla Mounica Pratyusha

Email(s): mannapurna.mukthinuthalapati@gitam.edu

DOI: 10.5958/0974-360X.2020.00083.9   

Address: Mukthinuthalapati Mathrusri Annapurna*, Raghu Raj Naik, Sistla Mounica Pratyusha
Department of Pharmaceutical Analysis, GITAM Institute of Pharmacy,
GITAM (Deemed to be) University, Visakhapatnam-530045, India
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
Two new simple, precise and accurate spectrophotometric methods were developed for the simultaneous determination of Glibenclamide and Metformin combined dosage forms. First order derivative (Method I) and simultaneous equation method (Method II) were developed for the assay of Glibenclamide and Metformin in phosphate buffer (pH 8.0). Linearity was observed 1-80 µg/ml and 1-10 µg/ml in Method I for Glibenclamide and Metformin respectively; 10-100 µg/ml and 1-10 µg/ml in Method II for Glibenclamide and Metformin respectively. Both the methods were validated and applied for the simultaneous determination of Glibenclamide and Metformin tablets.


Cite this article:
Mukthinuthalapati Mathrusri Annapurna, Raghu Raj Naik, Sistla Mounica Pratyusha. Development and validation of simultaneous spectrophotometric determination of Glibenclamide and Metformin tablets. Research J. Pharm. and Tech. 2020; 13(1): 425-428. doi: 10.5958/0974-360X.2020.00083.9

Cite(Electronic):
Mukthinuthalapati Mathrusri Annapurna, Raghu Raj Naik, Sistla Mounica Pratyusha. Development and validation of simultaneous spectrophotometric determination of Glibenclamide and Metformin tablets. Research J. Pharm. and Tech. 2020; 13(1): 425-428. doi: 10.5958/0974-360X.2020.00083.9   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-1-83


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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