Author(s): Dhruv Patel, Upendra Patel, Maitri Shukla, Bhavin Bhimani, Ghanshyam Patel

Email(s): maitrishukla1234@gmail.com

DOI: 10.5958/0974-360X.2020.00082.7   

Address: Mr. Dhruv Patel*, Dr. Upendra Patel, Maitri Shukla, Mr. Bhavin Bhimani, Mr. Ghanshyam Patel
Arihant School of Pharmacy and Bioresearch Institute, Adalaj, Gandhinagar-382421
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
Simvastatin is an Antilipidemic agent. The aim is to formulate and evaluate immediate release Simvastatin tablets prepared by wet granulation method. Sodium starch glycolate and crosscarmellose sodium were used as superdisintegrants. Formulations were prepared by Simvastatin with different concentration (1%, 2% and 3%) of crosscarmellose sodium and sodium starch glycolate. Formulations were evaluated for different pre and post compression parameter and in vitro drug release studies. The FTIR studies showed that there is no interaction between the drug and polymer. The results of pre compression parameters of batch I1 to I6 were compared with prescribed limits. It showed that batch I1 to I6 powder blend exhibit good flow property and compressibility property. In formulation I1-I6, disintegration time was observed 3-8 min and 100% drug released within 10-60 min time interval. Thus, based on evaluation of different parameters it was concluded that formulation of immediate release tablets of Simvastatin was successfully done and I2 showed almost 100% drug release at 10 min.


Cite this article:
Dhruv Patel, Upendra Patel, Maitri Shukla, Bhavin Bhimani, Ghanshyam Patel. Formulation and Evaluation of Immediate Release Tablet of Simvastatin. Research J. Pharm. and Tech. 2020; 13(1):421-224. doi: 10.5958/0974-360X.2020.00082.7

Cite(Electronic):
Dhruv Patel, Upendra Patel, Maitri Shukla, Bhavin Bhimani, Ghanshyam Patel. Formulation and Evaluation of Immediate Release Tablet of Simvastatin. Research J. Pharm. and Tech. 2020; 13(1):421-224. doi: 10.5958/0974-360X.2020.00082.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-1-82


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DOI: 10.5958/0974-360X 

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