Author(s): Gaurav Kumar Pathak, Himansu Chopra, Gyanendra Kumar Sharma

Email(s): gkpathak92@gmail.com

DOI: 10.5958/0974-360X.2020.00076.1   

Address: Gaurav Kumar Pathak*, Himansu Chopra, Gyanendra Kumar Sharma
Rajiv Academy for Pharmacy, Mathura, 281001
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
the objective of present study was to develop bio adhesive floating micro sponges of domperidone. (DOM) so as to accomplish an all-inclusive maintenance in the upper GIT, which may bring about upgraded assimilation and accordingly improved bioavailability. Floating drug delivery system have a mass thickness not exactly gastric liquids and so remains buoyant in stomach without influencing gastric purging rate for a drawn out timeframe. DOM and multiparticulate medicate conveyance framework make DOM a very good candidate for formulation of floating drug delivery system. Floating microsponges of DOM were set up by quassi emulsion technique. Domperdome floating microsponges are set up to improve site specific absorption of drug for emetic treatment. Modified quasi emulsion solvent diffusion technique was used to utilized microsponges. Various concentrations of Acconon MC 8-2 EP/NF and Polyvinyl alcohol were used and the prepared microsponges were evaluated for % entrapment efficiency, % buoyancy and % cumulative drug release. It was found that the % entrapment efficiency was 82.24%, % buoyancy was 82.3% and % cumulative drug release was 88.7% for F6 formulation. This investigation introduces another methodology dependent on floating ability of microsponges for treatment of emetic. Rapid gastrointestinal transit can prevent complete drug release in the absorption zone and reduce the efficacy of administered dose since the majority of drugs are absorbed in the stomach or the upper part of small intestine.


Cite this article:
Gaurav Kumar Pathak, Himansu Chopra, Gyanendra Kumar Sharma. Formulation, development and evaluation of bioadhesive floating Microsponges of Domperidone. Research J. Pharm. and Tech. 2020; 13(1): 383-390. doi: 10.5958/0974-360X.2020.00076.1


Recomonded Articles:

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

Author(s): Rakhi Mehra, Renu Makhija, Neera Vyas

DOI: Not Available         Access: Open Access Read More

Author(s): Jino Elsa Thomas, Usha Y Nayak*, Jagadish PC, Koteshwara KB

DOI: 10.5958/0974-360X.2017.00007.5         Access: Open Access Read More

Author(s): Abhirup Dey, Mangala Lakshmi Ragavan, Sanjeeb Kumar Mandal, Nilanjana Das

DOI: 10.5958/0974-360X.2017.00136.6         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

Author(s): Mistry Khushboo, Kavya Naik, Vasanthi, Alicia Menezes, Anup Naha, K.B. Koteshwara, K. Girish Pai

DOI: 10.5958/0974-360X.2017.00540.6         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): M. Sumithra, Avantika Prabhabanik

DOI: 10.5958/0974-360X.2017.00036.1         Access: Open Access Read More

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags