Author(s): Ekta Khare, Pradeep Kashyap, Unnati Kushwaha

Email(s): ektakhare23@gmail.com

DOI: 10.5958/0974-360X.2020.00020.7   

Address: Ekta Khare1*, Pradeep Kashyap1, Unnati Kushwaha2
1School of Pharmacy, I.T.M. University, Gwalior (Madhya Pradesh), 474001, India.
2Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow (Uttar Pradesh), 226031, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2020


ABSTRACT:
Ketones and alcohols are extremely important industrial and biological chemicals. The interconversion of alcohols and ketones or aldehydes occurs in a number of biochemical pathways. Diphenylmethanol bearing number of biological activity like antihypertensive and antiallergic agents as well as intermediate compound for further synthesis of drugs. For these reasons, they gained much attention as important pharmacophore and privileged structure in medicinal chemistry. The objective of this study was to determine efficiency or binding energy of Diphenyl methanol to identify antihypertensive activity. We have reduced alcohol into ketones and performed Molecular modeling. Scoring Function analysis has permitted identification and Characterization of ligand receptor interactions.


Cite this article:
Ekta Khare, Pradeep Kashyap, Unnati Kushwaha. Design, Molecular Modelling and Synthesis of Antihypertensive Agent. Research J. Pharm. and Tech. 2020; 13(1): 101-105. doi: 10.5958/0974-360X.2020.00020.7

Cite(Electronic):
Ekta Khare, Pradeep Kashyap, Unnati Kushwaha. Design, Molecular Modelling and Synthesis of Antihypertensive Agent. Research J. Pharm. and Tech. 2020; 13(1): 101-105. doi: 10.5958/0974-360X.2020.00020.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-1-20


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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