Author(s): Sri Datla V.V. S. S. N. Raju, A. Manikandan, S. Venkat Rao

Email(s): dvsraju70@gmail.com

DOI: 10.5958/0974-360X.2019.00739.X   

Address: Sri Datla V.V. S. S. N. Raju1, A. Manikandan1, S. Venkat Rao2
1Department of chemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai-600073, Tamilanadu, India
2SMS Pharmaceuticals Ltd, R & D centre (A DSIR approved), Gagillapur, Telangana-500047, India
*Corresponding Author

Published In:   Volume - 12,      Issue - 9,     Year - 2019


ABSTRACT:
A simple, Accurate, precise method was developed for the simultaneous estimation of the Glecaprevir and Pibrentasvir in tablet dosage form. Chromatogram was run through CHSC18 100 x 4.6 mm, 3m. Mobile phase containing Buffer 0.01N NaH2PO4.H2O (4.5pH): Acetonitrile taken in the ratio 50:50v/v was pumped through column at a flow rate of 0.3 ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was 260 nm. Retention time of Glecaprevir and Pibrentasvir were found to be 0.677 min and 0.965 min. %Recovery was obtained as 99.84% and 100.07% for Glecaprevir and Pibrentasvir individually. LOD, LOQ values obtained from regression equations of Glecaprevir and Pibrentasvir were 0.61, 1.86 and 0.27, 0.73 respectively. Regression equation of Glecaprevir is y = 3763.x + 3938, and y = 4975.x + 4107of Pibrentasvir.


Cite this article:
Sri Datla V.V. S. S. N. Raju, A. Manikandan, S. Venkat Rao. Validation of Simple Isocratic RP-UPLC Method for Glecaprevir and Pibrentasvir determination and its Application in the Study of Stress Degradation. Research J. Pharm. and Tech 2019; 12(9):4299-4304. doi: 10.5958/0974-360X.2019.00739.X


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


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