Author(s): Sergey Kotelevets, Sergey Chekh, Zukhra Karakotova

Email(s): smkotelevets@mail.ru

DOI: 10.5958/0974-360X.2019.00735.2   

Address: Sergey Kotelevets1*, Sergey Chekh2, Zukhra Karakotova3
1North Caucasus State Academy, Medical Institute, PhD in Medical Sciences, Professor, Cherkessk, Russian Federation.
2North Caucasus State Academy of Humanities and Technology, Head of Department of Software Development, Cherkessk, Russian Federation.
3North Caucasus State Academy of Humanities and Technology, Medical Institute, PhD Student, Cherkessk, Russian Federation.
*Corresponding Author

Published In:   Volume - 12,      Issue - 9,     Year - 2019


ABSTRACT:
The ethnic and the gender factors materially affect the prevalence of gastric atrophy.? All the patients were divided into five ethnic groups: Russians, Karachays, Abazins, Circassians, Nogais. The decrease in serum gastrin-17 less than 10 pmol/l is a sensitive and specific biomarker for antral mucosal atrophy, pepsinogen-I less than 25 µg/l is a corpus mucosal atrophy biomarker (Se - 89% and 92%, Sp - 97% and 96%). Gastrin-17 and pepsinogen-I are also sensitive and specific biomarkers for mild, moderate, severe atrophy of the antrum and corpus (for severe antral mucosal atrophy Se - 96%, Sp - 92%, for severe corpus mucosal atrophy Se - 88%, Sp - 97%). A total of 75 patients with multifocal atrophic gastritis were examined histologically. 67 patients had gastrin-17 <10 pmol/l and pepsinogen-I <25 µg/l at the same time. 7 patients had gastrin-17 from 10 to 11.5 pmol/l, 1 patient had gastrin-17 = 19 pmol/l (Se - 89%). Therefore, the level of gastrin-17 and pepsinogen-I simultaneously decreases among patients with multifocal atrophic gastritis. The prevalence of atrophic gastritis is significantly different among some ethnic populations living in the same territory under the same environmental and living conditions. These differences prove the presence of genetic polymorphism in different ethnic groups of the population.


Cite this article:
Sergey Kotelevets, Sergey Chekh, Zukhra Karakotova. Modern Possibilities of the Use of Non-Invasive Serological Biomarkers Severe in Population Studies. Research J. Pharm. and Tech 2019; 12(9):4274-4282. doi: 10.5958/0974-360X.2019.00735.2


Recomonded Articles:

Author(s): Karthikeson P.S , Gayathri.R, Vishnu Priya.V

DOI: 10.5958/0974-360X.2016.00289.4         Access: Open Access Read More

Author(s): Siripurapu Sriram, Venkata Ravibabu Mandla, Chaithanya Sudha M, Saladi S.V. Subba Rao, Nagaveni Ch, Vani V., Gobinath P., Raj Kumar KVG., Jaydeep Lella, Sannidhi Krishna Praveen, Debjit Datta

DOI: 10.5958/0974-360X.2017.00078.6         Access: Open Access Read More

Author(s): Sonte Sushmitha, Sedimbi Revathi Priyanka, L. Mohan Krishna, M. Srinavasa Murthy

DOI: Not Available         Access: Open Access Read More

Author(s): Anupama Deepak, Saravana Kumar

DOI: 10.5958/0974-360X.2016.00264.X         Access: Open Access Read More

Author(s): Mahadeva Rao US, San San Oo, Nurul Liana Sabrin, Norsyahira Syazwana Mohd Razali, Khairunnisa Khalid, Nurul Farihah Mohamed Nadzari, Thant Zin

DOI: 10.5958/0974-360X.2017.00065.8         Access: Open Access Read More

Author(s): Kiruthika Patturaja, Pradeep. D

DOI: 10.5958/0974-360X.2016.00258.4         Access: Open Access Read More

Author(s): Kalaiselvi. R, M.P. Brundha

DOI: 10.5958/0974-360X.2016.00398.X         Access: Open Access Read More

Author(s): Anuradha A. Ranpise, Shilpa P. Chaudhari, Atul A. Phatak, Pratiksha M. Kadam

DOI: Not Available         Access: Open Access Read More

Author(s): Deepak H B, Sabina Evan Prince

DOI: 10.5958/0974-360X.2017.00491.7         Access: Open Access Read More

Author(s): Sahil Choudhari, Vishnu Priya .V, R. Gayathri

DOI: 10.5958/0974-360X.2016.00362.0         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


Recent Articles




Tags