New substituted pyrazoles were prepared from Benzylidene acetophenone (chalcone) and hydrazine hydrate as starting materials through 2-chloro-1-(3, 5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-ethanone as intermediates. These intermediates on reaction with different amine (aliphatic and aromatic) in alcohol, finally converted into corresponding pyrazoles and were produced in excellent yields. The synthesized compounds were characterized by their physical properties (M.P and TLC) and UV, IR, 1HNMR, Mass spectroscopic studies respectively. The antimicrobial activity of synthesized pyrazoles was assessed by agar cup method. All the synthesized compounds were screened for the antimicrobial, Anthelmintic and haemostatic activity against some gram (+ve), Gran (-ve) organisms, Eudrilus eugenia and Human venous blood. The compounds exhibited moderate to good activity when compared with standard one.
Cite this article:
Faruk Alam. Synthesis and Biological Evaluation of Some Pyrazole-based Mannich Bases. Research J. Pharm. and Tech 2019; 12(9):4225-4230. doi: 10.5958/0974-360X.2019.00726.1