Author(s): Saadon Abdulla Aowda, Muhammad Hazim, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim, Phirdaous Abbas

Email(s): ahmedaldulaimi1@gmail.com , saripah@fsmt.upsi.edu.my

DOI: 10.5958/0974-360X.2019.00713.3   

Address: Yuhanis Mhd Bakri1, Ahmed Kareem Obaid Aldulaimi1*, Saripah Salbiah Syed Abdul Azziz1*, Mohd Azlan Nafiah1, Saadon Abdulla Aowda2, Muhammad Hazim1, Khalijah Awang3, Yumi Zuhanis Has-Yun Hashim4, Phirdaous Abbas5
1Department of Chemistry, Faculty of Science and Mathematics, Sultan Idris Education University, 35900 Tanjong Malim, Perak, Malaysia.
2Department of Chemistry, Faculty of Science, University Of Babylon, Babylon, Iraq
3Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
4International Institute for Halal Research and Training (INHART), International Islamic University Malaysia, P.O Box 10, 50728 Kuala Lumpur, Malaysia.
5Department of Biotechnology Engineering, Kul. of Engineering, International Islamic University Malaysia, P.O Box 10, 50728 Kuala Lumpur, Malaysia.
*Corresponding Author

Published In:   Volume - 12,      Issue - 9,     Year - 2019


ABSTRACT:
This study aimed to investigate the chemical constituents from Alphonsea cylindrica as well as their cytotoxic and xanthine oxidase inhibitory activities. The chemical compounds were isolated and purified by various chromatographic techniques and their structures were elucidated via modern spectroscopic techniques including NMR, MS, IR, UV and comparison with literature. A study on the barks of A. cylindrica has found eleven known compounds were identified as stigmasterol (1), isoursuline (2), cyathocaline (3), kinabaline (4), muniranine (5), isooncodine (6), iraqiine (7), O-methylmoschatoline (8), kareemine (9), atherospermidine (10) and N-methylouregidione (11). The cytotoxic effect of hexane, DCM and methanol of bark of A. cylindrica as well as the isolated compounds; 1, 2, 3, 4, 5, 7, 8, 9 and 10 were estimated on MCF-7 human breast cancer cells and isoursuline possessed the most potent inhibitory activity with IC50 value of 33 µg/ml. Eight compounds 1, 3, 4, 5, 6, 8, 10 and 11 displayed moderate inhibitory activity effect with IC50 < 100 µM against xanthine oxidase. As a conclusion, eleven compounds have been isolated from the bark of A. cylindrica King. Some of the compounds also showed potential against cytotoxicity and xanthine oxidase inhibitory activities. The findings of this study can enhance the understanding of the chemotaxonomy aspect of the A. cylindrica as well as its potential in traditional and modern medicine.


Cite this article:
Saadon Abdulla Aowda, Muhammad Hazim, Khalijah Awang, Yumi Zuhanis Has-Yun Hashim, Phirdaous Abbas. Cytotoxic and Xanthine Oxidase Inhibitory Activities of Chemical Constituents of Alphonsea cylindrica King. Research J. Pharm. and Tech 2019; 12(9):4129-4134.Research J. Pharm. and Tech 2019; 12(9):4129-4134. doi: 10.5958/0974-360X.2019.00713.3


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 


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