Author(s): Tristiana Erawati, Dewi Melani Hariyadi, Noorma Rosita, Tutiek Purwanti

Email(s): era_ffua@yahoo.co.id , tristiana-e-m@ff.unair.ac.id

DOI: 10.5958/0974-360X.2019.00617.6   

Address: Tristiana Erawati*, Dewi Melani Hariyadi, Noorma Rosita, Tutiek Purwanti
Department of Pharmaceutics Faculty of Pharmacy, Airlangga University, Surabaya, Indonesia
*Corresponding Author

Published In:   Volume - 12,      Issue - 8,     Year - 2019


ABSTRACT:
Objective: The nanostructured lipid carrier (NLC) system used the combination of beeswax-oleum cacao and virgin coconut oil (VCO) in this study, it was the development of nanoemulsion (NE) and solid lipid nanoparticle (SLN) delivery systems, which are used as nano-carriers of p-methoxycinnamic acid (PMCA). PMCA a secunder metabolite of champheria galanga has antiinflamatory effect which is difficult to dissolve in water. Several combinations of solid lipids (beeswax-oleum cacao) and liquid lipids (VCO) were prepared, namely F I (60:40); F II (70:30); and F III (80:20) in the NLC system. Material and Method: The NLC-PMCA system was prepared by the high shear homogenization method, then characterized and subjected to anti-inflammatory activity tests compared with nanoemulsion and solid lipid nanoparticle (SLN). The results of the research: The increasing concentration of VCO in the NLC-PMCA system resulted in lower viscosity, and greater entrapment efficiency, namely in the NLC-PMCA system with a combination of beeswax-oleum cacao and VCO of 60:40. NLC-PMCA with the combination of beeswax-oleum cacao and VCO of 60:40 (F I) has particle size (236.00 ± 17.15 nm) smaller than SLN-PMCA (665.60 ± 72.59 nm) but biger than NE-PMCA (29.27 ± 1.85 nm). Occlucivity of F I NLC-PMCA (41.50 ± 4.00 %) higher than SLN-PMCA (33.52 ± 3.65 %) and NE-PMCA (33.52 ± 3.65 %). PMCA in F I (60 : 40) NLC, SLN and NE has the equivalent anti-inflammatory activity based on the observations of the PMN cells number in ear skin mice with edema. Conclusion: The NLC-PMCA with the combination of beeswax-oleum cacao and VCO of 60:40 was the best formula.


Cite this article:
Tristiana Erawati, Dewi Melani Hariyadi, Noorma Rosita, Tutiek Purwanti. The Anti-inflammatory Activity of p-methoxycinnamic acid (PMCA) in the Nanostructured lipid carrier (NLC) system using combinations of solid lipid, beeswax-oleum cacao and liquid lipid, Virgin Coconut oil (VCO). Research J. Pharm. and Tech 2019; 12(8): 3619-3625. doi: 10.5958/0974-360X.2019.00617.6

Cite(Electronic):
Tristiana Erawati, Dewi Melani Hariyadi, Noorma Rosita, Tutiek Purwanti. The Anti-inflammatory Activity of p-methoxycinnamic acid (PMCA) in the Nanostructured lipid carrier (NLC) system using combinations of solid lipid, beeswax-oleum cacao and liquid lipid, Virgin Coconut oil (VCO). Research J. Pharm. and Tech 2019; 12(8): 3619-3625. doi: 10.5958/0974-360X.2019.00617.6   Available on: https://rjptonline.org/AbstractView.aspx?PID=2019-12-8-7


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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